Zinc reagents as non-noble catalysts for alkyne activation

Zn-Catalyzed Multicomponent KA2 Coupling: One-Pot Assembly of Propargylamines Bearing Tetrasubstituted Carbon Centers

“…The well-established field of homogeneous zinc catalysis includes the unique chemistry of in situ-generated zinc acetylides, 34,35 which has witnessed a rapid evolution since the seminal discoveries of Carreira and co-workers. 11,35 Catalytic zinc acetylide addition has proven to be an effective strategy for the synthesis of various types of propargylic amines.…”

“…The well-established field of homogeneous zinc catalysis includes the unique chemistry of in situ-generated zinc acetylides, 34,35 which has witnessed a rapid evolution since the seminal discoveries of Carreira and co-workers. 11,35 Catalytic zinc acetylide addition has proven to be an effective strategy for the synthesis of various types of propargylic amines. 6,11,36 Specifically, addition to preformed aldimines in the presence of TMSCl is catalyzed by ZnCl 2 , 37 while Zn(OTf) 2 in toluene is an efficient catalyst for the alkynylation of unactivated, preformed aldimines and ketimines.…”

Zn(II) Chloride Promoted Benzannulation Strategy for One‐Pot Regioselective Synthesis of 6H‐Benzo[c]chromenes

“…In this context, we have found that the ZnCl 2 is an appropriate catalyst for the construction ( 6H ‐benzo[ c ]chromenes) from 4‐(phenylethynyl)‐2 H ‐chromene‐3‐carbaldehydes and terminal alkynes (Scheme ) . Synthetic transformations involving Zinc as catalyst or reagent, are extensively reported in literature due to its easy availability, low toxicity and wide availability in several natural metalloenzymes . Additionally the proposed synthetic strategy was able to demonstrate and produce the analogues of 6 H ‐benzo[ c ]chromene in excellent yields and the starting materials used for obtaining the final products were entirely new (except the model substrate 1 a ), and all the produced derivatives of 6 H ‐benzo[ c ]chromene are novel and these stuctural derivatives were mimics of several natural products and drugs as discussed in figure 1.…”

Metal-supported and -assisted stereoselective cooperative photoredox catalysis

“…Zinc complexes have successfully been used in important catalytic reactions, such as C-H activation, (asymmetric) hydrosilylation and hydroamination, as well as in ring-opening polymerization. [81][82][83] Zinc alkoxides were used in stereoselective polymerization of D,L-lactide 84,85 and β-lactones. 11,85 Tong and coworkers reported on the synthesis of stereoregular poly (α-hydroxy acid) via a photoredox assisted ring opening polymerization of O-carboxyanhydride (OCA) 59, with the cooperative use of [(bpy)Ni(COD)] and zinc alkoxide complexes.…”