Zinc sulfate improved the unbalanced T cell profiles in Der p‐allergic asthma: An ex vivo study

Tsai, Yu Lin; Ko, Wang‐Sheng; Hsiao, Jung-Lung; Pan, S. K.; Chiou, Ya‐Ling

doi:10.1111/crj.12563

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…Depleted zinc levels also affect immune responses in the nasal mucosa and have been shown to promote pro-inflammatory cytokine production in HNECs (12). Also, significant negative correlations between tissue zinc levels and eosinophil infiltration into the nasal mucosa of CRS patients have been demonstrated, in line with previous findings of Th2 polarisation and eosinophilia in the context of zinc deficiency (4)(5)(6). Tissue zinc levels are also correlated with collagen abundance in nasal mucosa and zinc depleted-fibroblasts synthesized less collagen compared to control cells.…”

Section: Discussionsupporting

confidence: 86%

“…Zinc is an essential trace element required for the normal functioning of many organ systems including the immune system. Zinc deficiency decreases the function of Th1 cells, but not that of Th2 cells and is associated with Th2 polarisation and eosinophilic inflammation (4)(5)(6). Zinc depleted diet has been shown to promote eosinophil infiltration into the lung in mice (7).…”

Section: Introductionmentioning

confidence: 99%

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Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa

et al. 2021

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa

et al. 2021

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“…Among them, IL-4 can promote B cell maturation and convert IgG into IgE, and promote the differentiation of T cells into TH2 cells, thus leading to an ameliorate in IgE level. However, zinc supplementation may alleviate the production of inflammatory cytokines and restore TH1/TH2 cell subpopulations through inhibition of related inflammatory signaling pathways [ 25 , 26 ].…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF‐KB Signaling Pathway

Shi

Shen

Long

et al. 2022

Contrast Media & Molecular Imaging

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Allergic rhinitis is one of the common chronic inflammatory diseases of the nasal mucosa. In order to investigate the effect of zinc on ovalbumin induced allergic rhinitis in BALB/C male mice based on NF-KB signaling pathway, thirty BALB/C male mice are randomly divided into three groups: control group, ovalbumin induced allergic rhinitis asthma group and zinc intervention group. The experimental results show that Zinc supplementation in allergic asthma mice with allergic rhinitis correct the immune response of TH2 cells by inhibiting THE NF-KB signaling pathway, reduce the infiltration of inflammatory cells into lung nasal tissue, and reduce airway co-hyperreactivity to improve the clinical symptoms of asthma and play an immune protective role.

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“…In cultured human PBMCs (peripheral blood mononuclear cells), zinc deficiency increases Th17 differentiation [121]. On the other hand, the zinc supplement in the cell culture of allergen-stimulated PBMCs alters the Th1/Th2 ratio and decreases the proportion of Th17 [122]. Zinc supplementation also enhances Treg differentiation either in allergen-stimulated PBMCs from atopic patients [37] or in TGF-β treated PBMCs and mixed lymphocyte cultures [36].…”

Section: Vitamins and Mineralsmentioning

confidence: 99%

The Role of Diet and Nutrition in Allergic Diseases

Zhang

2023

Nutrients

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Allergic diseases are a set of chronic inflammatory disorders of lung, skin, and nose epithelium characterized by aberrant IgE and Th2 cytokine-mediated immune responses to exposed allergens. The prevalence of allergic diseases, including asthma, allergic rhinitis, and atopic dermatitis, has increased dramatically worldwide in the past several decades. Evidence suggests that diet and nutrition play a key role in the development and severity of allergic diseases. Dietary components can differentially regulate allergic inflammation pathways through host and gut microbiota-derived metabolites, therefore influencing allergy outcomes in positive or negative ways. A broad range of nutrients and dietary components (vitamins A, D, and E, minerals Zn, Iron, and Se, dietary fiber, fatty acids, and phytochemicals) are found to be effective in the prevention or treatment of allergic diseases through the suppression of type 2 inflammation. This paper aims to review recent advances in the role of diet and nutrition in the etiology of allergies, nutritional regulation of allergic inflammation, and clinical findings about nutrient supplementation in treating allergic diseases. The current literature suggests the potential efficacy of plant-based diets in reducing allergic symptoms. Further clinical trials are warranted to examine the potential beneficial effects of plant-based diets and anti-allergic nutrients in the prevention and management of allergic diseases.

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Zinc sulfate improved the unbalanced T cell profiles in Der p‐allergic asthma: An ex vivo study

Abstract: Zinc ameliorates the imbalance in T cell profiles and could be a potential adjuvant therapy for Der p-induced allergic hypersensitivity.

Cited by 11 publications

References 38 publications

Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa

Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa

[Retracted] Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF‐KB Signaling Pathway

The Role of Diet and Nutrition in Allergic Diseases

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