Zinc supplement reverses short-term memory deficit in sodium benzoate-induced neurotoxicity in male Wistar rats by enhancing anti-oxidative capacity via Nrf 2 up-regulation

Akintoye, Olabode Oluwadare; Ajibare, Ayodeji Johnson; Folawiyo, A.M; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Asuqu, A.; Owolabi, G.A; Babalola, T.K

doi:10.1016/j.bbr.2022.114163

Cited by 8 publications

(2 citation statements)

References 34 publications

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“…It could promote body health and microbiome balance (Yusof et al, 2023). Zinc supplement improves memory deficit by enhancing anti-oxidative capacity via Nrf 2 upregulation in male Wistar rats (Akintoye et al, 2023). Shao et al (2023) found that dietary zinc supplementation at the level of 120 mg/kg for breeding pigeons improves the carcass traits and breast muscle yield of squabs through regulating antioxidant capacity in liver and breast muscle and myogenic regulatory factor expression.…”

Section: Zinc Supplementationmentioning

confidence: 99%

The Potential Impacts of Antioxidant Micronutrients on Productive and Reproductive Performances of Mammalian Species during Stressful Conditions

Mohammed,

Al-Suwaiegh,

Al-Gherair

et al. 2024

IJAR

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Background: The antioxidant micronutrients supplementation to mammalian species during stressful condition have gained great attention of nutritionists to alleviate stressful peri parturient factors, which negatively effect on productive and reproductive performances in subtropics. Methods: The antioxidant micronutrients given to mammalian species refer to minerals (copper, zinc and selenium) and vitamins (vitamins A, C and E). The balanced diet needs an adequate amount of antioxidant micronutrients during stressful conditions for mammalian species. Result: The antioxidant micronutrients are played pivotal roles for body functions especially during transitional period in ruminants. They are given to improve quality of feed, cell functions, carbohydrates, protein and metabolism. Changes in animals’ production, reproduction and therapeutic performances have been confirmed over antioxidant micronutrients supplementations. The antioxidant micronutrients change feed intake, nutrient digestibility, rumen fermentation and energy production. Such increases in feed digestibility and growth performance resulted in improvement of oocyte, embryo and fetus qualities. In addition, blood cells and plasma biochemistry, immunity and therapeutic performances were altered due to antioxidant micronutrient supplementation. Hence, the review article was designed to collect, consolidate and discuss the effects of antioxidant micronutrient supplementation on productive, reproductive and therapeutic performances on ruminant species during transitional period in subtropics.

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Section: Zinc Supplementationmentioning

confidence: 99%

The Potential Impacts of Antioxidant Micronutrients on Productive and Reproductive Performances of Mammalian Species during Stressful Conditions

Mohammed,

Al-Suwaiegh,

Al-Gherair

et al. 2024

IJAR

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“…Recently, the relationship between increased body mass index (BMI) and waist circumference (WC) with cognitive decline and dementia in the elderly was described [19,20]. In addition, Zn supplementation was able to reverse short-term memory deficits in rats [21] and increase antioxidant and anti-inflammatory capacity in both animals and humans [21,22]. However, the effects of Zn on cognition in clinical studies are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

de Vargas,

Jantsch,

Fontoura

et al. 2023

Nutrients

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Obesity has been linked to cognitive decline and adverse effects on brain health. Zinc (Zn) is a mineral with important metabolic functions that can modulate obesity-related neurological impairment. Thus, the present study aimed to evaluate the effects of 12 weeks of Zn supplementation on the inflammatory profile, cognitive function, and mood of overweight or obese women through a double-blind, placebo-controlled study. The study included 42 women aged between 40 and 60, randomly divided into two groups: Zn supplementation (30 mg/day) or placebo for 12 weeks. Data regarding sociodemographic, anthropometric, dietary, and physical activity were collected. Mini-mental state examination (MMSE), verbal fluency test, clock drawing test, and Stroop test were performed. Anxiety and depression symptoms were assessed using the Beck anxiety inventory and the BDI-II, respectively. Saliva samples were collected to evaluate IL-1β, IL-6, TNF-α, insulin, nitrite, and Zn levels. Of the 42 participants (mean age 49.58 ± 6.46 years), 32 were included in the study analyses. Changes in body weight and macronutrient consumption were not different between placebo and Zn supplementation groups. Cognitive scores on the MMSE and Stroop tests were higher in the Zn supplementation group than in the placebo group. Salivary levels of IL-1b and Zn increased in the Zn group compared to placebo. There was no significant change in the adjusted means of the BDI-II and BECK scores between the zinc vs. placebo groups. Twelve weeks of Zn supplementation was able to partially improve the cognitive scores assessed in overweight or obese women, regardless of weight loss. These findings suggest that Zn supplementation can be considered an adjunct strategy to enhance cognitive health in overweight or obese women.

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Zinc Ameliorates Tripterygium Glycosides–Induced Reproductive Impairment in Male Rats by Regulating Zinc Homeostasis and Expression of Oxidative Stress–Related Genes

Ma,

Tan,

et al. 2023

Biol Trace Elem Res

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Zinc supplement reverses short-term memory deficit in sodium benzoate-induced neurotoxicity in male Wistar rats by enhancing anti-oxidative capacity via Nrf 2 up-regulation

Cited by 8 publications

References 34 publications

The Potential Impacts of Antioxidant Micronutrients on Productive and Reproductive Performances of Mammalian Species during Stressful Conditions

The Potential Impacts of Antioxidant Micronutrients on Productive and Reproductive Performances of Mammalian Species during Stressful Conditions

Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

Zinc Ameliorates Tripterygium Glycosides–Induced Reproductive Impairment in Male Rats by Regulating Zinc Homeostasis and Expression of Oxidative Stress–Related Genes

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