2024
DOI: 10.1002/asia.202400257
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Zinc‐Substituted Hemoglobin–Albumin Cluster as a Porphyrin‐Carrier for Enhanced Photodynamic Therapy

Taiga Yamada,
Maho Katsumi,
Kota Ishii
et al.

Abstract: Apohemoprotein is focused on the field of theranostics, serving as a porphyrin carrier. Hemoglobin (Hb) consists of α2β2 tetramer with iron(II)‐protoporphyrin IX (heme) bound to each globin. However, heme‐removed Hb (apoHb) causes dissociation at αβ interfaces and aggregation under physiological conditions. We synthesized a stable apoHb derivative comprising intramolecular‐crosslinked apoHb (apoXHb) and human serum albumin (HSA), apoXHb‐HSA3. ApoXHb‐HSA3 engendered no aggregates in the physiological solutions.… Show more

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