Zingiber officinale and Panax ginseng ameliorate ulcerative colitis in mice via modulating gut microbiota and its metabolites

Wan, Yanan; Yang, Lei; Li, Huifang; Hui, R.; Zhu, Ke; Dong, Zhiling; Jiang, Shu; Shang, Erxin; Qian, Dawei; Duan, Jin‐Ao

doi:10.1016/j.jchromb.2022.123313

Cited by 20 publications

(8 citation statements)

References 56 publications

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“…The metabolomic analysis revealed metabolic profile alternations in response to the gut microbiota reprogrammed by a qingchang wenzhong decoction (QCWZD), especially enhanced Trp metabolism [ 54 ]. Gallnut tannic acid and the zingiber officinale–panax ginseng herb pair also stimulated the growth of the beneficial bacteria and suppressed the growth of the pathogenic bacteria [ 55 , 56 ].…”

Section: Trp Metabolism In Gut Microbiotamentioning

confidence: 99%

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Gao

Yang

2022

Cells

156

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Tryptophan is an essential amino acid from dietary proteins. It can be metabolized into different metabolites in both the gut microbiota and tissue cells. Tryptophan metabolites such as indole-3-lactate (ILA), indole-3-acrylate (IAC), indole-3-propionate (IPA), indole-3-aldehyde (IAID), indoleacetic acid (IAA), indole-3-acetaldehyde and Kyn can be produced by intestinal microorganisms through direct Trp transformation and also, partly, the kynurenine (Kyn) pathway. These metabolites play a critical role in maintaining the homeostasis of the gut and systematic immunity and also potentially affect the occurrence and development of diseases such as inflammatory bowel diseases, tumors, obesity and metabolic syndrome, diseases in the nervous system, infectious diseases, vascular inflammation and cardiovascular diseases and hepatic fibrosis. They can not only promote the differentiation and function of anti-inflammatory macrophages, Treg cells, CD4+CD8αα+ regulatory cells, IL-10+ and/or IL-35+B regulatory cells but also IL-22-producing innate lymphoid cells 3 (ILC3), which are involved in maintaining the gut mucosal homeostasis. These findings have important consequences in the immunotherapy against tumor and other immune-associated diseases. We will summarize here the recent advances in understanding the generation and regulation of tryptophan metabolites in the gut microbiota, the role of gut microbiota-derived tryptophan metabolites in different immune cells, the occurrence and development of diseases and immunotherapy against immune-associated diseases.

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Section: Trp Metabolism In Gut Microbiotamentioning

confidence: 99%

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Gao

Yang

2022

Cells

156

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“…also proposed that ginseng polysaccharides exerted a protective effect against (DSS)-induced rat colitis through restoring the diversity and composition of gut microbiota, such as effectively upregulating the relative abundance of Ruminococcus, which also demonstrated that Ruminococcus might be involved in the progression of colitis occurrence ( 58 ). The combination treatment of Zingiber officinale and P. ginseng could ameliorate DSS ulcerative colitis via regulating the abundance of gut microbiome, including upregulating beneficial bacteria such as Muribaculaceae_norank, Lachnospiraceae NK4A136 group, and Akkermansia, and downregulating pathogenic bacteria such as Bacteroides, Parabacteroides, and Desulfovibrio ( 93 ). Another study also found that synergistic administration of American ginseng polysaccharide and American ginseng ginsenoside could improve gut microbiota diversity and restore gut microbiota composition, including upregulating the relative abundance of probiotics (Clostridiales, Bifidobacterium , and Lachnospiraceae), while together downregulating harmful bacteria ( Escherichia-Shigella and Peptococcaceae) ( 94 ).…”

Section: Effect Of Ginseng and Ginsenosides On Intestinal System Infl...mentioning

confidence: 99%

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

Zhao,

Zhang,

Zhang

2024

Front. Immunol.

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Intestinal inflammatory imbalance and immune dysfunction may lead to a spectrum of intestinal diseases, such as inflammatory bowel disease (IBD) and gastrointestinal tumors. As the king of herbs, ginseng has exerted a wide range of pharmacological effects in various diseases. Especially, it has been shown that ginseng and ginsenosides have strong immunomodulatory and anti-inflammatory abilities in intestinal system. In this review, we summarized how ginseng and various extracts influence intestinal inflammation and immune function, including regulating the immune balance, modulating the expression of inflammatory mediators and cytokines, promoting intestinal mucosal wound healing, preventing colitis-associated colorectal cancer, recovering gut microbiota and metabolism imbalance, alleviating antibiotic-induced diarrhea, and relieving the symptoms of irritable bowel syndrome. In addition, the specific experimental methods and key control mechanisms are also briefly described.

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“…This is exemplified by an animal study wherein prenatal maternal stress led to worse colitis in the offspring, which was also associated with DSV bloom in the offspring [ 37 ]. Interventions used to decrease the severity of IBD also reduced DSV bloom [ 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. Similarly, use of probiotics in the context of disease has a protective effect that is likely attributable to their competition or inhibition of DSV [ 45 , 46 ].…”

Section: Dsv and Diseasesmentioning

confidence: 99%

Desulfovibrio in the Gut: The Enemy within?

2023

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Desulfovibrio (DSV) are sulfate-reducing bacteria (SRB) that are ubiquitously present in the environment and as resident commensal bacteria within the human gastrointestinal tract. Though they are minor residents of the healthy gut, DSV are opportunistic pathobionts that may overgrow in the setting of various intestinal and extra-intestinal diseases. An increasing number of studies have demonstrated a positive correlation between DSV overgrowth (bloom) and various human diseases. While the relationship between DSV bloom and disease pathology has not been clearly established, mounting evidence suggests a causal role for these bacteria in disease development. As DSV are the most predominant genera of SRB in the gut, this review summarizes current knowledge regarding the relationship between DSV and a variety of diseases. In this study, we also discuss the mechanisms by which these bacteria may contribute to disease pathology.

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Zingiber officinale and Panax ginseng ameliorate ulcerative colitis in mice via modulating gut microbiota and its metabolites

Cited by 20 publications

References 56 publications

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

Desulfovibrio in the Gut: The Enemy within?

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