Zinc oxide nanoparticles attenuate the oxidative damage and disturbance in antioxidant defense system induced by cyclophosphamide in male albino rats

Shkal, Karema El M; Azab, Azab Elsayed; Attia, A. A.; El-Banna, Sabah G; Yahya, Rabia Am

doi:10.29328/journal.ibm.1001016

Cited by 5 publications

(7 citation statements)

References 50 publications

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“…There is a general trend of decrease in the antioxidant activity with increasing concentration. ZnO NPs decrease oxidative stress by reduction or radical scavenging due to the electron donation potential of the oxygen group in ZnO. , …”

Section: Resultsmentioning

confidence: 99%

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Bioinspired Stevia rebaudiana Green Zinc Oxide Nanoparticles for the Adsorptive Removal of Antibiotics from Water

Guirguis,

Youssef,

William

et al. 2024

ACS Omega

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Green zinc oxide nanoparticles (ZnO NPs) synthesized using Stevia rebaudiana as a reducing agent were investigated as ecofriendly adsorbents for the removal of the antibiotics ciprofloxacin (CIP) and tetracycline (TET) from water. Green ZnO NPs were synthesized using a rapid novel approach that did not require annealing or calcination at high temperatures to produce mesoporous NPs with a size range of 37.36−71.33 nm, a specific surface area of 15.28 m 2 /g, and a negative surface charge of −15 mV at pH 5. The green ZnO NPs exhibited an antioxidant activity of 85.57% at 250 μg/mL and an antibacterial activity with MIC and MBC of 50 and 100 mg/mL, respectively, against both Escherichia coli and Staphylococcus aureus. The best adsorption performance was achieved using a 4 g/L dose and pH 5, yielding, respectively, 86.77 ± 0.82% removal and 27.07 ± 0.26 mg/g adsorption capacity for CIP at 10 mg/L and 67.86 ± 3.41% and 15.88 ± 0.37 mg/g for TET at 25 mg/L. The green ZnO NPs achieved 79.71% ± 0.28 and 61.55% ± 0.53 removal of 10 mg/L CIP and 25 mg/L TET, respectively, in a spiked tap water binary system of the two contaminants. Adsorption of CIP and TET occurred mainly via electrostatic interactions, whereby CIP was bound more strongly than TET by virtue of its charge and size. The synthesis and adsorption processes were evaluated by a stepwise regression statistical model to optimize their parameters. Lastly, the green ZnO NPs were regenerated and reused for 5 cycles, indicating their functionality as simple, reusable, and low-cost adsorbents for the removal of CIP and TET from wastewater, in accordance with SDGs #6 and 12 for the sustainable management of water.

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Section: Resultsmentioning

confidence: 99%

“…ZnO NPs decrease oxidative stress by reduction or radical scavenging due to the electron donation potential of the oxygen group in ZnO. 72 , 77 …”

Section: Resultsmentioning

confidence: 99%

Bioinspired Stevia rebaudiana Green Zinc Oxide Nanoparticles for the Adsorptive Removal of Antibiotics from Water

Guirguis,

Youssef,

William

et al. 2024

ACS Omega

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“…Zinc oxide nanoparticles were used to modulate the potentials of oxidative stress in the tissues owing to the antioxidant properties and/or free radical scavenging capacity [ 44 , 45 ]. Ascorbic acid is a water-soluble, non-enzymatic antioxidant that protects cells from ROS by directly interacting with lipid peroxides, increasing GSH levels and antioxidant enzyme activity, and preventing the subsequent apoptosis [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Zinc Oxide Nanoparticles and Vitamin C Ameliorate Atrazine-Induced Hepatic Apoptosis in Rat via CYP450s/ROS Pathway and Immunomodulation

