Zinc oxide nanoparticles prevent multidrug resistant<i>Staphylococcus-</i>induced footpad dermatitis in broilers

Mahmoud, Usama M.; Darwish, Madeha; Ali, Fatma Abo Zakaib; Amen, Omar; Mahmoud, Magdy S.; Ahmed, Omar Bauomy; El-Reda, Ghada Abd; Osman, M.A.; Othman, A.A.; Abushahba, Mostafa F. N.; Shoukary, Ramadan D. El

doi:10.1080/03079457.2021.1875123

Cited by 15 publications

(12 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore the severity of of each lesion was scored as follows: 0 = no lesions; 1 = minimal (1–10% of the tissue section affected); 2 = mild (11–25%); 3 = moderate (26–45%) and 4 = severe (> 45%) 21 , 22 , 24 .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of cultured white soft cheese on the histopathological changes in the kidneys and liver of albino rats

Salman

Ali

Elhanbaly

2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Three different types of lactic acid bacteria (Lactobacillus helveticus, Lactobacillus rhamnosus and Streptococcus thermophilus S3855) were used to manufacture white soft cheese. The resultant white soft cheeses were pickled for 28 days at refrigerator temperatures and were fed to the experimental rats. The chemical and microbiological analyses of white soft cheese were conducted at different storage periods (fresh, 7 days, 14 days, 21 days, and 28 days). The pH values and protein content of white soft cheese gradually decreased during the storage peroid. Conversely, the moisture content, titratable acidity, and fat/DM % of white soft cheese were found to increase with of the increase in pickling periods of up to 28 days. Microbiologically, the total viable count of bacteria in the control samples was lower than that in the other treatments. Furthermore, the treatments containing the L. helveticus and L. rhamnosus strains had the highest lactoacilli counts whereas the treatment containing the S. thermophilus strain had the highest streptococci counts. Twenty-five male Albino rats were used for experiemntal technique. Rats were fed with 70% basal diet with addition of 30% white soft cheese. Several pathological findings were present in all experimental groups apart from the control rats, and the kidney samples exhibited renal vascular congestion especially in the cortical area. The changes of the glomeruli comprise atrophy, distortion, hypocellularity of the glomerular tuft, and focal lymphoid cell reactions. The renal tubular epithelium showed a series of degenerative changes ranging up to necrosis. The liver samples showed variable hepatic injury in the form of thickening in the Glisson capsule, as well as dissociation and disorganization of hepatic cords. Hepatocellular vacuolar degeneration, presence of focal areas of nodular hyperplasia, the hyperplastic cells mixed with lymphocytic infiltration, congestion in the portal vein, periportal fibrosis and edema with the presence of newly formed nonfunctional bile ductulus. Based on the histopathology scores, the severity of renal and hepatic changes was significantly increased (P ≤ 0.05) in all of the experimental groups compared with the control group. Generally, the chemical composition, microbiological analysis and vital organs were significantly affected by using cultured white soft cheese.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The measurements obtained from the experimental groups were statistically estimated via GraphPad Prism (version 5) (San Diego, California, USA) using one‑way ANOVA with Tukey’s post hoc multiple comparison tests. A P value of P < 0.05 was considered statistically significant 22 , 24 .…”

Section: Methodsmentioning

confidence: 99%

Effect of cultured white soft cheese on the histopathological changes in the kidneys and liver of albino rats

Salman

Ali

Elhanbaly

2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…ZnO NPs of 60 nm showed superb antibacterial activity against E. coli , S. aureus and MRSA reflected in zones of inhibition of 22 ± 03 mm, 21 ± 02 mm and 17 ± 02 mm, respectively, which was comparable with antibacterial activity of AgNPs of 50 nm [ 313 ]. Using ZnO NPs as strong antibacterial and antibiofilm agents against MDR MRSA and their biofilm-associated disease was recommended by Abd El-Hamid et al [ 314 ] ZnO NPs were also reported to prevent MRSA-induced footpad dermatitis in broilers and can be used as dietary supplements [ 315 ]. Comparison of the properties of ZnO NPs (17.11–22.56 nm) prepared under different light regimes showed that ZnO NPs synthesized under a green light exhibited the highest free radical quenching and cation radical scavenging activities; those prepared under red, green and blue light exhibited considerable inhibition of amylase, lipase, and urease; ZnO NPs prepared under daylight showed superior total reducing potential and metal-chelating activity; and the most effective antibacterial activity against MRSA was observed with ZnO NPs fabricated under blue light [ 316 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

