Zingiber officinale attenuates 6-hydroxydopamine induced oxidative stress and apoptosis through AKT, Nrf2, MAPK, NF-κB signaling pathway in PC12 cells

Hao, Suping; Cho, Byoung Ok; Wang, Zhen; Shin, Jae Young; SHIN, Da Jeong; Jang, Seon Il

doi:10.1590/fst.111221

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…Ginger also increased erythroid-2-related factor 2 (Nrf2) gene expression and decrease nuclear factor kappa (NFkB) in animal testis [14]. Nrf2 have to regulate antioxidant molecule and enzyme and isolated in cytoplasm in general condition [17]. Ginger has multiple bioactive compounds including 6-gingerol, 6-shogaol, gingerdions, gingerdiol, paradols, 6-dehydrogingerols, 12-gingerol, and etc.…”

Section: Introductionmentioning

confidence: 99%

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Decoction of ginger (Zingiber officinale Roscoe var Roscoe) attenuate the oxidation stress in hyperlipidemia rat (Rattus norvegicus)

Mahmudati¹,

Prihanta²,

Wahyono³

et al. 2023

World J. Adv. Res. Rev.

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Based on UNICEF data, overweight and obesity increased across all age and income groups. Overweight has a risk of developing hyperlipidemia and caused increase free radical and lead to oxidative stress. It’s result in cell damage and impacts on several diseases among others diabetes mellitus. Many Medicinal Plant have biochemical compound which is an important concern because of the potential to reduce free radicals. 0ne of them is ginger (Zingiber officinale Roscoe var Roscoe). Medicinal plant generally is usually used with various extraction method to obtain the required chemical content. Information of ginger for reduce free radical with maceration extraction method has been reported in previous studies but little information with decoction extraction method. This study aims to determine the reduction of free radicals with MDA (malondialdehyde) as a marker and increased antioxidant activity with SOD (superoxide dismutase) as a marker after administration of ginger. This research was used the true experimental with the randomized posttest only control group design. The groups of experimental were divided into three which G1: control normal G2: High Fat Diet (HFD), G3: HFD + Zingiber officinale Roscoe var Roscoe (ZO) 5 g/day. The period of study was 6 weeks. The level of liver MDA and SOD were investigated by spectrophotometer UV Vis. Based on ANAVA showed that HFD rat increase of body fat weight and MDA (p<0,05) and reduced of total antioxidant SOD (p<0.05). The conclusion of this research decoction of Zingiber officinale Roscoe var Roscoe could attenuate of lipid peroxidation induce by HFD.

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Section: Introductionmentioning

confidence: 99%

“…Based on recent research showed that ginger can inhibit apoptosis and oxidative stress in PD model (6-OHDHA-indiced PCl12 cells). Reduction of stress oxidation sees thorough enhancement of antioxidant activity such as catalase, SOD, and another important marker [17].…”

Section: Introductionmentioning

confidence: 99%

Decoction of ginger (Zingiber officinale Roscoe var Roscoe) attenuate the oxidation stress in hyperlipidemia rat (Rattus norvegicus)

Mahmudati¹,

Prihanta²,

Wahyono³

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…To maintain homeostasis, they are mostly eliminated by defense mechanisms, such as the antioxidant defense system, which includes glutathione peroxidase (GPx) catalase (CAT), and superoxide dismutase (SOD) (Wang, 2022;Jóźwiak & Politycka, 2019). However, when the rate of ROS generation exceeds that of elimination, homeostasis is perturbed, resulting in cellular damage and the loss of normal function, which can cause diseases like arteriosclerosis and cardiovascular disease as well as accelerated aging (Wilmes et al, 2020;Hao et al, 2022). Therefore, in-depth research on various methods for efficient ROS regulation is ongoing, especially focusing on natural bioactive compounds or secondary metabolites with antioxidant activity, which can activate antioxidant enzymes (Donadio et al, 2021;Setyorini & Antarlina, 2022).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of bioactive compounds through bioconversion of Oenanthe javanica using Lactiplantibacillus plantarum

et al. 2023

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The purpose of this study is to investigate the effect of bioconverted Oenanthe javanica extract (BOE) using Lactiplantibacillus plantarum SM4 on production of bioactive compounds. Response surface methodology was used to determine the optimal ultrasound-assisted extraction conditions including the extraction time, extraction temperature, and ethanol concentration for the enhancement of bioactive compounds production. The predicted optimum UAE conditions were extraction time of 26.0 min, extraction temperature of 92.8 °C, and 59.9% ethanol, respectively, and 5.14 mg GAE/g DM of TPC and 0.59 mg QE/g DM of TFC were produced under the optimum condition. Then, O. javanica extraction (OJE) has been bioconverted by using L. plantarum SM4 to increase the bioactive compounds. In HPLC-mass spectrometry analyses, higher concentration of p-coumaric acid was identified in BOE than in OJE, and chlorogenic acid in OJE was converted to quinic acid, confirming an increase in bioactive compounds by bioconversion. Thus, we have concluded that optimization of UAE and the BOE is an effective process for enhancement bioactive compounds from O. Javanica and this finding provides a scientific basis of bioactive compounds in natural product can be utilized as food, cosmetics, and pharmaceutical materials from BOE.

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IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells

Siwecka,

Galita,

Granek

et al. 2024

IJMS

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Parkinson’s disease (PD) is a neurodegenerative disorder which affects dopaminergic neurons of the midbrain. Accumulation of α-synuclein or exposure to neurotoxins like 6-hydroxydopamine (6-OHDA) induces endoplasmic reticulum (ER) stress along with the unfolded protein response (UPR), which executes apoptosis via activation of PERK/CHOP or IRE1/JNK signaling. The present study aimed to determine which of these pathways is a major contributor to neurodegeneration in an 6-OHDA-induced in vitro model of PD. For this purpose, we have applied pharmacological PERK and JNK inhibitors (AMG44 and JNK V) in differentiated SH-SY5Y cells exposed to 6-OHDA. Inhibition of PERK and JNK significantly decreased genotoxicity and improved mitochondrial respiration, but only JNK inhibition significantly increased cell viability. Gene expression analysis revealed that the effect of JNK inhibition was dependent on a decrease in MAPK10 and XBP1 mRNA levels, whereas inhibition of either PERK or JNK significantly reduced the expression of DDIT3 mRNA. Western blot has shown that JNK inhibition strongly induced the XBP1s protein, and inhibition of each pathway attenuated the phosphorylation of eIF2α and JNK, as well as the expression of CHOP. Collectively, our data suggests that targeting the IRE1/JNK pathway of the UPR is a more effective option for PD treatment as it simultaneously affects more than one pro-apoptotic pathway.

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Zingiber officinale attenuates 6-hydroxydopamine induced oxidative stress and apoptosis through AKT, Nrf2, MAPK, NF-κB signaling pathway in PC12 cells

Cited by 3 publications

References 35 publications

Decoction of ginger (Zingiber officinale Roscoe var Roscoe) attenuate the oxidation stress in hyperlipidemia rat (Rattus norvegicus)

Decoction of ginger (Zingiber officinale Roscoe var Roscoe) attenuate the oxidation stress in hyperlipidemia rat (Rattus norvegicus)

Enhancement of bioactive compounds through bioconversion of Oenanthe javanica using Lactiplantibacillus plantarum

IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells

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