Zinc-Selenium Interaction in the Rat

Chmielnicka, Jadwiga; Zaręba, Grażyna; Witasik, M.; Brzeźnicka, E A

doi:10.1007/978-1-4612-4606-0_21

Cited by 7 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results from the present study showed that Zn markedly elevated Se concentrations in plasma, erythrocytes, muscle, heart, and liver, and Se and Zn had a significant synergic interaction on plasma Se concentration. This observation was supported by the results of LU and Combs (19) and Chmielnicka et al (20), who showed that excess Zn in purified diet slightly enhanced by 14-31% the concen tration of Se in chick liver compared with normal control (19) and that combined administration of Zn and Se increased Se retention in brain, spleen, kidneys, blood, lungs, and heart of rats (20). However, the results of the present study were different from those obtained by Naganuma et al (6), who showed that coad EFFECTS OF Zn AND Cd ON GSH-Px ACTIVITY AND Se CONCENTRATION 35 ministration of Zn and Se tended to decrease concentrations of Se in plasma, erythrocytes, lung, brain, kidney, spleen, and testis in mice; especially in heart and liver a significant decrease was observed.…”

Section: Discussionsupporting

confidence: 53%

Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite.

Yin

Sato

Hosokawa

et al. 1991

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 53%

Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite.

Yin

Sato

Hosokawa

et al. 1991

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

“…There was probably an interaction between selenium (Se − ) and copper or zinc (Cu ++ or Zn ++ ). For example, in rat, zinc induced a decrease in the excretion of selenium in urine [31], and interaction at the molecular level was described in human [32]. However, in other cases, no interaction was observed [33].…”

Section: Relationships With Other Parametersmentioning

confidence: 94%

Effect of Different Selenium Supplementation Levels on Selenium Status in Camel

Seboussi

Faye

Alhadrami

et al. 2008

Biol Trace Elem Res

View full text Add to dashboard Cite

Twelve female camels divided into three groups received, after a 2-week adaptation period, an oral Se supplementation (0, 2, and 4 mg, respectively) under sodium selenite form for 3 months. Feed intake was assessed daily, blood samples and body weight were taken on a weekly basis, and feces and urine samples were collected every 2 weeks up to 1 month after the end of the supplementation period. The Se concentration in serum was increased significantly in supplemented groups. The maximum level was observed in the period of supplementation in the camel receiving 4 mg (492.5 ng/mL), which was fourfold higher than the value at the beginning of the trial (126 to 138.5 ng/mL according to the groups). The selenium concentration increased significantly in urine and feces but to a lesser extent. A similar trend was observed with glutathione-peroxidase (GSH-Px) values varying between 8.4 and 96.5 IU/g Hb. However, no difference occurred between the two groups receiving 2 or 4 mg Se at the supplementation period. Vitamin E (mean 1.13 +/- 0.61 microg/mL with range 0.27-3.09) did not change significantly. Significant correlations were reported between serum Se, GSH-Px, fecal, and urinary excretion or concentration.

show abstract

“…Interaction between selenium, copper, or zinc was described for example in rat where zinc induced a decrease in the urinary excretion of selenium [37]. However, in other cases, no interaction was observed [38].…”

Section: Relationships With Other Parametersmentioning

confidence: 96%

Selenium Distribution in Camel Blood and Organs After Different Level of Dietary Selenium Supplementation

Seboussi

Faye

Alhadrami

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

Eight young female camels shared in four groups of two 2 years received a basal diet enriched respectively with 0, 2, 4, and 8 mg selenium under sodium selenite form for 64 days. Feed intake was assessed daily; blood samples were taken on weekly basis. One camel from each group was killed at the end of the experiment. Se concentration in serum was increased significantly in the supplemented groups with an average of 176.3 +/- 18.0 ng/mL in the control group, 382.7 +/- 107.6 in the group receiving 2 mg Se, 519.8 +/- 168.4 in the group receiving 4 mg Se, and 533.4 +/- 158.6 in the group receiving 8 mg Se daily. For glutathione peroxidase (GSH-Px) activity, the control group (51.0 IU/g Hb) and the group receiving 2 mg (50.5 IU/g Hb) were significantly different than groups receiving 4 and 8 mg (respectively, 65.9 and 76.1 IU/g Hb). No significant variation occurred for vitamin E (mean, 0.56 +/- 0.23 ng/mL). Significant correlation between serum Se and GSH-Px was reported. Kidney was the richest organ in selenium followed by lung, spleen, and liver, but the increase in supplemented groups was more marked in liver and kidney. The hair seemed to be the best indicator of selenium intake in camel.

show abstract

Zinc-Selenium Interaction in the Rat

Cited by 7 publications

References 16 publications

Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite.

Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite.

Effect of Different Selenium Supplementation Levels on Selenium Status in Camel

Selenium Distribution in Camel Blood and Organs After Different Level of Dietary Selenium Supplementation

Contact Info

Product

Resources

About