Zinc-rich afferents to the rat neocortex: projections to the visual cortex traced with intracerebral selenite injections

Casanovas-Aguilar, C; Reblet, Concepción; Pérez–Clausell, Jeús; Bueno-López, José Luis

doi:10.1016/s0891-0618(98)00035-0

Cited by 42 publications

(28 citation statements)

References 52 publications

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“…Zinc-containing circuits in the mammalian brain arise from a distinct subclass of glutamatergic neurons (Slomianka et al, 1990;Garret and Slomianka, 1992;Land, 1995;Casanovas-Aguilar et al, 1998; for review see Frederickson, 1989;Frederickson et al, 2000). Several studies have used histochemical methods similar to those employed here to chart the location of zinc-sequestering neurons by taking advantage of the fact that zincselenium complexes in axon terminals are translocated, over time, via retrograde axonal transport to neuronal somata (Slomianka et al, 1990).…”

Section: Zinc Circuits Evolve In Concert With Cortical Laminationmentioning

confidence: 99%

“…Several studies have used histochemical methods similar to those employed here to chart the location of zinc-sequestering neurons by taking advantage of the fact that zincselenium complexes in axon terminals are translocated, over time, via retrograde axonal transport to neuronal somata (Slomianka et al, 1990). Significantly, no major cortical afferents have been observed to contain synaptic zinc (Slomianka et al, 1990;Casanovas-Aguilar et al, 1998). This includes neurons in the primary sensory thalamic nuclei, which provide a principal glutamatergic input to cerebral cortex (Kharazia and Weinberg, 1993).…”

Section: Zinc Circuits Evolve In Concert With Cortical Laminationmentioning

confidence: 99%

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Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

Land

Shamalla-Hannah

2002

J of Comparative Neurology

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Distinctive subsets of glutamatergic neurons in cerebral cortex sequester the transition metal zinc within the synaptic vesicles of their axon terminals. In the present study we used histochemical localization of synaptic zinc to investigate normal postnatal development and experience-dependent plasticity of zinc-containing circuits in somatosensory barrel cortex of rats. First, we found that zinc-containing cortical circuits are dynamically reorganized between postnatal day (P) 0 and P28. Whereas most cortical laminae exhibited idiosyncratic increases in zinc histochemical staining with advancing age, lamina IV barrels were darkly reactive early in life and then lost much of their complement of synaptic zinc during postnatal weeks 2-4. Second, we established that sensory experience plays a major role in sculpting the zinc-containing innervation of cortical barrels. Trimming a particular facial whisker arrested the normal postnatal decline in synaptic zinc in the corresponding, deprived barrel. This resulted in more intense zinc staining in deprived barrels compared with adjacent, nondeprived barrels. Notably, the influence of experience on development of zinc circuits was most robust during a critical period extending from about P14, when an effect of whisker trimming first could be observed, through P28, after which time chronic deprivation no longer resulted in heightened levels of synaptic zinc in lamina IV. These findings indicate that sensory input can have a marked influence on development of cortical circuits, including those within lamina IV, throughout the first postnatal month.

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Section: Zinc Circuits Evolve In Concert With Cortical Laminationmentioning

confidence: 99%

Section: Zinc Circuits Evolve In Concert With Cortical Laminationmentioning

confidence: 99%

Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

Land

Shamalla-Hannah

2002

J of Comparative Neurology

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“…Most associative and commissural axons emerge from pyramidal cells sited in layers 2/3 and 5-6, and also from spiny inverted pyramidal cells and other polymorphic cells of layers 5-6 [23,27,28]. The axons of all these cells extend forward to innervate the layer 4 of cortical areas of higher-order hierarchy [23,[27][28][29][30]. This is the so-called associative forward projection [31].…”

Section: Principal Cells Of Intratelencephalic Projection (Inclusive mentioning

confidence: 99%

Projections, Partaken Circuits and Axon Initial Segments of Cortical Principal Neurons

Bueno‐López¹,

Chara²,

Mendizabal-Zubiaga³

et al. 2012

Visual Cortex - Current Status and Perspectives

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“…Both magnesium and zinc modulate the presynaptic transmitters release, the agonist induced response at the level of some receptors (human glycine receptor, P2X receptor) [7,8] and also several ion-gated ion channels [9]. Zinc-containing neurons are mainly located in the cerebral cortex and in the amygdala [10]. Zinc-containing fibers connect these regions to brain areas involved in addiction (limbic system, striatum and others) [1].…”

Section: Introductionmentioning

confidence: 99%

“…Both cations have selective transporters in brain [14,15]. Both magnesium and zinc modulate the presynaptic transmitters release, the agonist induced response at the level of some receptors [16] and also several ion-gated ion channels [10]. Magnesium is used in the treatment of neurosis, in eclamptic and pre-eclamptic states, and also in traumatic and ischemic brain injury.…”

Section: Introductionmentioning

confidence: 99%

Magnesium and Zinc Involvement in Tobacco Addiction

Nechifor¹

2012

J Addict Res Ther

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This paper is a review regarding magnesium and zinc influence on smoking and tobacco addiction. Magnesium and zinc are two very important bivalent cations involved in different functions of central nervous system. There are different mechanisms by which magnesium can decrease the nicotine addiction. Magnesium decrease the dopamine release and the NMDA receptor stimulation by glutamate (two essential steps in the devolopment of nicotine addiction). This cation also inhibits the synthesis of substance P and nitric oxide, others important neurotransmiters involved in addiction. Magnesium may decrease the nicotine effect on GABA synthesis and could reduce also NPY involvement in nicotine addiction. Zinc also reduces the glutamatergic brain systems activity and modulates the nicotinic receptors activity from brain. The hypomagnesemia favorises the development of tobacco addiction .The magnesium treatment can be beneficial for reducing the smoking and nicotine addiction in heavy smokers. By increasing the magnesium concentration we can moderately improve the stimulation of the reward system and can reduce the needs of stimulation by nicotine or by others addictive substances. The treatment of intracellular and plasma magnesium deficit could be way to minimize the development of tobacco smoking and nicotine addiction.

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Zinc-rich afferents to the rat neocortex: projections to the visual cortex traced with intracerebral selenite injections

Cited by 42 publications

References 52 publications

Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

Experience‐dependent plasticity of zinc‐containing cortical circuits during a critical period of postnatal development

Projections, Partaken Circuits and Axon Initial Segments of Cortical Principal Neurons

Magnesium and Zinc Involvement in Tobacco Addiction

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