Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression

Liu, Yun; Wang, Xue; Si, Bo; Wang, Tong; Wu, Yun; Liu, Ying; Zhou, Yemian; Tong, Haiyang; Zheng, Xinwei; Xu, An

doi:10.1016/j.envint.2022.107327

Cited by 7 publications

(2 citation statements)

References 65 publications

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“…However, Cd exposure in piglets induced the expression of multidrug resistance protein 1 (MRP1) ( Figure 3 G and Figure S2G,N,V ), a protein that generally excretes Cd out of the cell to exert the detoxification function [ 45 ]. Seemingly, the intrinsic capacity of cells to alleviate the Cd-induced cytotoxicity may not entirely rely on MT-mediated chelation, and the efflux proteins, such as MRP1, may have a more important role [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Integrating Transcriptomics and Proteomics to Characterize the Intestinal Responses to Cadmium Exposure Using a Piglet Model

Li,

Pan,

Yin

et al. 2024

IJMS

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Cadmium (Cd) is a heavy metal element with a wide range of hazards and severe biotoxicity. Since Cd can be easily accumulated in the edible parts of plants, the exposure of humans to Cd is mainly through the intake of Cd-contaminated food. However, the intestinal responses to Cd exposure are not completely characterized. Herein, we simulated laboratory and environmental Cd exposure by feeding the piglets with CdCl2-added rice and Cd-contaminated rice (Cdcr) contained diet, as piglets show anatomical and physiological similarities to humans. Subsequent analysis of the metal element concentrations showed that exposure to the two types of Cd significantly increased Cd levels in piglets. After verifying the expression of major Cd transporters by Western blots, multi-omics further expanded the possible transporters of Cd and found Cd exposure causes wide alterations in the metabolism of piglets. Of significance, CdCl2 and Cdcr exhibited different body distribution and metabolic rewiring, and Cdcr had stronger carcinogenic and diabetes-inducing potential. Together, our results indicate that CdCl2 had a significant difference compared with Cdcr, which has important implications for a more intense study of Cd toxicity.

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Section: Resultsmentioning

confidence: 99%

Integrating Transcriptomics and Proteomics to Characterize the Intestinal Responses to Cadmium Exposure Using a Piglet Model

Li,

Pan,

Yin

et al. 2024

IJMS

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“…The increased number of Cd sources and knowledge of its harmfulness are attracting evermore attention [3]. Therefore, finding possible ways to limit, prevent, and remediate Cd's hazardous effects has been the subject of a plethora of scientific studies [31,32]. The strategy of the application of microorganisms for the bio-removal of toxins and heavy metals has become favorable over the years.…”

Section: Discussionmentioning

confidence: 99%

Orally Administrated Lactiplantibacillus plantarum BGAN8-Derived EPS-AN8 Ameliorates Cd Hazards in Rats

Brdarić

Popović

Bajić

et al. 2023

IJMS

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Cadmium (Cd) is a highly toxic metal that is distributed worldwide. Exposure to it is correlated with a vast number of diseases and organism malfunctions. Exopolysaccharides (EPS) derived from Lactiplantibacillus plantarum BGAN8, EPS-AN8, previously showed great potential for the in vitro protection of intestinal cells from this metal. Here, we investigated the potential of food supplemented with EPS-AN8 to protect rats from the hazardous effects of Cd exposure. After thirty days of exposure to lower (5 ppm) and higher (50 ppm)-Cd doses, the administration of EPS-AN8 led to decreased Cd content in the kidneys, liver, and blood compared to only Cd-treated groups, whereas the fecal Cd content was strongly enriched. In addition, EPS-AN8 reversed Cd-provoked effects on the most significant parameters of oxidative stress (MDA, CAT, GST, and GSH) and inflammation (IL-1β, TNF-α, and IFN-γ) in the duodenum. Moreover, micrographs of the duodenum were in line with these findings. As the gut microbiota has an important role in maintaining homeostasis, we used 16S rRNA amplicon sequencing and investigated the effects of Cd and EPS-AN8 on one part of the microbiota presented in the duodenum. Although Cd decreased the growth of lactobacilli and mostly favored the blooming of opportunistic pathogen bacteria, parallel intake of EPS-AN8 reversed those changes. Therefore, our results imply that EPS-AN8 might be extremely noteworthy in combatting this toxic environmental pollutant.

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Vitamin E: An assistant for black soldier fly to reduce cadmium accumulation and toxicity

Shi,

Wan,

Peng

et al. 2024

Environment International

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Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression

Cited by 7 publications

References 65 publications

Integrating Transcriptomics and Proteomics to Characterize the Intestinal Responses to Cadmium Exposure Using a Piglet Model

Integrating Transcriptomics and Proteomics to Characterize the Intestinal Responses to Cadmium Exposure Using a Piglet Model

Orally Administrated Lactiplantibacillus plantarum BGAN8-Derived EPS-AN8 Ameliorates Cd Hazards in Rats

Vitamin E: An assistant for black soldier fly to reduce cadmium accumulation and toxicity

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