Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism

Król, Anna; Pomastowski, Paweł; Rafińska, Katarzyna

doi:10.1016/j.cis.2017.07.033

Cited by 568 publications

(300 citation statements)

References 204 publications

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“…[24] CuO nanostructures are bioactive and produce anti-proliferation or anti-migration effects in cancerc ells. tubulin,a ctin filament bundling and microtubule network reorganization are observed, resulting in necrosis and apoptosis.…”

Section: Metallic Compoundsmentioning

confidence: 99%

“…[20] For instance, Ni-Til ayered double hydroxide (Ni-TiL DH) can spontaneously produce hydroxyl radicals and ROS by the Ni 2 + /Ni 3 + redox reaction [21] to inhibit growth of variousb acteria and cancerc ells but without showing adversee ffects for normal cells. [24] The general mechanisms governing the inherentc hemotherapeutic bioactivity induced by LDNs include ROS generation induced oxidative stress, [25] intracellulari on imbalance, [26] and chargeinterference of chain complexes. [24] The general mechanisms governing the inherentc hemotherapeutic bioactivity induced by LDNs include ROS generation induced oxidative stress, [25] intracellulari on imbalance, [26] and chargeinterference of chain complexes.…”

Section: Introductionmentioning

confidence: 99%

“…Bioactivity-related anti-cancer effects have also been observed for calcium phosphate nanoceramics, [22] graphene derivatives, [23] and zinc oxide nanocomposites. [24] The general mechanisms governing the inherentc hemotherapeutic bioactivity induced by LDNs include ROS generation induced oxidative stress, [25] intracellulari on imbalance, [26] and chargeinterference of chain complexes. [27] To the best of our knowledge,acomprehensive review discussing the selective chemotherapeutic effectso fL DNs arising from the inherent chemical activityo rbioactivity has not been published.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

Zhou

Chu

et al. 2019

Chemistry A European J

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Low-dimensional nanomaterials (LDNs) are receiving increasing attention in cancert herapy owing to their unique properties, especially the large surfacea rea-tovolume ratio. LDNs such as metallicn anoparticles (NPs), hydroxyapatite NPs, graphene derivatives, and black phosphorus (BP) nanosheets have been proposed for drug delivery, photothermal/photodynamic therapies, andm ultimodal theranostict reatments. The therapeutic effectiveness is mainly based on the physical characteristics of LDNs, but their inherent bioactivity has not been fully capitalized. In this Minireview,r ecent advances in the anti-cancer effects of varioust ypes of LDNs with inherentc hemotherapeutic bioactivity are described and the bioactivity mechanismsa re discussed on the cellular and molecular levels.B P, one of the newesta nd exciting members of the LDN family,i sh ighlighted owing to the excellent inherent bioactivity,s electivity,a nd biocompatibility in cancert herapy.L DNs and related derivatives possess inherentb ioactivity and selective chemotherapeutic effects suggesting large potentiala sn anostructured anti-cancer agentsinc ancer therapy.

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Section: Metallic Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

Zhou

Chu

et al. 2019

Chemistry A European J

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“…In the last decade, ZnO semiconductor has received great attention in a wide range of applications, due to its excellent properties, including low cost, high redox potential, nontoxicity, and its extraordinary characteristics in electronics, photonics, and optics . It showed potential in biomedical applications such as antidiabetic, antifungal, anti‐inflammatory, and antioxidant . ZnO NPs possess good thermal stability and biocompatibility and high antimicrobial activity which make it a promising antibacterial agent with excellent activity in a wide spectrum of bacteria .…”

Section: Introductionmentioning

confidence: 99%

Recent advance in antibacterial activity of nanoparticles contained polyurethane

Farrokhi

Ayati

Kanvisi

et al. 2018

J of Applied Polymer Sci

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Polyurethanes (PUs) are among the most widely used polymers with various applications in several industries. Antibacterial activity is an important feature of PU materials used in medical or many other related consumer products. They can, however, be easily colonized by bacteria and fungi, which may cause many problems for human health. It is therefore very important to enhance the antimicrobial properties of PUs, besides improving their chemical and physical properties. The incorporation of some antibacterial materials in the PUs' polymeric matrices is an effective strategy to improve their antibacterial activity. In this regard, the addition of some materials including Ag, Au, ZnO, and TiO2 nanoparticles, carbon nanotubes and chitosan to the PUs' material structure is reviewed in this article, and their antibacterial mechanisms are discussed. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46997.

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“…However, the NPs are able to be oxidized, reduced, or dissolved and are cytotoxic and genotoxic for cells(Auffan, Rose, Wiesner, & Bottero, 2009). In turn, these ROS can induce DNA damage, but NPs may also bind with DNA molecules and disrupt the helical structure(Ingle, Duran, & Rai, 2014;Król, Pomastowski, Rafińska, Railean-Plugaru, & Buszewski, 2017;Rai et al, 2018). Nevertheless, the cell wall composition influenced the antibacterial activity of metallic NPs.…”

mentioning

confidence: 99%

In vitro antimicrobial effect of metallic nanoparticles on phytopathogenic strains of crop plants

Vera‐Reyes

Esparza‐Arredondo²,

Lira-Saldívar³

et al. 2019

Journal of Phytopathology

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In this research, the in vitro antimicrobial effect of zinc oxide (ZnO), copper oxide (CuO) and iron oxide (Fe2O3) nanoparticles (NPs)—with average sizes of 20, 46 and 30 nm, respectively—on the root rot disease caused by the fungus Fusarium oxysporum and on blight disease caused by the fungus Alternaria solani were studied. Also, bacterial diseases caused by Clavibacter michiganensis and Pseudomonas syringae that infects a wide range of plant species were assessed. Different concentrations of NPs (0, 100, 250, 500, 700 and 1,000 mg/L) were prepared on PDA agar or King's B medium in a complete randomized design with four replicates. According to the results, ZnO NPs exhibited an outstanding inhibitory effect against fungi and bacteria strains. The above results were associated with the smaller particle size. Fungi strains showed a differential sensitivity depending on the kind of NPs used. A. solani showed the highest sensitivity to ZnO NPs at 1,000 mg/L (99%), followed by CuO NPs at the same dose (95%). Fe2O3 NPs at all evaluated doses had no inhibitory effects on the mycelia growth of this strain, although F. oxysporum revealed greater effectiveness of the CuO NPs (96%) compared with ZnO NPs since it only inhibited 91% of the mycelial growth. The antibacterial activity was studied through optical density. C. michiganensis was found to be more sensitive to ZnO NPs because a lesser dose (700 mg/L) was required to reduce the bacterial growth (90%); in comparison, P. syringae required a dose of 1,000 mg/L to inhibit its growth (67%). CuO NPs displayed the smallest growth inhibition against the bacteria strains analysed. The antimicrobial effect of the metallic NPs that were assayed increased with higher doses.

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Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism

Cited by 568 publications

References 204 publications

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

Inherent Chemotherapeutic Anti‐Cancer Effects of Low‐Dimensional Nanomaterials

Recent advance in antibacterial activity of nanoparticles contained polyurethane

In vitro antimicrobial effect of metallic nanoparticles on phytopathogenic strains of crop plants

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