Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation

Mousaviyan, Ronak; Davoodian, Nahid; Alizadeh, Faezeh; Ghasemi-Kasman, Maryam; Mousavi, Seyed Abdollah; Shaerzadeh, Fatemeh; Kazemi, Haniyeh

doi:10.1007/s12011-020-02553-6

Cited by 16 publications

(10 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…REC.1397.276). To minimize the number and the suffering of animals based on the Three Rs principle, we shared the treated animals in two other published articles ( Alizadeh et al, 2020 ; Mousaviyan et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Immunofluorescence staining was carried out, as described previously ( Mousaviyan et al, 2021 ). After anesthetization with ketamine/xylazine (100 mg/kg - 10 mg/kg), animals (n=4/group) were transcardially perfused with Phosphate-Buffered Saline (PBS) and 4% paraformaldehyde (PFA).…”

Section: Methodsmentioning

confidence: 99%

“…All experimental procedures were based on the National Institutes of Health guide for the care and use of laboratory animals and approved by the ethical committee of HUMS (IR.HUMS.REC.1397.276). To minimize the number and suffering of animals based on the Three Rs principle, we shared the treated animals in two other published articles (Alizadeh et al, 2020;Mousaviyan et al, 2021).…”

Section: Animalmentioning

confidence: 99%

See 2 more Smart Citations

Prenatal Zinc Supplementation Ameliorates Hippocampal Astrocytes Activation and Inflammatory Cytokines Expression Induced by Lipopolysaccharide in a Rat Model of Maternal Immune Activation

Savareh

Davoodian

Mousaviyan

et al. 2022

BCN

Self Cite

View full text Add to dashboard Cite

Objective: There is evidence that gestational exposure to lipopolysaccharide (LPS) results in fetal zinc deficiency, and eventually neurodevelopmental abnormalities. In this study, we utilized a rat model of maternal immune activation (MIA) to investigate the possible neuroprotective effect of zinc supplementation throughout pregnancy on hippocampal astrocytes activation as well as inflammatory cytokines expression in adult offspring. Methods: Pregnant rats received intraperitoneal injections of either LPS (0.5 mg/kg) or saline at gestational day (GD) 15 and 16 and orally gavaged with zinc sulfate (30 mg/kg) throughout pregnancy. Astrocyte density and histological assessment were evaluated in the hippocampus of adult offspring at postnatal day (PND) 60-62. Also, the mRNA levels of IL-6, TNF-α, IL-1β, NF-κB, and glial fibrillary acidic protein (GFAP) were measured using qPCR analysis. Results: Prenatal exposure to LPS resulted in up-regulated expression levels of IL-6, TNF-α, NF-κB, and GFAP in the hippocampus of adult pups. Moreover, offspring from LPS group showed an increased astrocyte density in CA1 region with no histological alterations in CA1 and CA3 areas. Conversely, maternal zinc supplementation ameliorated these inflammatory alterations induced by LPS. Discussion: This study provides support for the premise that zinc supplementation during pregnancy might be an early treatment option to inhibit hippocampal inflammation induced by the maternal immune response to infectious agents.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Animalmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal Zinc Supplementation Ameliorates Hippocampal Astrocytes Activation and Inflammatory Cytokines Expression Induced by Lipopolysaccharide in a Rat Model of Maternal Immune Activation

Savareh

Davoodian

Mousaviyan

et al. 2022

BCN

Self Cite

View full text Add to dashboard Cite

show abstract

“…Another research showed that microglia had abnormal motility and cytokine-release ability. And the microglial density increased with maternal LPS treatment ( 38 – 40 ). Furthermore, MIA could affect mRNA level, protein level and membrane surface protein level of CX3CL1-CX3CR1 and CD200-CD200R signaling pathways in hippocampus and frontal cortex of the offspring ( 41 ).…”

Section: The Link Between Schizophrenia and Microglia In Animal Modelsmentioning

confidence: 99%

New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment

Wang²,

Yuan³

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

Characterized by psychotic symptoms, negative symptoms and cognitive deficits, schizophrenia had a catastrophic effect on patients and their families. Multifaceted reliable evidence indicated that schizophrenia is a neurodevelopmental disorder. Microglia, the immune cells in central nervous system, related to many neurodevelopmental diseases. Microglia could affect neuronal survival, neuronal death and synaptic plasticity during neurodevelopment. Anomalous microglia during neurodevelopment may be associated with schizophrenia. Therefore, a hypothesis proposes that the abnormal function of microglia leads to the occurrence of schizophrenia. Nowadays, accumulating experiments between microglia and schizophrenia could afford unparalleled probability to assess this hypothesis. Herein, this review summarizes the latest supporting evidence in order to shed light on the mystery of microglia in schizophrenia.

show abstract

“…Diversos modelos animais de esquizofrenia apresentaram ativação microglial em áreas relacionadas com a fisiopatologia deste transtorno, inclusive, os modelos baseados em antagonismo de NMDAR, como também demonstrado nos resultados do presente trabalho (Nakki et al, 1996;Arif et al, 2007;Chamera et al, 2021;Mousaviyan et al, 2021;Shelton et al, 2021). Curiosamente, antipsicóticos atípicos parecem reverter a ativação microglial.…”

Section: Discussionunclassified

Mecanismos celulares e neuroquímicos do efeito tipo-antipsicótico do canabidiol: envolvimento dos receptores 5-HT1A e CB2

Silva¹

View full text Add to dashboard Cite

A minha mãe, Rosemeire, força motriz e inspiradora. Uma companheira de vida e de existência. A pessoa que eu mais admiro e me espelho. Ao meu irmão, Vinícius, o curioso que me inspira. O cientista nato. O irmão que me incentiva a sonhar e acreditar nos meus sonhos. Ao meu pai, Itamar, outro curioso. Que me mostrou o que é ciência quando eu nem poderia imaginar minha trajetória profissional. O que acredita em mim e me motiva a ser sempre mais. Ao Prof. Dr. Francisco Silveira Guimarães, por tanto! Por me ensinar muito sobre muita coisa. Por transformar tantas pessoas e nos mostrar uma visão mais expandida do mundo. Que desde o mestrado me acolheu em seu laboratório e que me transformou profissionalmente ao longo de tantos anos. Pela ótima convivência que sempre fomentou em todos os ambientes, sempre regado a café ou um bom mate. Por confiar em mim e no meu trabalho e apoiar todas as minhas ideias. Muita gratidão por tudo!

show abstract

Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation

Cited by 16 publications

References 60 publications

Prenatal Zinc Supplementation Ameliorates Hippocampal Astrocytes Activation and Inflammatory Cytokines Expression Induced by Lipopolysaccharide in a Rat Model of Maternal Immune Activation

Prenatal Zinc Supplementation Ameliorates Hippocampal Astrocytes Activation and Inflammatory Cytokines Expression Induced by Lipopolysaccharide in a Rat Model of Maternal Immune Activation

New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment

Mecanismos celulares e neuroquímicos do efeito tipo-antipsicótico do canabidiol: envolvimento dos receptores 5-HT1A e CB2

Contact Info

Product

Resources

About