Zinc sulfate therapy for infertile male with or without varicocelectomy

Takihara, Hiroshi; Cosentino, Marco; Cockett, Abraham T.K.

doi:10.1016/0090-4295(87)90111-7

Cited by 34 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human sperm mannose receptor expression is modulated by the level of Zn 2+ in seminal plasma. This helps explain why spermatozoa from infertile men with varicocele, who commonly have abnormally low levels of seminal plasma Zn 2+ ( Takihara et al ., 1987 ; Ando et al ., 1989 , 1990; Benoff, 1997b; Benoff et al ., 19 97a), display reduced mannose receptor levels ( Benoff, 1997b; Benoff et al ., 19 97a) and why oral Zn 2+ supplementation apparently increases the pregnancy rates of some varicocele patients ( Takihara et al ., 1987 ).…”

Section: Discussionmentioning

confidence: 99%

Metal ions and human sperm mannose receptors

et al. 2000

View full text Add to dashboard Cite

Zinc and lead concentrations were measured in seminal plasma from fertile donors, infertile men with varicocoele and men undergoing work-ups for in vitro fertilization. Ejaculated spermatozoa from these subjects were incubated in vitro with various metal ions and/or dibromoethane and dibromochloropropane. Mannose receptor expression was correlated with metal and toxicant levels. Sperm distributions of potassium channels were compared with lead ions and calcium channels with zinc ions. Mannose receptor expression by capacitated spermatozoa increased linearly with seminal plasma zinc levels, and correlated inversely with lead levels. Cobalt had no effect on mannose receptor expression, but nickel had a concentration-dependent biphasic effect. Mannose receptor expression was not affected by dibromoethane and dibromochloropropane if the cholesterol content of the sperm membrane was high, but mannose receptor expression was decreased in low cholesterol spermatozoa by exposures below estimated permissive exposure limits. Potassium channels and lead ions co-localized over the entire head of human spermatozoa, while both calcium channels and zinc ions were confined to the equatorial segment of the head. Mannose receptor expression on the external surface of the human sperm plasma membrane is a biomarker for the effects of transition and heavy metals and organic toxicants on sperm fertility potential.

show abstract

Section: Discussionmentioning

confidence: 99%

Metal ions and human sperm mannose receptors

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Zn 2+ deficiency has been described for several diseases, including sickle cell anemia, malnutrition, cancer, alcoholism, uremia, and various infections. For PLWH, serum levels of Zn 2+ decreased with disease progression [108][109][110][111][112][113][114][115][116][117] and clinical symptom similarities exist between HIV-1/AIDS and Zn 2+ deficiency [113,114,118]. Further, higher mortality rates occurred in PLWH with low levels of Zn 2+ [119][120][121][122], and Zn 2+ deficiency and increased levels of tumor necrosis factor-α (TNF-α) were found in people with AIDS [123][124][125].…”

Section: Zinc (Zn 2+ )mentioning

confidence: 98%

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

Khan

Chen

Geiger

2020

Viruses

View full text Add to dashboard Cite

Divalent cations are essential for life and are fundamentally important coordinators of cellular metabolism, cell growth, host-pathogen interactions, and cell death. Specifically, for human immunodeficiency virus type-1 (HIV-1), divalent cations are required for interactions between viral and host factors that govern HIV-1 replication and pathogenicity. Homeostatic regulation of divalent cations’ levels and actions appear to change as HIV-1 infection progresses and as changes occur between HIV-1 and the host. In people living with HIV-1, dietary supplementation with divalent cations may increase HIV-1 replication, whereas cation chelation may suppress HIV-1 replication and decrease disease progression. Here, we review literature on the roles of zinc (Zn2+), iron (Fe2+), manganese (Mn2+), magnesium (Mg2+), selenium (Se2+), and copper (Cu2+) in HIV-1 replication and pathogenicity, as well as evidence that divalent cation levels and actions may be targeted therapeutically in people living with HIV-1.

show abstract

“…Zinc is a powerful antioxidant (347). Abnormally low seminal plasma zinc levels occur in many cases with varicoceles (114, [348][349][350]. Testicular zinc is also lowered in varicocele patients (S. Benoff, J.L.…”

Section: Supplementary Zincmentioning

confidence: 99%

“…Hurley, unpublished observations). Some men who remain infertile post-varicocelectomy have low seminal plasma zinc levels after varicocele correction (348)(349)(350). Prior reports (e.g., 348), including one from our group (351), suggest that oral zinc supplementation in these cases improves semen quality and pregnancy rates.…”

Section: Supplementary Zincmentioning

confidence: 99%