Zinc oxide nanoparticles synthesized from Fraxinus rhynchophylla extract by green route method attenuates the chemical and heat induced neurogenic and inflammatory pain models in mice

Wang, Zhi; Que, Bin; Gan, Jianhui; Guo, Hao; Chen, Qiang; Zheng, Lemin; Marraiki, Najat; Elgorban, Abdallah M.; Zhang, Yi

doi:10.1016/j.jphotobiol.2019.111668

Cited by 20 publications

(9 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…WGE ZnO NPs amend the release of protein and expression of inflammation by hindering the NF‐KB pathway. Synthesis and release of NO are also suppressed, which has a crucial role in the pathogenesis of various inflammatory disorders [60] …”

Section: Resultsmentioning

confidence: 99%

“…Synthesis and release of NO are also suppressed, which has a crucial role in the pathogenesis of various inflammatory disorders. [60] Anticancer activity WGE ZnO NPs were very effective anticancer agents, as the Zn + 2 ions released by them induce ROS resulting in the apoptosis of the malignant cells through oxidative stress mechanism. From the cell culture analysis and experimental data, it is observed that the extract which is obtained after 50 mL extractions were detected to be very active in hindering the viability of breast cancer cells even at a low concentration ranging from 50 μg/mL to 400 μg/mL.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

See 1 more Smart Citation

Visible Light Driven Photodegradation of Pathological Effluents and Biological Evaluation of Green ZnO Nanoparticles

et al. 2022

View full text Add to dashboard Cite

ZnO nanoparticles (NPs) are biosynthesized for the first time with the aqueous wheatgrass extract (WGE) using the solution combustion method. The synthesized nanoparticles were characterized by XRD, SEM, TEM, DLS, TGA, UV‐Vis. and FTIR. The synthesized ZnO NPs were crystalline, having a wurtzite structure, with an average particle size of 25 nm, confirmed from TEM and DLS. The biosynthesized ZnO NPs from WGE has shown excellent activity against Gram‐positive and Gram‐negative bacteria. They also exhibited good antioxidant and anti‐inflammatory activities with IC50 value of 4.63 μg/mL. When treated with MCF‐7 cell lines, these biosynthesized WGE ZnO NPs have shown a remarkable decline in the cell viability with IC50 value of 44.67 μg/mL. Under the visible light, crystal violet and safranin stains have shown excellent degradation at neutral pH without any reductant, indicating that these green WGE ZnO NPs can serve as a potential photocatalyst in treating wastewater effluents.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Visible Light Driven Photodegradation of Pathological Effluents and Biological Evaluation of Green ZnO Nanoparticles

et al. 2022

View full text Add to dashboard Cite

show abstract

“…After 28 days, 10 rats in each group were randomly selected and numbered as 1 to 10. The rats were subjected to the suspension test, ramp test, and open field test to evaluate their neurobehavioral function [20-22]. For the suspension test, a horizontal glass rod was placed 45 cm away from the table, and the forelegs of the rats were held to the horizontal glass rod (0.5 cm in diameter).…”

Section: Methodsmentioning

confidence: 99%

Clobetasol Attenuates White Matter Injury by Promoting Oligodendrocyte Precursor Cell Differentiation

Yuan

Bai

et al. 2020

Pediatr Neurosurg

View full text Add to dashboard Cite

Introduction: White matter injury (WMI) is the most common brain injury in preterm infants and can result in life-long neurological deficits. The main cause of WMI is damage to the oligodendrocyte precursor cells (OPC) in the brain that results in delayed myelin sheath formation, or the destruction of existing myelin sheaths. OPC undergo highly regulated and strictly timed developmental changes that result in their transformation to mature oligodendrocytes capable of myelin production. Objective: Studies have shown that clobetasol strongly promotes differentiation of OPC into myelin sheaths. Therefore, we hypothesized that clobetasol may be a therapeutic option for the treatment of preterm WMI. Methods: We induced a WMI rat model and observed white matter damage under an optical microscope. Rats subjected to WMI were injected intraperitoneally with clobetasol (2 or 5 mg/kg daily) from day 1 to day 5 in the early treatment groups, or from day 6 to day 10 in the late treatment groups. After 17 days, the rats were sacrificed and the expression of myelin basic protein (MBP) was visualized using immunofluorescence. In addition, we evaluated myelin sheath formation using electron microscopy. The rats were also subjected to the suspension test, ramp test, and open field test to evaluate neurobehavioral functions. Results: A rat model of WMI was successfully induced. It was found that clobetasol significantly induced MBP expression and myelin sheath formation and improved neurobehavioral function in the rats subjected to WMI. Conclusions: Our results indicate that clobetasol attenuates WMI by promoting OPC differentiation, and it may be an effective therapeutic agent for the treatment of preterm WMI.

