Zinc Supplementation Increases the Level of Serum Insulin-Like Growth Factor-I but Does Not Promote Growth in Infants with Nonorganic Failure to Thrive

Hershkovitz, Eli; Printzman, Ludmilla; Segev, Yael; Levy, Jacov; Phillip, Moshe

doi:10.1159/000023461

Cited by 17 publications

(12 citation statements)

References 28 publications

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“…Our findings were supported by other studies [3-5,17,18] who reported that Zn supplementation was effective for inducing growth in short children with Zn deficiency in a rate similar to that in healthy children. However, in some studies, this effect was not observed [6,7]. Ninh et al [19] showed that Zn supplementation increased both weight and height after five months compared with placebo treatment but this was not the case in our study concerning the weight.…”

Section: Discussioncontrasting

confidence: 84%

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Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

2012

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BackgroundThe relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of Zn supplementation on these parameters.MethodsFifty pre-pubertal Egyptian children with short stature and Zn deficiency were compared to 50 age-, sex-, and pubertal stage- matched controls. All subjects were subjected to history, auxological assessment and measurement of serum Zn, IGF-1, insulin growth factor binding protein-3 (IGFBP-3); and basal and stimulated GH before and 3 months after Zn supplementation (50 mg/day).ResultsAfter 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P < 0.001), IGF-1 (P < 0.01), IGF-1 standard deviation score (SDS,P < 0.01) and IGFBP-3 (P = 0.042). Zn rose in all patients but reached normal ranges in 64 %, IGF-1 levels rose in 60 % but reached normal ranges in 40 % and IGFBP-3 levels rose in 40 % but reached reference ranges in 22 %. Growth velocity (GV) SDS did not differ between cases and controls (p = 0.15) but was higher in GH-deficient patients than non-deficient ones, both having Zn deficiency (p = 0.03).ConclusionSerum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.

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Section: Discussioncontrasting

confidence: 84%

“…Some studies have reported positive effects of Zn supplementation on growth in various groups of Zn-deficient children [3-5]. However, in some studies, this effect was not observed [6,7]. …”

Section: Introductionmentioning

confidence: 99%

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

2012

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“…It is now known that in mossy fiber terminals, as well as in other brain regions, vesicular zinc colocalizes in neurons using glutamate as a neurotransmitter (Beaulieu et al, 1992;Frederickson, 1989). The concentration of zinc within these vesicles has been estimated to be as high as millimolar levels (Assaf and Chung, 1984;Frederickson et al, 2000;Howell et al, 1984;Qian and Noebles, (Mackenzie and Oteiza, 2007;Telford and Fraker, 1995;Truong-Tran et al, 2000) Audition (Frederickson et al, 1988;Rubio and Juiz, 1998) Free radical management (Bray and Bettger, 1990;Powell, 2000;Prasad et al, 2004;Zago and Oteiza, 2001) Hormone activity (Hershkovitz et al, 1999;MacDonald, 2000;McNall et al, 1995) Immune efficiency (Fraker et al, 2000;Prasad, 1995Prasad, , 2008Rink and Kirchner, 2000;Ibs and Rink, 2003) Intracellular signaling (Cousins, 1998;Frederickson et al, 2005a,b;Prasad, 1995;Vallee and Auld, 1993) Learning and memory (long-term potentiation) Kodirov et al, 2006;Lu et al, 2000;Saito et al, 2000;Takeda et al, 2009) Motor coordination (Jo et al, 2000b;Vincent and Semba, 1989) Neurogenesis (Dvergsten, 1984a;Frederickson et al, 2000) Neuromodulation (Colvin et al, 2003(Colvin et al, , 2008Kay and Toth, 2008;…”