View full text Add to dashboard Cite

Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

show abstract

“…There are several examples of laboratory-made mineral nanoparticles, which were tested as feed additives. They include the following types Ag (Ognik et al 2016a ; Abdelsalam et al 2019 ; Dung et al 2020 ; Kumar and Bhattacharya 2019 ; Awaad et al 2021 ), Au (Sembratowicz et al 2016 ; Hassanen et al 2020 ), Ca (Abo El-Maaty et al 2021 ), Cu (Gonzales-Eguia et al 2009 ; Miroshnikov et al 2015 ; Refaie et al 2015 ; Joshua et al 2016 ; Ognik et al 2016b ; Morsy et al 2021 ), Se (Sadeghian et al 2012 ; Joshua et al 2016 ; Gangadoo et al 2018 ; Gangadoo et al 2020 ; Sheiha et al 2020 ), and Zn (Joshua et al 2016 ; Bakhshizadeh et al 2019 ; Kociova et al 2020 ; Hidayat et al 2021 ; Mahmoud et al 2021 ; Ouyang et al 2021 ).…”

Section: Production Of Nanoparticles For Animal Researchmentioning

confidence: 99%

“…Pineda et al ( 2012 ) used in broiler chickens feed silver nanoparticles also produced by a non-explosive high voltage method (Polish Patent 3883399) from high purity metals and demineralized water. Mahmoud et al ( 2021 ) checked if zinc oxide (ZnO) nanoparticles, prepared by mechanical milling of a commercial ZnO with a planetary ball mill (Othman et al 2018 ), can prevent multi-drug resistant Staphylococcus -induced footpad dermatitis in broilers. In summary, physical methods are most often used to produce copper nanoparticles that were mainly applied as feed additives for poultry.…”

Section: Production Of Nanoparticles For Animal Researchmentioning

confidence: 99%

The effect of metal-containing nanoparticles on the health, performance and production of livestock animals and poultry

Michalak

Dziergowska

Alagawany

et al. 2022

Veterinary Quarterly

View full text Add to dashboard Cite

The application of high doses of mineral feed additives in the form of inorganic salts increases the growth performance of animals, but at the same, due to their low bioavailability, can contaminate the environment. Therefore, there is a need to find a replacement of administering high doses of minerals with an equally effective alternative. The application of lower doses of metal-containing nanoparticles with the same effect on animal production could be a potential solution. In the present review, zinc, silver, copper, gold, selenium, and calcium nanoparticles are discussed as potential feed additives for animals. Production of nanoparticles under laboratory conditions using traditional chemical and physical methods as well as green and sustainable methods – biosynthesis has been described. Special attention has been paid to the biological properties of nanoparticles, as well as their effect on animal health and performance. Nano-minerals supplemented to animal feed (poultry, pigs, ruminants, rabbits) acting as growth-promoting, immune-stimulating and antimicrobial agents have been highlighted. Metal nanoparticles are known to exert a positive effect on animal performance, productivity, carcass traits through blood homeostasis maintenance, intestinal microflora, oxidative damage prevention, enhancement of immune responses, etc. Metal-containing nanoparticles can also be a solution for nutrient deficiencies in animals (higher bioavailability and absorption) and can enrich animal products with microelements like meat, milk, or eggs. Metal-containing nanoparticles are proposed to partially replace inorganic salts as feed additives. However, issues related to their potential toxicity and safety to livestock animals, poultry, humans, and the environment should be carefully investigated.

show abstract

Zinc oxide nanoparticles prevent multidrug resistantStaphylococcus-induced footpad dermatitis in broilers

Cited by 15 publications

References 61 publications

Effect of cultured white soft cheese on the histopathological changes in the kidneys and liver of albino rats

Effect of cultured white soft cheese on the histopathological changes in the kidneys and liver of albino rats

Advances in Nanostructures for Antimicrobial Therapy

The effect of metal-containing nanoparticles on the health, performance and production of livestock animals and poultry

Contact Info

Product

Resources

About