Zinc Oxide Nanoparticles Induced Oxidative DNA Damage, Inflammation and Apoptosis in Rat’s Brain after Oral Exposure

Attia, Hala; Nounou, Howaida A.; Shalaby, Manal

doi:10.3390/toxics6020029

Cited by 113 publications

(57 citation statements)

References 86 publications

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“…In addition, the study showed a significant increase in the cerebral levels of IFN-in the treated animals [27]. Oxidative stress was also attributed to adverse effects in brain tissue, such as increased inflammatory cytokines, DNA fragmentation and stimulation of apoptosis, in rats exposed orally for 7 days to ZnO NPs [149]. Chen et al observed in human brain microvascular endothelial cells that oxidative stress, manifested as decreased mitochondrial potential and decreased the expression of TJ proteins, is also induced by Al NPs [18].…”

Section: The Role Of Oxidative Stress In Nps-induced Toxicity and Dnamentioning

confidence: 88%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

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Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry and medicine. Therefore, for many years a growing interest has been observed among the scientific community in the improvement of our understanding of the impact of nanoparticles on the living organisms, especially on humans. Considering the delicate structure of the central nervous systemit is one of the organs most vulnerable to the adverse effects of metallic nanoparticles. For that reason, it is important to identify the modes of exposure and understand the mechanisms of the effect of nanoparticles on neuronal tissue. In this review, an attempt is undertaken to present current knowledge about metallic nanoparticles neurotoxicity based on the selected scientific publications. The route of entry of nanoparticles is described, as well as their distribution, penetration through the cell membrane and the blood-brain barrier. In addition, a study on the neurotoxicity in vitro and in vivo is presented, as well as some of the mechanisms that may be responsible for the negative effects of metallic nanoparticles on the central nervous system. Graphical abstract: This review summarizes the current knowledge on the toxicity of metallic NPs in the brain and central nervous system of the higher vertebrates.

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Section: The Role Of Oxidative Stress In Nps-induced Toxicity and Dnamentioning

confidence: 88%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

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“…It has been proven that nanoparticles may cause some degree of damage to the blood-brain barrier leading to increased permeability and facilitating its penetration into the central nervous system (CNS) [185]. Similarly, AgNP and ZnONP toxicity was also associated with the accumulation of nanoparticles in the brain, responsible for some degree of neuroinflammation and neurodegeneration caused by ROS induced CNS injury [186].…”

Section: Neurotoxicitymentioning

confidence: 99%

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

et al. 2020

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Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to a specific receptor in the bacterial cell) which not only makes the development of resistance by bacteria difficult, but also broadens the spectrum of antibacterial activity. As a result, a large majority of metal-based nanoparticles efficacy studies performed so far have shown promising results in both Gram-positive and Gram-negative bacteria. The aim of this review has been a comprehensive discussion of the state of the art on the use of the most relevant types of metal nanoparticles employed as antimicrobial agents. A special emphasis to silver nanoparticles is given, while others (e.g., gold, zinc oxide, copper, and copper oxide nanoparticles) commonly used in antibiotherapy are also reviewed. The novelty of this review relies on the comparative discussion of the different types of metal nanoparticles, their production methods, physicochemical characterization, and pharmacokinetics together with the toxicological risk encountered with the use of different types of nanoparticles as antimicrobial agents. Their added-value in the development of alternative, more effective antibiotics against multi-resistant Gram-negative bacteria has been highlighted.

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“…On the other hand, there are several accurate statements, which are approving the apoptotic activity of ZnONPs due to their ability to increase the intracellular ROS levels . According to our findings and both Hala Attia et al and Masoud Negahdary researches indicating the impacts have ZnONPs on decreasing the cellular antioxidant enzymes (GSH, CAT, and SOD), we suggest the ZnONPs mechanism is based on their ability in inducing apoptosis by down‐regulating the antioxidant enzymes and thus disabling the cells in controlling the amounts of ROS in human breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Green‐synthesized Zinc oxide nanoparticle, an efficient safe anticancer compound for human breast MCF7 cancer cells

Salari

Neamati

Tabrizi

et al. 2019

Applied Organom Chemis

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There are many types of researches investigating anticancer therapeutics for breast cancer therapy. Zinc oxide nanoparticles (ZnONPs) as an efficient drug delivery system, has been widely being used in various biomedical applications. In the current study, we synthesized ZnONP applying Rheum rhaponticum Waste (RRW) as a novel bio‐platform to investigate its anticancer impacts on MCF7 breast cancer cells compared with normal Human HFF and HDF cells. In this regard, RRW was triggered to synthesize the ZnONPs. Then, they were characterized by XRD, FTIR, TEM, and SEM analysis. Next, the MCF‐7, HFF, and HDF cell lines were cultured and treated as the following plane: Incubation of all cell lines for 72, 48, and 24 hours at the presence of different ZnONPs doses. Finally, the cell morphology, BCL2‐ BAX genes expression profile and AO/PI‐fluorescent cell staining on the 48‐hour incubated cells were analyzed to check the ZnONP apoptotic activity. Moreover, the ZnONP antioxidant activity was analyzed by a DPPH antioxidant test. We produced the 30 nm ZnONPs which significantly increased the BAX and decreased the BCL‐2 gene expression. According to the results including the Sub G1 enhancement peaks, apoptotic hallmarks, MTT assay, and the AO/PI‐fluorescent stained cells, ZnONPs can specifically induce apoptotic death in MCF7 breast cancer cells compared with normal HFF and HDF cells. The IC50 values of MCF‐7 in 72, 48, and 24 hr were measured at 8, 11, and 12 μg/ml in 72, 48, and 24 hr, respectively. This is while the mentioned values in the normal cells (HFF, HDF) were estimated at higher treatment doses. In conclusion, we suggest that the ZnONPs have the potential to be applied as a safe cell‐specific apoptosis inducer in breast cancer treatment. However, there are many challenges that need to be clarified for applying them as an efficient anticancer agent.

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Zinc Oxide Nanoparticles Induced Oxidative DNA Damage, Inflammation and Apoptosis in Rat’s Brain after Oral Exposure

Cited by 113 publications

References 86 publications

Toxicity of metallic nanoparticles in the central nervous system

Toxicity of metallic nanoparticles in the central nervous system

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

Green‐synthesized Zinc oxide nanoparticle, an efficient safe anticancer compound for human breast MCF7 cancer cells

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