Zinc Transfer during Hemodialysis in Chronic Renal Failure Patients

Hosokawa, Shinichi; Kohira, Seigo; Imai, Tetsuya; Tomoyoshi, T; Nishio, Takeshi; Sawanishi, K

doi:10.1159/000166459

Cited by 3 publications

(3 citation statements)

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“…This change occurred mainly by hemoconcentration and partially by diffusion as we previously reported [3]. The percent of ultrafiltrable zinc fraction was about 10% in total serum zinc of uremic patients [6], We did not find any significant difference between corpuscular zinc lev els before dialysis (1,299 ±146 pg/dl) and after dialysis 1,302± 144 ug/dl; (table I).…”

Section: Discussionsupporting

confidence: 69%

“…Both nickel and zinc have been found to be deficient in the serum of chronic hemodialysis patients [2,3]. In the 30 patients enrolled in this study, serum nickel levels before dialysis were 0.22±0.03 ug/dl, significantly lower than in the 30 normal subjects (0.56 ± 0.08 ug/dl).…”

Section: Discussionmentioning

confidence: 65%

“…[1,2]. Serum zinc defi ciency in chronic hemodialysis patients has been known to cause anorexia, slow wound-healing and testicular atrophy [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Serum and Corpuscular Nickel and Zinc in Chronic Hemodialysis Patients

Hosokawa

Nishitani

Umemura

et al. 1987

Nephron

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Serum and corpuscular nickel and zinc concentrations in 30 chronic hemodialysis patients were examined. Serum nickel and zinc levels before dialysis were 0.22 ± 0.03 μg/dl (normal value: 0.56 ± 0.08 μg/dl) and 70.0 ± 13.4 μg/dl (normal value: 96 ± 8 μg/dl) low, respectively. However, corpuscular nickel and zinc levels before dialysis were high: 1.25 ± 0.24 μg/dl (normal value: 0.88 ± 0.17 μg/dl) and 1,299 ± 146 μg/dl (normal value: 1,120 ± 80 μg/dl). Serum zinc levels significantly increased after dialysis, but serum nickel concentrations did not significantly increase during dialysis. Corpuscular nickel and zinc concentrations did not significantly change during dialysis.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 65%

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Serum and Corpuscular Nickel and Zinc in Chronic Hemodialysis Patients

Hosokawa

Nishitani

Umemura

et al. 1987

Nephron

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Relationship between haemodialysis anaemia and copper and zinc

Hosokawa

Nishitani

Umemura

et al. 1985

International Urology and Nephrology

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In fifteen chronic haemodialysis patients, serum and corpuscular copper and zinc concentrations were examined before and after dialysis. Serum copper levels were normal before dialysis and elevated after dialysis. However, corpuscular copper levels were low before dialysis and did not change after dialysis. Serum zinc concentrations before dialysis were low and significantly increased after dialysis. Corpuscular zinc levels before dialysis were high, but were unchanged after dialysis. There was a good correlation between serum zinc levels and red blood cell counts (RBC) and the value of haemoglobin (Hb), whereas we found no significant correlation between levels of serum or corpuscular copper and zinc, and of RBC, Hb, haematocrit or serum iron.

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Zinc and Chronic Renal Disease

Kimmel

1989

Seminars in Dialysis

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Summary Hypozincemia is common in patients with hronic renal insufficiency, and in patients with ESRD treated with peritoneal and hemodialysis. The causes of the decreased plasma zinc concentration in these patients are not completely understood, but poor nutritional zinc intake, diets associated with attempts to prevent the progression of renal failure, prescribed mineral supplements and medications, hypoalbuminemia, diminished gastrointestinal zinc absorption, increased urinary zinc excretion and redistribution of zinc into the intracellular fluid may all affect extracellular fluid zinc concentration and total body zinc stores in patients with chronic renal insufficiency. Zinc intake is probably the most important determinant of total body zinc status and plasma zinc concentration in these patients. The extent of true zinc depletion in this population is unknown, but it is likely to be an important problem. Patients with ESRD treated with hemodialysis may have similar reasons for developing hypozincemia, although it is unlikely that urinary losses play an important role in the development of negative zinc balance in this group. Although there is little evidence that hemodialysis results in net zinc losses, treatment effects may result in the redistribution of zinc from the extracellular fluid, resulting in the development of hypozincemia. Because such patients appear to be susceptible to the development of negative zinc balance due to gastrointestinal zinc losses, it would seem that they require increased levels of zinc intake. The similarity of the symptoms of zinc deficiency and uremia have prompted several studies of the effects of zinc supplementation on taste acuity, sexual, immune and neurologic function in hemodialysis patients, with some positive results. Patients with ESRD treated with CAPD may have hypozincemia as well, for reasons similar to those suggested in patients treated with hemodialysis. De‐spite protein losses in the peritoneal dialysate, net influx of zinc occurs during peritoneal dialysis. Since zinc deficiency may mediate some symptoms of uremia in patients treated for ESRD, clinicians should consider measuring circulating zinc concentration and providing therapeutic supplementation with zinc salts to hypozincemic patients with abnormalities of taste, sexual and immune function. Studies which have demonstrated a beneficial effect of zinc supplementation have used daily doses of 50 mg of zinc, given as zinc acetate, zinc chloride, or zinc sulfate. Zinc sulfate ingestion has been associated with gastrointestinal side effects. Zinc chloride has been added to dialysate in chronic studies to achieve a final zinc concentration of 400 μg/L, with beneficial results. The proper route, amount and length of such therapies, however, are currently unknown. Whether one zinc compound has clinical advantages compared to others must also await con‐trolled clinical evaluation.

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Zinc Transfer during Hemodialysis in Chronic Renal Failure Patients

Cited by 3 publications

References 5 publications

Serum and Corpuscular Nickel and Zinc in Chronic Hemodialysis Patients

Serum and Corpuscular Nickel and Zinc in Chronic Hemodialysis Patients

Relationship between haemodialysis anaemia and copper and zinc

Zinc and Chronic Renal Disease

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