Zinc supplementation in children with cholera in Bangladesh: randomised controlled trial

Sk, Roy; Hossain, M.; Khatun, Wajiha; Chakraborty, Barnali; Chowdhury, Sadia; Begum, Afroza; Mah‐E‐Muneer, Syeda; Shafique, Sohana; Khanam, Mansura; Chowdhury, Rajib Nayan

doi:10.1136/bmj.39416.646250.ae

Cited by 90 publications

(53 citation statements)

References 11 publications

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“…El zinc disminuye la duración de la diarrea por Klebsiella (20), Shigella (21) o Cólera (22), en cambio no parece afectar la diarrea por E. coli (9,20) e inclusive podría ser perjudicial en los casos de rotavirus (8,20).…”

Section: Diarrea Y Micronutrientesunclassified

Diarrea y micronutrientes

Zea

Ochoa

2013

Rev Med Hered

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Section: Diarrea Y Micronutrientesunclassified

Diarrea y micronutrientes

Zea

Ochoa

2013

Rev Med Hered

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“…8 Oral zinc in children under 5 y of age, although not essential for treatment, has been found to be important in assisting with regeneration of the intestinal epithelium and has shown to reduce duration and severity of diarrheal episodes, as well as possibly preventing future episodes of diarrhea for up to 3 months. [9][10][11] Antimicrobial therapy as an adjunct to fluid resuscitation has been shown to decrease the duration and volume of diarrhea by approximately 50% in cholera patients with severe dehydration. 12,13 In addition, antibiotics also contribute to stopping the excretion of vibrio more rapidly, reducing the risk of transmission when the patient returns to the community.…”

Section: Introductionmentioning

confidence: 99%

Achievements and challenges for the use of killed oral cholera vaccines in the global stockpile era

Desai

Pezzoli

Alberti

et al. 2016

Human Vaccines & Immunotherapeutics

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Cholera remains an important but neglected public health threat, affecting the health of the poorest populations and imposing substantial costs on public health systems. Cholera can be eliminated where access to clean water, sanitation, and satisfactory hygiene practices are sustained, but major improvements in infrastructure continue to be a distant goal. New developments and trends of cholera disease burden, the creation of affordable oral cholera vaccines (OCVs) for use in developing countries, as well as recent evidence of vaccination impact has created an increased demand for cholera vaccines. The global OCV stockpile was established in 2013 and with support from Gavi, has assisted in achieving rapid access to vaccine in emergencies. Recent WHO prequalification of a second affordable OCV supports the stockpile goals of increased availability and distribution to affected populations. It serves as an essential step toward an integrated cholera control and prevention strategy in emergency and endemic settings.

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“…The addition of zinc supplements and antibiotics also have been shown to be beneficial in the treatment of cholera. 4,5 For decades, probiotics -defined as a live microorganism that confers benefit to the host -have been utilised in humans to treat and prevent gastrointestinal diseases. Saccharomyces cerevisiae var.…”

Section: Introductionmentioning

confidence: 99%

Saccharomyces boulardiiand bismuth subsalicylate as low-cost interventions to reduce the duration and severity of cholera

Sheele

Cartowski

Dart

et al. 2015

Pathogens and Global Health

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We conducted a randomised single-blinded clinical trial of 100 cholera patients in Port-au-Prince, Haiti to determine if the probiotic Saccharomyces cerevisiae var. boulardii and the anti-diarrhoeal drug bismuth subsalicylate (BS) were able to reduce the duration and severity of cholera. Subjects received either: S. boulardii 250 mg, S. boulardii 250 mg capsule plus BS 524 mg tablet, BS 524 mg, or two placebo capsules every 6 hours alongside standard treatment for cholera. The length of hospitalisation plus the number and volume of emesis, stool and urine were recorded every 6 hours until the study subject was discharged (n583), left against medical advice (n511), or requested removal from the study (n56). There were no reported deaths or adverse study-related events. There were no statistically significant differences between the study arms and the outcomes of interest.

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Zinc supplementation in children with cholera in Bangladesh: randomised controlled trial

Abstract: Objective To investigate the impact of zinc supplementation in children with cholera.

Cited by 90 publications

References 11 publications

Diarrea y micronutrientes

Diarrea y micronutrientes

Achievements and challenges for the use of killed oral cholera vaccines in the global stockpile era

Saccharomyces boulardiiand bismuth subsalicylate as low-cost interventions to reduce the duration and severity of cholera

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