Mohammed

Safwat

Bahnasawy

et al. 2023

Biol Trace Elem Res

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Atrazine, as an herbicide, is used widely worldwide. Because of its prolonged persistence in the environment and accumulation in the body, atrazine exposure is a potential threat to human health. The present study evaluated the possible protective effects of zinc oxide nanoparticles and vitamin C against atrazine-induced hepatotoxicity in rats. Atrazine administered to rats orally at a dose of 300 mg/kg for 21 days caused liver oxidative stress as it increased malondialdehyde (MDA) formation and decreased reduced glutathione (GSH) contents. Atrazine induced inflammation accompanied by apoptosis via upregulation of hepatic gene expression levels of NF-κB, TNF-α, BAX, and caspase-3 and downregulation of Bcl-2 gene expression levels. Additionally, it disturbed the metabolic activities of cytochrome P450 as it downregulated hepatic gene expression levels of CYP1A1, CYP1B1, CYP2E1. The liver function biomarkers were greatly affected upon atrazine administration, and the serum levels of AST and ALT were significantly increased, while BWG%, albumin, globulins, and total proteins levels were markedly decreased. As a result of the above-mentioned influences of atrazine, histopathological changes in liver tissue were recorded in our findings. The administration of zinc oxide nanoparticles or vitamin C orally at a dose of 10 mg/kg and 200 mg/kg, respectively, for 30 days prior and along with atrazine, could significantly ameliorate the oxidative stress, inflammation, and apoptosis induced by atrazine and regulated the hepatic cytochrome P450 activities. Furthermore, they improved liver function biomarkers and histopathology. In conclusion, our results revealed that zinc oxide nanoparticles and vitamin C supplementations could effectively protect against atrazine-induced hepatotoxicity.

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“…H 2 O 2 contributes to cellular damage by reducing the activity of SOD in O 2 -generating systems [238]. Free radical generation and inflammation are known to cause high-level tissue-destruction mechanisms [239][240][241]. Therefore, a reduction in free radicals is crucial for curing various diseases.…”

Section: Therapeutic Role Of Zinc-based Nps (Znnps) and Their Antioxi...mentioning

confidence: 99%

“…Therefore, a reduction in free radicals is crucial for curing various diseases. Zinc oxide and its conjugated NPs, a known metal oxide commonly used in coatings, paints, and cosmetic products such as sunscreens, is currently valued for its potential antioxidant, anti-inflammatory, antibacterial, and UV-protection properties [241][242][243][244][245]. The hippocampus plays a vital role in cognitive processes such as learning and memory in both rodent and human populations [246].…”

Section: Therapeutic Role Of Zinc-based Nps (Znnps) and Their Antioxi...mentioning

confidence: 99%

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Patel,

Kevadiya,

Bajwa

et al. 2023

Antioxidants

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Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various cell organelles, such as mitochondria, endoplasmic reticulum, and Golgi complex, as well as physical and mental disturbances. The nervous system has a relatively high utilization of oxygen, thus making it particularly vulnerable to oxidative stress, which eventually leads to neuronal atrophy and death. This advances the development of neuroinflammation and neurodegeneration-associated disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy, dementia, and other memory disorders. It is imperative to treat such conditions as early as possible before they worsen and progress to irreversible damage. Oxidative damage can be negated by two mechanisms: improving the cellular defense system or providing exogenous antioxidants. Natural antioxidants can normally handle such oxidative stress, but they have limited efficacy. The valuable features of nanoparticles and/or nanomaterials, in combination with antioxidant features, offer innovative nanotheranostic tools as potential therapeutic modalities. Hence, this review aims to represent novel therapeutic approaches like utilizing nanoparticles with antioxidant properties and nanotheranostics as delivery systems for potential therapeutic applications in various neuroinflammation- and neurodegeneration-associated disease conditions.

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Zinc oxide nanoparticles attenuate the oxidative damage and disturbance in antioxidant defense system induced by cyclophosphamide in male albino rats

Cited by 5 publications

References 50 publications

Bioinspired Stevia rebaudiana Green Zinc Oxide Nanoparticles for the Adsorptive Removal of Antibiotics from Water

Bioinspired Stevia rebaudiana Green Zinc Oxide Nanoparticles for the Adsorptive Removal of Antibiotics from Water

Zinc Oxide Nanoparticles and Vitamin C Ameliorate Atrazine-Induced Hepatic Apoptosis in Rat via CYP450s/ROS Pathway and Immunomodulation

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

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