Zinc Oxide Nanoparticles: Green Synthesis and Biomedical Applications

Sadhasivam, Sahana; Shanmugam, M.; Umamaheswaran, Pillai Divya; Anbazhagan, V.; Shanmugam, Anusuya

doi:10.1007/s10876-020-01918-0

Cited by 32 publications

(29 citation statements)

References 145 publications

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“…The synthesized nanoparticles show the quality of anti-inflammatory activity in the range of 80-90%, respectively. All these data with results show that ZnO nanoparticle produced from Amla fruit potent anti-inflammatory property [46] ZnO-NPs using Kalanchoe pinnata leaf extract LPS induced murine macrophage RAW 264.7 cells RAW 264.7 cells were incubated with different concentrations of ZnO NPs (1, 0.5, 0.25, and 0.1) mg/mL for 24 h and cell viability relative percentage with control was calculated. Cells showed no significant toxicity up to the concentration of 1 mg/mL [47] ZnO-NPs ketoprofen in rats Ketoprofen at all the examined doses (5, 10, and 20 mg/kg) inhibits the carrageenan-induced paw edema by 40%-65% at the second and third hour after the administration of carrageenan.…”

Section: Anti-inflammatory Activitymentioning

confidence: 64%

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Green Synthesis of Zinc Oxide Nanoparticles and Its Biomedical Applications: A Review

Hamrayev

Shameli

Korpayev

2021

JRNN

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The rise of nanotechnology has brought to the world a new potential and broader perspective of what humanity can achieve through material manipulation at the nanoscale. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. Interestingly, the green method of synthesis using plant sources have been found appropriate for the production of ZnO NPs dues to its numerous health, environmental, economic, and medicinal benefits. Due to the large rate of toxic chemicals and extreme environment employed in the physical and chemical production of these nanoparticles, green methods employing the use of plants, fungus, bacteria, and algae have been adopted. Zinc oxide nanoparticles have been successfully obtained by green synthesis using different biological substrates. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis. This review summarizes the green synthesis and recent advances of ZnO NPs in the biomedical fields, which will be helpful for facilitating their future research progress and focusing on biomedical fields.

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Section: Anti-inflammatory Activitymentioning

confidence: 64%

“…The arterioles in the surrounding tissue dilate when there is harm to any part of the body. This gives redness because of the raised blood circulation toward the area [46]. Inflammation could be either acute or chronic inflammation.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Green Synthesis of Zinc Oxide Nanoparticles and Its Biomedical Applications: A Review

Hamrayev

Shameli

Korpayev

2021

JRNN

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“…Zinc nanoparticles have been widely used in engineering and science applications [51,52]. The antimicrobial characteristics of ZnO NPs (antibacterial and antifungal) have piqued interest, particularly in the biomedical field [53].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the biocompatibility and corrosion behaviour of pure Mg,Mg Ni/Ti, and Mg 0.4Ce/ZnO₂ nanocomposites for orthopaedic implant applications

Meenachi¹,

Subashini²,

Lakshminarayanan³

et al. 2023

Mater. Res. Express

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Magnesium implants that are biocompatible and biodegradable are important for orthopaedic applications. Mg-based alloys and their corrosion behavior have been studied in vitro and in a few in vivo studies. However, depending on the composition and microstructure, Mg-based alloys display varied biocompatibility, degradability, biocompatibility, and bioactivity. As a result, there is a critical need to create safe and cost-effective magnesium alloys for orthopaedic applications. The current investigation examined cytotoxicity, hemocompatibility, in vitro corrosion, and biomineralization of pure Mg, Mg Ni/Ti, and Mg 0.4Ce/ZnO2 nanocomposites to establish its suitability as a biodegradable material. The biodegradation behaviour of pure Mg and its nanocomposites were investigated using a phosphate buffer solution. The Cytotoxicity of pure Mg and its nanocomposites were assessed using MG 63 cells in MTT (3-(4, 5-dimethyl-2-thiazolyl)-2,5 diphenyltetrazolium bromide) assays after 24 hrs. Biomineralization by MG 63 cells on pure Mg and its nanocomposites were analyzed using Alizarin red staining. The in vitro corrosion findings indicate more localized corrosion with rapid degradation on the surface of pure Mg and its nanocomposites. Pure Mg and its nanocomposites exhibited high hemolysis. The results of cytotoxicity showed high cell viability in pure Mg compared to its nanocomposites. According to the Alizarin red staining results, calcium was found to be deposited on the surface of Mg nanocomposites, and no calcium deposits on the pure Mg surface. The results of in vitro studies revealed that pure Mg and its nanocomposites responded differently in different tests. From these results, comparing Mg nanocomposites could be a more effective strategy to address the current challenges in orthopaedic implant applications.

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“…Zinc oxide has gained researcher's interest as it shows unique optical, chemical sensing, semiconducting, and piezoelectric properties due to its wide bandgap of 3.3 eV [3]. Besides, this zinc oxide and other metal oxides are widely used in biomedical applications [4]. Zinc oxide nanoparticles (ZnO NPs) are biosafe and act as a strong antibacteria for both gram-negative and gram-positive bacteria, and their antibacterial properties vary with the size of particles [5,6].…”

Section: Introductionmentioning

confidence: 99%

Variation in the Performance of MWCNT/ZnO Hybrid Material with pH for Efficient Antibacterial Agent

Rafique

Bashir

Akram

et al. 2022

BioMed Research International

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In the present work, multiwalled carbon nanotube (MWCNT)/zinc oxide (ZnO) nanoparticles at pH 6.0, 7.0, 8.0, and 10.0 were prepared through the coprecipitation method to improve the antibacterial activity. Morphological, structural, and optical analysis, such as Fourier transform infrared spectroscopy, X-ray diffraction, and field emission scanning electron microscopy, was used to investigate the formation of composites. Analysis revealed that there were variations in morphology from agglomerated structures to rod-like then flower-like structures as pH varied from 6.0 to 10.0. The MWCNT/ZnO composite enhanced the antibacterial activity especially for Staphylococcus aureus as a maximum 20 mm zone of inhibition was observed. The data presented in the present study proves that such composites are an efficient antibacterial agent and suitable for therapy for severe infections.

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Zinc Oxide Nanoparticles: Green Synthesis and Biomedical Applications

Cited by 32 publications

References 145 publications

Green Synthesis of Zinc Oxide Nanoparticles and Its Biomedical Applications: A Review

Green Synthesis of Zinc Oxide Nanoparticles and Its Biomedical Applications: A Review

Comparative study of the biocompatibility and corrosion behaviour of pure Mg,Mg Ni/Ti, and Mg 0.4Ce/ZnO₂ nanocomposites for orthopaedic implant applications

Variation in the Performance of MWCNT/ZnO Hybrid Material with pH for Efficient Antibacterial Agent

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Zinc Oxide Nanoparticles: Green Synthesis and Biomedical Applications

Cited by 32 publications

References 145 publications

Green Synthesis of Zinc Oxide Nanoparticles and Its Biomedical Applications: A Review

Green Synthesis of Zinc Oxide Nanoparticles and Its Biomedical Applications: A Review

Comparative study of the biocompatibility and corrosion behaviour of pure Mg,Mg Ni/Ti, and Mg 0.4Ce/ZnO2 nanocomposites for orthopaedic implant applications

Variation in the Performance of MWCNT/ZnO Hybrid Material with pH for Efficient Antibacterial Agent

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Comparative study of the biocompatibility and corrosion behaviour of pure Mg,Mg Ni/Ti, and Mg 0.4Ce/ZnO₂ nanocomposites for orthopaedic implant applications