Section: Discovery Of Gluzinergic Neuronsmentioning

confidence: 99%

“…The requirement for zinc is most intimately linked to its vital role in regulating numerous aspects of cellular metabolism, including immune (Fraker et al, 2000;Prasad, 1995Prasad, , 2008Rink and Kirchner, 2000), protein (Vallee and Falchuk, 1993), hormone (Hershkovitz et al, 1999;MacDonald, 2000;McNall et al, 1995), antioxidant (Bray and Bettger, 1990;Powell, 2000;Prasad et al, 2004;Zago and Oteiza, 2001), transcription, and replication functions (Cousins, 1998;Vallee and Falchuk, 1993). On the other hand, overabundant levels of zinc can be cytotoxic, inducing apoptosis (Ibs and Rink, 2003;Mackenzie and Oteiza, 2007;Telford and Fraker, 1995) and neuronal death (Koh et al, 1996;Sensi and Jeng, 2004).…”

Section: Introductionmentioning

confidence: 99%

Zinc: The brain's dark horse

Bitanihirwe

Cunningham

2009

Synapse

240

154

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Zinc is a life-sustaining trace element, serving structural, catalytic, and regulatory roles in cellular biology. It is required for normal mammalian brain development and physiology, such that deficiency or excess of zinc has been shown to contribute to alterations in behavior, abnormal central nervous system development, and neurological disease. In this light, it is not surprising that zinc ions have now been shown to play a role in the neuromodulation of synaptic transmission as well as in cortical plasticity. Zinc is stored in specific synaptic vesicles by a class of glutamatergic or "gluzinergic" neurons and is released in an activity-dependent manner. Because gluzinergic neurons are found almost exclusively in the cerebral cortex and limbic structures, zinc may be critical for normal cognitive and emotional functioning. Conversely, direct evidence shows that zinc might be a relatively potent neurotoxin. Neuronal injury secondary to in vivo zinc mobilization and release occurs in several neurological disorders such as Alzheimer's disease and amyotrophic lateral sclerosis, in addition to epilepsy and ischemia. Thus, zinc homeostasis is integral to normal central nervous system functioning, and in fact its role may be underappreciated. This article provides an overview of zinc neurobiology and reviews the experimental evidence that implicates zinc signals in the pathophysiology of neuropsychiatric diseases. A greater understanding of zinc's role in the central nervous system may therefore allow for the development of therapeutic approaches where aberrant metal homeostasis is implicated in disease pathogenesis.

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“…Some studies have reported positive effects of Zn supplementation on growth in various groups of Zn-deficient children [33][34]. However, in some studies, this effect was not observed [35][36]. We aimed to assess GH-IGF-Zn axis in short children.…”

Section: Discussionmentioning

confidence: 99%

Zinc level in children with short stature

Сорокман¹,

Sokolnyk²,

Popelyuk³

et al. 2019

Ro J Pediatr.

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Introduction. The research carried out confirms the great importance of zinc in the processes of children'sgrowth and development. Aim. To investigate the zinc content in blood serum of children with short stature. Methods. We examined 42 children under supervision in the children's endocrinology department of the Chernivtsi Oblast Children's Hospital during 2011-2018, aged 3 to 15 years. The control group consisted of 44 children aged 3-15 years. Determined the level of growth hormone (GR), IGF-1 and zinc in the blood plasma. Results. It has been detected that the level of zinc in blood plasma is reducedin 90, 4% of children with short stature. On average, zinc level in the blood plasma of children with short stature was 0.71 ± 0.03 μg/ml, which is significantly lower (p˂0.001) than the mean zinc level in children in the control group -1.11 ± 0.02 μg/ml . In all age groups, there was a significant decrease in zinc values in plasma compared to those in the corresponding age group of the control group. In 28 (cases the level of zinc was quite low, in 10 cases it was very low and in the rest of the cases it had boundary indices. Indices of zinc in blood plasma in children with somatotropic insufficiency were the lowest and averaged 0.66 ± 0.03 μg/l, p˂0.05. Age and gender dependency of zinc level in blood plasma was not found. Conclusions. Zinc deficiency in plasma is observed in most children with short stature. Necessary for zinc deficiency correction in patients with short stature by diet expansion incorporating food enriched with the microelement or the designation of appropriate zinc preparations. Diet expansion may be the subject of further research.

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Zinc Supplementation Increases the Level of Serum Insulin-Like Growth Factor-I but Does Not Promote Growth in Infants with Nonorganic Failure to Thrive

Cited by 17 publications

References 28 publications

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

Zinc: The brain's dark horse

Zinc level in children with short stature

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