Zinc Status and Febrile Seizures: Results from a Cross-sectional Study

Arul, Janani; Kommu, Peter Prasanth Kumar; Kasinathan, Ananthanarayanan; Ray, Lopamudhra; Krishnan, Lalitha

doi:10.1055/s-0040-1715992

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…There are also several blood analyses. C-reactive protein level, blood glucose level, serum sodium level, serum zinc level and vitamin D were indicated significant association with recurrent FSs (Hugen et al, 1995;Kiviranta and Airaksinen, 1995;Lee and Kim, 2012;Waqar Rabbani et al, 2013;Arul et al, 2020;Bhat et al, 2020;Kubota et al, 2021;Miyagi et al, 2022). To be noted, there is evidence from meta-analysis and cross-sectional studies that hyponatremia and hypozinc may be strongly associated with the recurrence of FSs.…”

Section: Recurrence Of Fssmentioning

confidence: 99%

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

You

Chen

2023

Front. Cell Dev. Biol.

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Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during a fever. FSs are one of the commonest presentations in young children, occurring in up to 4% of children between the ages of about 6 months and 5 years old. FSs not only endanger children’s health, cause panic and anxiety to families, but also have many adverse consequences. Both clinical and animal studies show that FSs have detrimental effects on neurodevelopment, that cause attention deficit hyperactivity disorder (ADHD), increased susceptibility to epilepsy, hippocampal sclerosis and cognitive decline during adulthood. However, the mechanisms of FSs in developmental abnormalities and disease occurrence during adulthood have not been determined. This article provides an overview of the association of FSs with neurodevelopmental outcomes, outlining both the underlying mechanisms and the possible appropriate clinical biomarkers, from histological changes to cellular molecular mechanisms. The hippocampus is the brain region most significantly altered after FSs, but the motor cortex and subcortical white matter may also be involved in the development disorders induced by FSs. The occurrence of multiple diseases after FSs may share common mechanisms, and the long-term role of inflammation and γ-aminobutyric acid (GABA) system are currently well studied.

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Section: Recurrence Of Fssmentioning

confidence: 99%

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

You

Chen

2023

Front. Cell Dev. Biol.

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“…Zinc deficiency has been indicated by various studies in connection with an increased risk for seizures [ 114 , 115 ], studied also extensively in children [ 116 , 117 ]. Knockout of the zinc receptor ZnT3 results in a lack of zinc in the synaptic vesicles and consequently has been shown to result in seizures and neuronal damage [ 97 ].…”

Section: Physiological Functions Of Gpr39mentioning

confidence: 99%

The Zinc-Sensing Receptor GPR39 in Physiology and as a Pharmacological Target

Laitakari

Liu

Frimurer

et al. 2021

IJMS

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The G-protein coupled receptor GPR39 is abundantly expressed in various tissues and can be activated by changes in extracellular Zn2+ in physiological concentrations. Previously, genetically modified rodent models have been able to shed some light on the physiological functions of GPR39, and more recently the utilization of novel synthetic agonists has led to the unraveling of several new functions in the variety of tissues GPR39 is expressed. Indeed, GPR39 seems to be involved in many important metabolic and endocrine functions, but also to play a part in inflammation, cardiovascular diseases, saliva secretion, bone formation, male fertility, addictive and depression disorders and cancer. These new discoveries offer opportunities for the development of novel therapeutic approaches against many diseases where efficient therapeutics are still lacking. This review focuses on Zn2+ as an endogenous ligand as well as on the novel synthetic agonists of GPR39, placing special emphasis on the recently discovered physiological functions and discusses their pharmacological potential.

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“…This conclusion is based on the fact that neuronal excitement has a significant impact on zinc concentration [ 18 ]. It is worth noting that knocking down zinc transporters has been proven to improve susceptibility to kainate-induced seizures in studies [ 19 ], emphasizing the importance of zinc during epileptic episodes Animal studies have shown that zinc has neuromodulatory effects in epileptogenesis [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Growth-Associated Protein-43 and Neurotrophin-3 in Childhood Epilepsy and Their Relation to Zinc Levels

Bakri

Hassan

Ahmed

et al. 2022

Biol Trace Elem Res

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Background Epilepsy is one of the most common neurological disorders, and it places a significant economic strain on the healthcare system around the world. Although the exact mechanism of epilepsy has yet to be illustrated, various pathogenic cascades involving neurotransmitters and trace elements have been reported. We aimed to investigate the serum levels of growth-associated protein-43 (GAP-43) and neurotrophin-3 (NT-3) among cohort of Egyptian children with epilepsy and correlate these biomarkers with their zinc levels. Methods This case–control study included 50 pediatric patients with epilepsy who were comparable with 50 controls. Neurological assessment and electroencephalogram (EEG) were done to all included children. Biochemical measurements of serum GAP-43 and NT-3 using enzyme linked immunosorbent assays (ELISA), and total antioxidant capacity (TAC) and zinc using colorimetric assays, were performed to all participants. Results There was significantly frequent positive parental consanguinity among cases with significantly frequent generalized onset seizures (94%) than simple partial seizure (6%). There were significantly lower serum GAP-43 and zinc levels with significantly higher TAC among cases vs. the controls, p˂0.05 for all. There was no significant difference in the serum levels of NT-3 among epileptic children vs. the controls, p = 0.269. Serum Zn was positively correlated with GAP-43 level among epileptic children (r = 0.381, p = 0.006). Serum GAP-43 in diagnosing childhood epilepsy at cut-off point ≤ 0.6 ng/mL showed 78% sensitivity, 62% specificity, positive predictive value (PPV) = 50.6%, negative predictive value (NPP) = 84.9% with AUC = 0.574. Conclusion GAP-43 can be considered a sensitive good negative biomarker in childhood epilepsy which correlated positively with the zinc status.

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Zinc Status and Febrile Seizures: Results from a Cross-sectional Study

Cited by 8 publications

References 11 publications

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

The Zinc-Sensing Receptor GPR39 in Physiology and as a Pharmacological Target

Serum Levels of Growth-Associated Protein-43 and Neurotrophin-3 in Childhood Epilepsy and Their Relation to Zinc Levels

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