Zingiber officinale Rosc. essential oil, a review on its composition and bioactivity

Mahboubi, Mohaddese

doi:10.1186/s40816-018-0097-4

Cited by 135 publications

(85 citation statements)

References 56 publications

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“…The ligands were prepared using the LigPrep module of (Farag et al, 2017;Kamel & Saleh, 2000;Lanzotti 2012;Martins et al, 2016;Thomson & Ali, 2003) 3 Ginger Zingiber officinale Roscoe. (Zingiberaceae) ZO_01-ZO_99 (Feng et al, 2011;Mahboubi, 2019;Pancharoen et al, 2000) 4 Turmeric Curcuma longa L. (Zingiberaceae) CL_01-CL_161 (Meng et al, 2018) 5 Black piper Piper nigrum L. (Piperaceae) PN_01-PN_175 (Ee et al, 2009;Rasheed et al, 2005;Salehi et al, 2019;Takooree et al, 2019) 6 Red chilli Capsicum annuum L. (Solanaceae) CA_01-CA_120 (Antonio et al, 2018;Imran et al, 2018;Tundis et al, 2011) 7 Fenugreek (Methi) Trigonella foenum-graecum L. (Fabaceae)…”

Section: Ligand Preparationmentioning

confidence: 99%

Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study

Sen¹,

Debnath

et al. 2020

Journal of Biomolecular Structure and Dynamics

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The outbreak of novel coronavirus disease (COVID-19) caused by SARS-CoV-2 poses a serious threat to human health and world economic activity. There is no specific drug for the treatment of COVID-19 patients at this moment. Traditionally, people have been using spices like ginger, fenugreek and onion, etc. for the remedy of a common cold. This work identifies the potential inhibitors of the main protease (M pro) and spike (S) receptor of SARS-CoV-2 from 10 readily available spices. These two proteins, S and M pro , play an important role during the virus entry into the host cell, and replication and transcription processes of the virus, respectively. To identify potential molecules an in-house databank containing 1040 compounds was built-up from the selected spices. Structure-based virtual screening of this databank was performed with two important SARS-CoV-2 proteins using Glide. Top hits resulted from virtual screening (VS) were subjected to molecular docking using AutoDock 4.2 and AutoDock Vina to eliminate false positives. The top six hits against M pro and top five hits against spike receptor subjected to 130 ns molecular dynamic simulation using GROMACS. Finally, the compound 1-, 2-, 3and 5-M pro complexes, and compound 17-, 18-, 19-, 20and 21spike receptor complexes showed stability throughout the simulation time. The ADME values also supported the drug-like nature of the selected hits. These nine compounds are available in onion, garlic, ginger, peppermint, chili and fenugreek. All the spices are edible and might be used as home remedies against COVID-19 after proper biological evaluation.

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Section: Ligand Preparationmentioning

confidence: 99%

Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study

Sen¹,

Debnath

et al. 2020

Journal of Biomolecular Structure and Dynamics

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“…Due to its unique fragrance and biological activity, it has a very broad development prospects in the pharmaceutical, food, and cosmetics industries [ 15 ]. In particular, GEO is generally considered a safe natural compound, which has its application value in the treatment of gastrointestinal and respiratory diseases [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Mechanism of Ginger Essential Oil against Escherichia coli and Staphylococcus aureus

et al. 2020

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Though essential oils exhibit antibacterial activity against food pathogens, their underlying mechanism is understudied. We extracted ginger essential oil (GEO) using supercritical CO2 and steam distillation. A chemical composition comparison by GC-MS showed that the main components of the extracted GEOs were zingiberene and α-curcumene. Their antibacterial activity and associated mechanism against Staphylococcus aureus and Escherichia coli were investigated. The diameter of inhibition zone (DIZ) of GEO against S. aureus was 17.1 mm, with a minimum inhibition concentration (MIC) of 1.0 mg/mL, and minimum bactericide concentration (MBC) of 2.0 mg/mL. For E. coli, the DIZ was 12.3 mm with MIC and MBC values of 2.0 mg/mL and 4.0 mg/mL, respectively. The SDS-PAGE analysis revealed that some of the electrophoretic bacterial cell proteins bands disappeared with the increase in GEO concentration. Consequently, the nucleic acids content of bacterial suspension was raised significantly and the metabolic activity of bacteria was markedly decreased. GEO could thus inhibit the expression of some genes linked to bacterial energy metabolism, tricarboxylic acid cycle, cell membrane-related proteins, and DNA metabolism. Our findings speculate the bactericidal effects of GEO primarily through disruption of the bacterial cell membrane indicating its suitability in food perseveration.

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“…Many species of the Zingiberaceae are rich in essential oil and cultivated for their various applications in dyes, spices, ornamental, cosmetics, medicine, and food industries [ 7 , 8 ]. The essential oils from the Zingiberaceae plants have been demonstrated to have multiple bioactivities, such as antimicrobial, anti-inflammatory, anticancer, antimutagenic, analgesic, anti-allergic, anti-ulcer, insecticidal, and immunomodulatory activities [ 5 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antibacterial, Anti-Inflammatory, and Enzyme Inhibitory Activities of Essential Oil from Rhynchanthus beesianus Rhizome

Zhao

Chen

et al. 2020

Molecules

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Rhynchanthus beesianus W. W. Smith, an edible, medicinal, and ornamental plant, is mainly cultivated in China and Myanmar. The essential oil (EO) from R. beesianus rhizome has been used as an aromatic stomachic in China. The chemical composition and biological activities of EO from R. beesianus rhizome were reported for the first time. Based on gas chromatography with flame ionization or mass selective detection (GC-FID/MS) results, the major constituents of EO were 1,8-cineole (47.6%), borneol (15.0%), methyleugenol (11.2%), and bornyl formate (7.6%). For bioactivities, EO showed a significant antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Proteus vulgaris with the diameter of the inhibition zone (DIZ) (8.66–10.56 mm), minimal inhibitory concentration (MIC) (3.13–6.25 mg/mL), and minimal bactericidal concentration (MBC) (6.25–12.5 mg/mL). Moreover, EO (128 μg/mL) significantly inhibited the production of proinflammatory mediators nitric oxide (NO) (92.73 ± 1.50%) and cytokines tumor necrosis factor-α (TNF-α) (20.29 ± 0.17%) and interleukin-6 (IL-6) (61.08 ± 0.13%) in lipopolysaccharide (LPS)-induced RAW264.7 macrophages without any cytotoxic effect. Moreover, EO exhibited significant acetylcholinesterase (AChE) inhibitory activity (the concentration of the sample that affords a 50% inhibition in the assay (IC50) = 1.03 ± 0.18 mg/mL) and moderate α-glucosidase inhibition effect (IC50 = 11.60 ± 0.25 mg/mL). Thus, the EO could be regarded as a bioactive natural product and has a high exploitation potential in the cosmetics and pharmaceutical industries.

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Zingiber officinale Rosc. essential oil, a review on its composition and bioactivity

Cited by 135 publications

References 56 publications

Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study

Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study

Antibacterial Activity and Mechanism of Ginger Essential Oil against Escherichia coli and Staphylococcus aureus

Chemical Composition, Antibacterial, Anti-Inflammatory, and Enzyme Inhibitory Activities of Essential Oil from Rhynchanthus beesianus Rhizome

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