Zinc Promoted Urea Synthesis Using Carbonyldiimidazole as Carbonyl Source and Its Application for the Synthesis of Cariprazine

Abstract

A convenient method has been developed for symmetrical and un‐symmetrical urea synthesis by using Carbonyldiimidazole (CDI) and recyclable activated zinc metal. This reaction is suitable for all types of amines and gives the desired urea products with good to excellent yield. The developed synthetic approach was employed for the synthesis of the Cariprazine drug.

Use of carbonyldiimidazole as a derivatization agent for the detection of pinacolyl alcohol, a forensic marker for Soman, by EI‐GC–MS and LC‐HRMS in official OPCW proficiency test matrices

“…Another useful result that can be attained after a derivatization reaction is the generation of a product that exhibits sharper peaks relative to the starting, unmodified material as it is in the case of ethanolamines and phosphonic acids [31][32][33][34]. Our work is based on the use of 1,1′-carbonyldiimidazole (CDI), a versatile reagent that reacts with alcohols and amines to yield carbonates [35,36] and ureas, respectively [37][38][39][40], as well as carbamates when both species are used in a sequential fashion [41][42][43]. Its electrophilicity and capacity for activating carboxylic acids as well as alcohols under mild conditions to conduct esterification-amidation [44] and aziridination reaction has been established [45].…”