Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials

Oke, Gracious Oluwamayowa; Abiodun, Adegboyega Adeleke; Imafidon, Christian Eseigbe; Monsi, Barinem Fortune

doi:10.1016/j.toxrep.2019.05.001

Cited by 22 publications

(19 citation statements)

References 38 publications

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“…In contrast, CCl 4 may be responsible for its adverse oxidative effects by converting to its toxic free radical via hepatic microsomal cytochrome P 450 system [24,39]. Our results were in accord with numerous studies indicating hepatotoxicity of CCl 4 in rats [26,28,40,41], broiler chickens [16,34], and Japanese quail [8,36]. Similarly, CCl 4 -mediated hepatic damage was reported in male hamster [33].…”

Section: Discussionsupporting

confidence: 90%

“…Obtained results were in accord with the reports demonstrating greater blood serum function of AST and ALT in CCl 4 intoxicated broilers [16,34] and Wistar rats [28], AST in Japanese quail [35], and ALP in Japanese quail [36].…”

Section: Discussionsupporting

confidence: 89%

“…CCl 4 is converted to its toxic trichloromethyl free radical through hepatic microsomal cytochrome P 450 [3], with the potential oxidative stress which results in DNA destruction, cellular structure devastation, and finally disturbance of hepatic cellular metabolism [24]. Our findings were in line with reports showing hypoproteinaemia and albuminuria in CCl 4 intoxicated broilers [16,25], rats [[26], [27], [28]], and Japanese quail [8]. In contrast, it has been commented that silymarin stimulates protein synthesis through activating the RNA synthesis of ribosomes [29].…”

Section: Discussionsupporting

confidence: 89%

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Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model

et al. 2019

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

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Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model

et al. 2019

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“…The increased level of these reproductive hormones accompanying AECUL administration demonstrates the fertility‐boosting potential of the extract. Some phytochemicals in the extract are flavonoids and tannins which are reputed to have antioxidant and anti‐inflammatory potential . Since cimetidine caused alterations in the antioxidant system, AECUL may have reversed the suppression of hormonal release and expression via restoration of normal antioxidant status.…”

Section: Discussionmentioning

confidence: 99%

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Onwuemene

Imafidon

Ayoka

2019

Anim Models and Exp Med

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Background The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself. Treatment or management therapy is often expensive. This study investigated the effects of acetone extract of a local plant (Curcuma longa) in a Wistar rat model of cimetidine‐induced pituitary‐testicular dysfunction. Methods Thirty‐five male Wistar rats were divided into 7 groups of 5 rats. After a phytochemical screening of an acetone extract of C. Longa, cimetidine and the extract at three doses, 200, 400 and 600 mg/kg, were orally co‐administered to the rats for 28 consecutive days. Comparisons were made (at P < 0.05) against a control (2 mL/kg distilled water), a standard treatment group (cimetidine + 50 mg/kg vitamin C), a toxic group (60 mg/kg cimetidine) and a group receiving extract alone. Results Cimetidine administration was associated with deleterious alterations to sperm motility, sperm count and sperm viability, as well as derangements in the plasma levels of FSH, LH and testosterone (P < 0.05). Both brain and testicular GSH and TBARS levels were significantly altered following cimetidine administration, and distortions were seen in the pituitary and testicular histoarchitecture. These changes were significantly normalized by co‐administration of graded doses of the extract, with an associated improvement of both pituitary and testicular histology. Conclusion Acetone extract of C. Longa normalized cimetidine‐induced pituitary‐testicular dysfunction in Wistar rats. This presents the extract as a potential nutraceutical choice against chemically induced reproductive toxicity.

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“…Environmental triggers, such as exposure to cigarette smoke, UV radiation, heavy metal ions, ozone, allergens, drugs or toxins, pollutants, pesticides, or insecticides, may all contribute to the increase of ROS production in cells (Antunes dos Santos et al, 2018;Mahajan et al, 2018;Oke et al, 2019).…”

Section: Exogenous Rosmentioning

confidence: 99%

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

et al. 2020

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Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.

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Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials

Abstract: Graphical abstract

Cited by 22 publications

References 38 publications

Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model

Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

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