Zinc transporters maintain longevity by influencing insulin/IGF‐1 activity in <i>Caenorhabditis elegans</i>

Novakovic, Stevan; Molesworth, Luke W.; Gourley, Taylin E.; Boag, Peter R.; Davis, Gregory F.

doi:10.1002/1873-3468.13725

Cited by 7 publications

(4 citation statements)

References 60 publications

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“…In addition, four (sic-2, acr-10, nca-2, and EVM0006162) out of five genes enriched in "ion transmembrane transporter activity" in 60‰ vs. 30‰ also had elongated 3 ′ UTRs despite the other one gene, zipt-16, having a shortened 3 ′ UTR. As expected, zipt-16 was also a significantly upregulated gene in 60‰ vs. 30‰ salinity (Supplementary Table S1), and has been reported to have interactions with daf-16 and skn-1 [59]. The two transcripts of zipt-16 (EVM0008784.1 and EVM0008784.2) were also significantly upregulated in 60‰ vs. 30‰ salinity (Supplementary Table S22).…”

Section: The Marine Nematode Exhibits Distinct Apa Usage Under Differ...supporting

confidence: 69%

Transcriptome Responses to Different Salinity Conditions in Litoditis marina, Revealed by Long-Read Sequencing

Zhang,

Xue,

Yang

et al. 2024

Genes

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The marine nematode Litoditis marina is widely distributed in intertidal zones around the globe, yet the mechanisms underlying its broad adaptation to salinity remain elusive. In this study, we applied ONT long-read sequencing technology to unravel the transcriptome responses to different salinity conditions in L. marina. Through ONT sequencing under 3‰, 30‰ and 60‰ salinity environments, we obtained 131.78 G clean data and 26,647 non-redundant long-read transcripts, including 6464 novel transcripts. The DEGs obtained from the current ONT lrRNA-seq were highly correlated with those identified in our previously reported Illumina short-read RNA sequencing data. When we compared the 30‰ to the 3‰ salinity condition, we found that GO terms such as oxidoreductase activity, cation transmembrane transport and ion transmembrane transport were shared between the ONT lrRNA-seq and Illumina data. Similarly, GO terms including extracellular space, structural constituents of cuticle, substrate-specific channel activity, ion transport and substrate-specific transmembrane transporter activity were shared between the ONT and Illumina data under 60‰ compared to 30‰ salinity. In addition, we found that 79 genes significantly increased, while 119 genes significantly decreased, as the salinity increased. Furthermore, through the GO enrichment analysis of 214 genes containing DAS, in 30‰ compared to 3‰ salinity, we found that GO terms such as cellular component assembly and coenzyme biosynthetic process were enriched. Additionally, we observed that GO terms such as cellular component assembly and coenzyme biosynthetic process were also enriched in 60‰ compared to 30‰ salinity. Moreover, we found that 86, 125, and 81 genes that contained DAS were also DEGs, in comparisons between 30‰ and 3‰, 60‰ and 30‰, and 60‰ and 3‰ salinity, respectively. In addition, we demonstrated the landscape of alternative polyadenylation in marine nematode under different salinity conditions This report provides several novel insights for the further study of the mechanisms by which euryhalinity formed and evolved, and it might also contribute to the investigation of salinity dynamics induced by global climate change.

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Section: The Marine Nematode Exhibits Distinct Apa Usage Under Differ...supporting

confidence: 69%

Transcriptome Responses to Different Salinity Conditions in Litoditis marina, Revealed by Long-Read Sequencing

Zhang,

Xue,

Yang

et al. 2024

Genes

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“…Furthermore, NBMI has the potential to chelate cellular metal ions with high affinity for free sulfhydryl groups such as Zn 2+ , which play important roles in the development of the animal [ [31] , [32] , [33] ]. Studies have shown that reducing Zn 2+ levels promotes nuclear localization of DAF-16 [ 32 , 34 ]. The interactive effects of NBMI and Zn 2+ in C. elegans deserve further investigations.…”

Section: Discussionmentioning

confidence: 99%

N,N’ bis-(2-mercaptoethyl) isophthalamide induces developmental delay in Caenorhabditis elegans by promoting DAF-16 nuclear localization

et al. 2020

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“…On the contrary, zinc supplementation was shown to decrease markers of oxidative stress and the production of pro-inflammatory cytokines in elderly patients. However, surplus zinc supplementation induces senescence of several cell types and reduces lifespan in Caenorhabditis elegans [91,92]. Further in this section, we focus on recent publications investigating the role of zinc in ageing-related functional and structural changes in the cardiovascular system.…”

Section: Aged Heartmentioning

confidence: 99%

“…of pro-inflammatory cytokines in elderly patients. However, surplus zinc sup tion induces senescence of several cell types and reduces lifespan in Caenorhab [91,92]. Further in this section, we focus on recent publications investigating zinc in ageing-related functional and structural changes in the cardiovascular It is known that some zinc transporters are upregulated by pro-inflammato such as IL-6 (interleukin 6), in an age-dependent manner.…”

Section: Aged Heartmentioning

confidence: 99%

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

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Zinc plays an important role in cardiomyocytes, where in exists in bound and histochemically reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through several Zn2+-transporters, its concentration and intracellular distribution may vary during normal cardiac function and pathological conditions, when the protein levels and efficacy of Zn2+ transporters can lead to zinc re-distribution among organelles in cardiomyocytes. Such dysregulation of cellular Zn2+ homeostasis leads to mitochondrial and ER stresses, and interrupts normal ER/mitochondria cross-talk and mitophagy, which subsequently, result in increased ROS production and dysregulated metabolic function. Besides cardiac structural and functional defects, insufficient Zn2+ supply was associated with heart development abnormalities, induction and progression of cardiovascular diseases, resulting in accelerated cardiac ageing. In the present review, we summarize the recently identified connections between cellular and mitochondrial Zn2+ homeostasis, ER stress and mitophagy in heart development, excitation–contraction coupling, heart failure and ischemia/reperfusion injury. Additionally, we discuss the role of Zn2+ in accelerated heart ageing and ageing-associated rise of mitochondrial ROS and cardiomyocyte dysfunction.

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Zinc transporters maintain longevity by influencing insulin/IGF‐1 activity in Caenorhabditis elegans

Cited by 7 publications

References 60 publications

Transcriptome Responses to Different Salinity Conditions in Litoditis marina, Revealed by Long-Read Sequencing

Transcriptome Responses to Different Salinity Conditions in Litoditis marina, Revealed by Long-Read Sequencing

N,N’ bis-(2-mercaptoethyl) isophthalamide induces developmental delay in Caenorhabditis elegans by promoting DAF-16 nuclear localization

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

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