Zinc Sulfate in Acne Vulgaris

Weimar, Virginia M.; Puhl, Susan C.; Smith, Wade H.; tenBroeke, James E.

doi:10.1001/archderm.1978.01640240018005

Cited by 46 publications

(7 citation statements)

References 8 publications

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“…In further placebo-controlled investigations zinc salts were more effective than the placebo [351][352][353][354][355]; in two studies no difference was found to the placebo [356,357]. In a randomized, doubleblind controlled comparative study between zinc gluconate (equivalent to 30 mg elementary zinc /d) and minocycline (100 mg /d), after a treatment period of three months zinc proved to be effective but less effective than minocycline (n=332) [358].…”

Section: Effectivenessmentioning

confidence: 99%

S2k – Guideline on the Therapy of Acne

Nast

Bayerl

Borelli

et al. 2010

J Deutsche Derma Gesell

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Section: Effectivenessmentioning

confidence: 99%

S2k – Guideline on the Therapy of Acne

Nast

Bayerl

Borelli

et al. 2010

J Deutsche Derma Gesell

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“…Of these, 2489 records were excluded based on title and abstract screening. Among 93 full-text articles assessed for eligibility, 42 articles (3346 participants) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] met the inclusion criteria and were included in the review (Figure). Of the included studies, 27 (64.3%) 6, 7, 9, 12, 13, 17, 19-21, 23, 24, 27, 29, 30, 32, 36-40, 42-47 were of poor quality, 11 (26.2%) 8,10,11,[14][15][16]18,22,28,31,34,35 were of fair quality, and 4 (9.5%) 25,26,33,41 were of good quality (Table 1, Table 2, and Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 2489 records were excluded based on title and abstract screening. Among 93 full-text articles assessed for eligibility, 42 articles (3346 participants) met the inclusion criteria and were included in the review (Figure). Of the included studies, 27 (64.3%) were of poor quality, 11 (26.2%) were of fair quality, and 4 (9.5%) were of good quality (Table 1, Table 2, and Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…Zinc is thought to target acne through decreasing sebum production and anti-inflammatory mediators as well as through antibacterial effects on Cutibacterium acnes, though its exact mechanisms are not fully understood. 48 Of the 15 articles evaluating zinc in the treatment of acne, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] 4 of 6 studies (66.7%) of fair quality 10,11,14,16 and 4 of 9 studies (44.4%) of poor quality 6,9,13,17 found zinc to be efficacious (Tables 1-3 and eTable in the Supplement).…”

Section: Zincmentioning

confidence: 99%

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Safety and Effectiveness of Oral Nutraceuticals for Treating Acne

Shields,

Ly,

Wafae

et al. 2023

JAMA Dermatol

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ImportancePatients with acne are interested in nutraceuticals as a potential treatment option. However, there is uncertainty regarding the efficacy and safety of these products.ObjectiveTo evaluate the evidence for oral nutraceuticals in the treatment of acne.Evidence ReviewThe PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases were searched from inception through January 30, 2023, to identify randomized clinical trials evaluating oral nutraceutical interventions (ie, vitamins and minerals, botanical extracts, prebiotics, and probiotics) in individuals with acne. Clinician-reported outcomes (eg, investigator global assessment, lesion counts), patient-reported outcomes (eg, quality of life), and adverse events were extracted from the included studies. The quality of evidence was assessed using the Cochrane Risk of Bias checklist tool for randomized clinical trials. Based on the Risk of Bias tool, articles were converted to Agency for Healthcare Research and Quality standards of good, fair, or poor quality.FindingsA total of 2582 abstracts were identified in the database search, 42 of which met inclusion criteria (a total of 3346 participants). Studies of fair or good quality showed the potential benefit of vitamins B5 and D, botanical extracts (green tea), probiotics, and ω-3 fatty acids in the treatment of acne. These interventions were most frequently associated with decreased lesion counts or improved investigator global assessment scores. Adverse effects were rare for most of the therapies evaluated, but gastrointestinal tract adverse effects were reported for zinc therapy.Conclusions and RelevanceThis systematic review suggests a possible role for nutraceutical supplements in the treatment of acne. Physicians should be prepared to discuss the evidence regarding the potential role of nutraceuticals with patients. Many studies were of small size, and future research should focus on larger randomized clinical trials to assess the utility of nutraceuticals in the treatment of acne.

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“…In einer randomisierten doppelblind kontrollierten Studie bei entzündlicher Akne war Zink‐Glukonat (entsprechend 30 mg elementarem Zink täglich) besser als Plazebo in der Reduktion entzündlicher Veränderungen [8] (Empfehlungsgrad B, Evidenzstufe 2b; n = 66). In weiteren Plazebo‐kontrollierten Untersuchungen erwiesen sich Zinksalze in fünf Studien als effektiver als Plazebo [9, 10, 11, 12, 13], in zwei Studien fand sich kein Unterschied zu Plazebo [14, 15]. In einer randomisierten doppelblind kontrollierten Vergleichsstudie zwischen Zink‐Glukonat (entsprechend 30 mg elementarem Zink täglich) und Minocyclin (100 mg täglich) erwies sich Zink nach einem Behandlungszeitraum von drei Monaten als wirksam, jedoch weniger wirksam als Minocyclin [16] (Empfehlungsgrad B, Evidenzstufe 1b; n = 332).…”

Section: Zinkunclassified

Ergänzende Verfahren in der Aknetherapie

Degitz

Plewig

2005

J Deutsche Derma Gesell

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The mainstays of modern acne therapy include comedolytic, antimicrobial, and anti-inflammatory substances, as well as antiandrogens. Additionally, traditional or newly developed therapeutic approaches may be considered, including pharmacologic (dapsone, zinc) and physical measures (phototherapy, photodynamic therapy, comedone extraction, abrasives). This article reviews such adjunctive therapies with regard to efficacy and their roles in acne therapy.

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Zinc Sulfate in Acne Vulgaris

Cited by 46 publications

References 8 publications

S2k – Guideline on the Therapy of Acne

S2k – Guideline on the Therapy of Acne

Safety and Effectiveness of Oral Nutraceuticals for Treating Acne

Ergänzende Verfahren in der Aknetherapie

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