Zinc

Samman, Samir

doi:10.1111/j.1747-0080.2007.00200.x

Cited by 42 publications

(37 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marginal zinc deficiency has been suggested to influence multiple physiological systems due to the extensive involvement of zinc in numerous structural and biochemical functions of the body (Foster and Samman 2010); a significant proportion of the world's population may be at risk of marginal zinc deficiency (Samman 2007), a condition that contributes substantially to disease burden worldwide (Fischer Walker et al 2009). Despite being redox-inert, zinc can act as a pro-antioxidant and modulate oxidative stress by maintaining cell membrane integrity and regulating the functions of metallothionein (MT), superoxide dismutases, and glutathione (Maret 2003;Oteiza 2012).…”

Section: Introductionmentioning

confidence: 99%

Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

et al. 2015

Self Cite

View full text Add to dashboard Cite

The usefulness of zinc transporter and metallothionein (MT) gene expressions to detect changes in zinc intake remains unclear. This pilot study aimed to determine the effects of zinc supplementation on zinc transporter and MT gene expressions in humans. Healthy adults (n = 39) were randomised to zinc treatment (ZT), receiving 22 mg Zn/day (n = 19), or no treatment (NT) (n = 20). Blood samples were collected on Days 0, 2, 7, 14, and 21. Plasma zinc and serum C-reactive protein concentrations were analysed. Gene expression of zinc transporters and MT in peripheral blood mononuclear cells was analysed using real-time PCR. Using repeated-measures ANOVA, MT-2A gene expression and fold change were found to be higher in the ZT group (P = 0.025 and P = 0.016, respectively) compared to the NT group, specifically at Day 2 (40 ± 18 % increase from baseline, P = 0.011), despite no significant increase in plasma zinc concentration. In a multiple regression model exploring the changes in gene expressions between Days 0 and 21, the change in MT-2A gene expression was correlated with changes in all zinc transporter expressions (r (2) = 0.54, P = 0.029); the change in ZIP1 expression emerged as a univariate predictor (P = 0.003). Dietary zinc intake was predictive of zinc transporter and MT expressions (P = 0.030). Physical activity level was positively correlated with baseline ZIP7 expression (r = 0.36, P = 0.029). The present study shows that MT-2A expression is related to changing expression of zinc transporter genes, specifically ZIP1, in response to zinc supplementation. The current report adds to our understanding of MT in the coordinated nature of cellular zinc homeostasis.

show abstract

Section: Introductionmentioning

confidence: 99%

Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Zinc is an essential trace element with antioxidant activity and functions related to energy metabolism and growth [4]. In addition, zinc has been shown to serve a regulatory role in many signalling pathways, including potentiation of leptin and insulin signalling [5].…”

Section: Introductionmentioning

confidence: 99%

Zinc Status and Risk of Cardiovascular Diseases and Type 2 Diabetes Mellitus—A Systematic Review of Prospective Cohort Studies

2016

Self Cite

View full text Add to dashboard Cite

Zinc is an essential trace element with proposed therapeutic effects in Type 2 diabetes mellitus (DM), however, the associations between zinc status and the prospective risks of cardiovascular diseases (CVD) and Type 2 DM have not been evaluated. The current systematic review aims to determine the relationships between zinc intake or plasma/serum zinc levels and prospective incidence of CVD and Type 2 DM. Fourteen papers describing prospective cohort studies were included, reporting either CVD (n = 91,708) and/or Type 2 DM (n = 334,387) outcomes. Primary analyses from four out of five studies reported no association between zinc intake and CVD events, when adjusted for multiple variables. Higher serum zinc level was associated with lower risk of CVD in three out of five studies; pronounced effects were observed in vulnerable populations, specifically those with Type 2 DM and patients referred to coronary angiography. The limited evidence available suggests no association between zinc status and Type 2 DM risk. Further investigations into the mechanisms of zinc’s action on the pathogenesis of chronic diseases and additional evidence from observational studies are required to establish a recommendation for dietary zinc in relation to the prevention of CVD and Type 2 DM.

show abstract

“…The indicators on satisfaction with social relations and need for relatedness follow the proposal advanced in the accompanying paper within this series on psychological and subjective well-being (Samman 2007). 27 The former tests the subjective satisfaction of a person within different specific domains of life.…”

mentioning

confidence: 99%