show abstract

“…Some metallic nanoparticles display special intrinsic analgesic properties, such as zinc oxide, magnesium oxide and magnetite nanoparticles, as verified in mouse models and/or humans. 43 , 44 Several nanoliposomal analgesic formulations have been commercialized, such as Exparel™ for local anesthetic delivery. In addition to the improvement and development of novel nanosized materials as well as manufacturing processes, combination of several nanocarriers and/or other materials provides an alternative strategy to improve therapeutic weaknesses and boost strengths.…”

Section: Current Nano-based Drug Delivery Systems For Local Anestheticsmentioning

confidence: 99%

“…Metal oxide nanoparticles, such as zinc oxide (ZnO) and magnesium oxide (MgO) nanoparticles, have additionally been directly or indirectly examined in the context of local anesthetic delivery. 43 , 44 Jahangiri et al demonstrated that MgO nanoparticles elicit greater analgesic and anti-inflammatory effects in mice via central and peripheral mechanisms compared to conventional MgO. Moreover, MgO nanoparticles potentiated the effects of ketamine, which could be mechanistically linked to the effect of magnesium on ketamine activity as an N-methyl-D-aspartate (NMDA) receptor blocker.…”

Section: Inorganic Nanoparticle-based Drug Delivery Systems For Local...mentioning

confidence: 99%

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

Ma,

Pan,

Lai

et al. 2023

DDDT

View full text Add to dashboard Cite

From a clinical perspective, local anesthetics have rather widespread application in regional blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer treatments. However, a number of disadvantages are associated with traditional local anesthetic agents as well as routine drug delivery administration ways, such as neurotoxicity, short half-time, and non-sustained release, thereby limiting their application in clinical practice. Successful characterization of drug delivery systems (DDSs) for individual local anesthetic agents can support to achieve more efficient drug release and prolonged duration of action with reduced systemic toxicity. Different types of DDSs involving various carriers have been examined, including micromaterials, nanomaterials, and cyclodextrin. Among them, nanotechnology-based delivery approaches have significantly developed in the last decade due to the low systemic toxicity and the greater efficacy of non-conventional local anesthetics. Multiple nanosized materials, including polymeric, lipid (solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions), metallic, inorganic non-metallic, and hybrid nanoparticles, offer a safe, localized, and long-acting solution for pain management and tumor therapy. This review provides a brief synopsis of different nano-based DDSs for local anesthetics with variable sizes and structural morphology, such as nanocapsules and nanospheres. Recent original research utilizing nanotechnology-based delivery systems is particularly discussed, and the progress and strengths of these DDSs are highlighted. A specific focus of this review is the comparison of various nano-based DDSs for local anesthetics, which can offer additional indications for their further improvement. All in all, nano-based DDSs with unique advantages provide a novel direction for the development of safer and more effective local anesthetic formulations.

show abstract

Zinc oxide nanoparticles synthesized from Fraxinus rhynchophylla extract by green route method attenuates the chemical and heat induced neurogenic and inflammatory pain models in mice

Cited by 20 publications

References 46 publications

Visible Light Driven Photodegradation of Pathological Effluents and Biological Evaluation of Green ZnO Nanoparticles

Visible Light Driven Photodegradation of Pathological Effluents and Biological Evaluation of Green ZnO Nanoparticles

Clobetasol Attenuates White Matter Injury by Promoting Oligodendrocyte Precursor Cell Differentiation

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

Contact Info

Product

Resources

About