Zinc oxide nanoparticles in predicted environmentally relevant concentrations leading to behavioral impairments in male swiss mice

Souza, Joyce Moreira de; Mendes, Bruna de Oliveira; Guimarães, Abraão Tiago Batista; Rodrigues, Aline Sueli de Lima; Chagas, Thales Quintão; Rocha, Thiago Lopes; Malafaia, Guilherme

doi:10.1016/j.scitotenv.2017.09.051

Cited by 45 publications

(16 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown the cytotoxic and genotoxic damages caused by progressive Zn accumulation and distribution in the cytoplasm and nucleus of A. cepa (Kumari et al, 2011;Sun et al, 2019) and Vicia faba cells (Ghosh et al, 2016) after to exposure to high concentrations of ZnO NPs. Based on the present results, we can assume that low increase in accumulated Zn rates after the exposure to very low concentrations of ZnO NPs can have significant biological effect on plants and animals (Mesak et al, 2018;Souza et al, 2018).…”

Section: Bioaccumulation Analysissupporting

confidence: 55%

“…The herein used ZnO NPs (purity>99.99%) were purchased at Sigma Aldrich (Saint Louis, MO, USA; CAS number 1314-13-2). The chemical characterization, the distribution of the individual diameter of each ZnO NP, X-ray diffraction patterns of the crystal quality of ZnO nanoparticles and fourier transform-infrared transmission spectra were previously calculated by the research group (Souza et al, 2018). ZnO NPs showed no trace of impurity, but they presented crystalline morphology and polygonal particles, as well as diameter consistent with the manufacturer's recommendations: 68.96 ± 33.71 nm.…”

Section: Chemical Characterization Of Zno Npsmentioning

confidence: 85%

“…Although the aforementioned studies are relevant for environmental monitoring, they report the toxic effects of ZnO NPs at concentrations far from those found in the field; therefore, these concentrations are much higher than the ones found in the environment (Boxall et al, 2007;Gottschalk et al, 2013;Dumont et al, 2015). The literature still lacks studies focused on evaluating the cytotoxic and genotoxic effects of the exposure to environmentally relevant concentrations of NPs, except for Souza et al, (2018) and Mesak et al, (2018), who showed behavioral changes in mammals and birds due to the exposure to such concentration rates.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to Allium cepa root cells

Sampaio¹,

Bogea²,

Neves³

et al. 2021

Genet. Mol. Res.

View full text Add to dashboard Cite

Although environmental toxicity of high concentrations of nanoparticles (NP) is well reported in the literature, information about their effects on biological systems at environmentally relevant concentrations remains scarce. We investigated whether low ZnO-NP concentrations influence the dynamics of cell division processes, cause nuclear abnormalities and induce changes in the genomic DNA using Allium cepa root cells. Healthy A. cepa bulbs were exposed to environmentally relevant concentrations of ZnO-NP for 48 hours under four different environmental conditions, namely: optimistic, median, pessimistic and known toxic. Mitotic index (MI), chromosomal abnormalities (CAs) and genomic stability based on DNA markers were estimated. ZnO-NPs induced significant changes in MI and CAs, with clear dose-response effects, even at very low concentrations and short exposure times. This outcome is clear evidence of negative effects. In addition, we evidenced instability in the repair mechanism of DNA mutated due to low concentrations of ZnO NPs based on RAPD-PCR ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 20 (1): gmr18690 L.L.G. Sampaio et al. 2results. Therefore, even short-term exposure of eukaryotic cells to low concentrations of ZnO-NP can damage cells and, consequently, negatively affect their biological functioning.

show abstract

Section: Bioaccumulation Analysissupporting

confidence: 55%

Section: Chemical Characterization Of Zno Npsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to Allium cepa root cells

Sampaio¹,

Bogea²,

Neves³

et al. 2021

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…In line, no damage to BBB or the brain, nor behavioural changes were observed after 28-day oral exposure of ZnO NPs [112]. In turn, de Souza et al demonstrated that environmentally relevant concentration of ZnO NPs cause behavioral changes of male Swiss mice [113]. Also Aijie et al reported injury in cerebral cortex and hippocampus and impaired learning and memory of rats administered with NPs ZnO and TiO 2 .…”

Section: In Vivo Toxicity In Mammalsmentioning

confidence: 99%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

View full text Add to dashboard Cite

Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry and medicine. Therefore, for many years a growing interest has been observed among the scientific community in the improvement of our understanding of the impact of nanoparticles on the living organisms, especially on humans. Considering the delicate structure of the central nervous systemit is one of the organs most vulnerable to the adverse effects of metallic nanoparticles. For that reason, it is important to identify the modes of exposure and understand the mechanisms of the effect of nanoparticles on neuronal tissue. In this review, an attempt is undertaken to present current knowledge about metallic nanoparticles neurotoxicity based on the selected scientific publications. The route of entry of nanoparticles is described, as well as their distribution, penetration through the cell membrane and the blood-brain barrier. In addition, a study on the neurotoxicity in vitro and in vivo is presented, as well as some of the mechanisms that may be responsible for the negative effects of metallic nanoparticles on the central nervous system. Graphical abstract: This review summarizes the current knowledge on the toxicity of metallic NPs in the brain and central nervous system of the higher vertebrates.

show abstract

“…Para los modelos predictivos de depresión como el test de natación forzada y el test de suspensión de la cola se corrobora el efecto antidepresivo del fármaco ISRS para dosis mayores de 16 mg ya que muestran mayor sensibilidad en el tiempo de inmovilidad tal como lo indica Karim y colaboradores en su estudio del efecto antidepresivo de fluoxetina (Karim et al, 2018), y otros trabajos donde utilizaron una dosis antidepresiva del fármaco como control positivo para sus estudios. ( Souza et al, 2018;Umathe et al, 2011).…”

Section: Discussionunclassified

Acción psicofarmacológica y analgésica del antidepresivo inhibidor selectivo de la recaptación de serotonina fluoxetina en ratón hembra

et al. 2020

View full text Add to dashboard Cite

El objetivo de este estudio es dar a conocer el rango de potencia relacionado con la dosificación del ISRS (inhibición selectiva de la recaptación de serotonina) fluoxetina y su mecanismo de acción como agente capaz de inducir efecto analgésico y ansiolítico en ratón hembra cepa CD-1 (25-39 kg). Los datos obtenidos mostraron que las dosis antidepresivas 16, 32, 64 mg/kg (i.p.) presentan efecto analgésico y una respuesta ansiolítica, sin resultado significativo en el modelo de memoria espacial, pero con una disminución en la actividad realizada en la memoria de trabajo para la dosis de 64 mg/kg (i.p.). Esto evidencia que fluoxetina puede orientar mayor eficacia a dosis con efecto antidepresivo e indica un efecto analgésico y ansiolítico sin producir cambio en la actividad motora del ratón. La dosis máxima investigada provocó variación en su actividad motora lo cual permite concluir que ISRS "fluoxetina" tiene un posible efecto sedativo.

show abstract

Zinc oxide nanoparticles in predicted environmentally relevant concentrations leading to behavioral impairments in male swiss mice

Cited by 45 publications

References 69 publications

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to <i>Allium</i> <i>cepa</i> root cells

Research Article Zinc oxide nanoparticles at environmentally relevant concentrations cause cytotoxic and chromosomal damage to <i>Allium</i> <i>cepa</i> root cells

Toxicity of metallic nanoparticles in the central nervous system

Acción psicofarmacológica y analgésica del antidepresivo inhibidor selectivo de la recaptación de serotonina fluoxetina en ratón hembra

Contact Info

Product

Resources

About