Zingiberene attenuates hydrogen peroxide-induced toxicity in neuronal cells

Toğar, Başak; Türkez, Hasan; Stefano, A. Di; Tatar, Abdülgani; Çetin, Damla

doi:10.1177/0960327114538987

Cited by 20 publications

(9 citation statements)

References 50 publications

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“…Zingiberene, the chief component of the Z. officinale essential oil here analyzed, is a monocyclic sesquiterpene hydrocarbon with natural antioxidant and cytotoxic activities: it is capable of protecting against H 2 O 2 -induced cytotoxicity and oxidative DNA damage in neuronal cells [35] as well as inhibiting the growth of lymphocytic cells in a dose-dependent manner [36]. Furthermore, high zingiberene content in tomato plants provides resistance against arthropod pests including spider mite ( Tetranychus urticae ) and whitefly ( Bemisia tabaci ) [37,38].…”

Section: Resultsmentioning

confidence: 99%

Ginger and Turmeric Essential Oils for Weed Control and Food Crop Protection

Ibáñez

Blázquez

2019

Plants

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Ginger and turmeric are two food ingredients that are in high demand due to their flavor and positive effects on health. The biological properties of these spices are closely related to the aromatic compounds they contain. The chemical compositions of their essential oils and their in vitro phytotoxic activity against weeds (Portulaca oleracea, Lolium multiflorum, Echinochloa crus-galli, Cortaderia selloana, and Nicotiana glauca) and food crops (tomato, cucumber, and rice) were studied. Forty-one compounds, accounting for a relative peak area of 87.7% and 94.6% of turmeric and ginger essential oils, respectively, were identified by Gas Chromatography–Mass Spectrometry analysis. Ginger essential oil with α-zingiberene (24.9 ± 0.8%), β-sesquiphelladrene (11.7 ± 0.3%), ar-curcumene (10.7 ± 0.2%), and β-bisabolene (10.5 ± 0.3%) as the main compounds significantly inhibited the seed germination of P. oleracea, L. multiflorum, and C. selloana at the highest dose (1 µL/mL) assayed, as well as the hypocotyl and radicle growth of the weeds. Turmeric essential oil with ar-turmerone (38.7 ± 0.8%), β-turmerone (18.6 ± 0.6%), and α-turmerone (14.2 ± 0.9%) as principal components significantly inhibited the seed germination of C. selloana and hypocotyl and radicle growth of weeds (the latter in particular) at the highest dose, whereas it did not affect either the seed germination or seedling growth of the food crops. Turmeric essential oil can be an effective post-emergent bioherbicide against the tested weeds without phytotoxicity to crops.

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Section: Resultsmentioning

confidence: 99%

Ginger and Turmeric Essential Oils for Weed Control and Food Crop Protection

Ibáñez

Blázquez

2019

Plants

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“…For example, high levels of ROS-mediated oxidative stress can damage the structure and functions of endothelial cells, and contribute to pathogenesis of hypertension, diabetes, inflammation and atherosclerosis [ 58 , 59 ]. The assays of H 2 O 2 -induced death of endothelial cells or neuronal cells are commonly used in vitro models for determining antioxidant effects on oxidative stress [ 31 , 32 , 60 , 61 ]. Using these assays, other have shown that H 2 O 2 is highly permeable to cell membrane [ 62 ] and can increase production of O 2 − by activating NADPH oxidase and eNOS uncoupling [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Entacapone is an Antioxidant More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-Induced Cell Death

et al. 2016

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BackgroundEntacapone (ENT), a clinical drug for the treatment of Parkinson’s disease, has been shown to have antioxidant effects, but little is known about its antioxidant mechanisms. The objective of the current study was to determine the antioxidant activity of ENT against different species of oxidants and compared it with that of vitamin C and vitamin E. We also determined the effect of ENT on oxidative stress-induced cell death in human umbilical vein endothelial cells (HUVECs).Material/MethodsThe total antioxidant activities of ENT, vitamin C and vitamin E were determined with a standard DPPH-scavenging assay. Specific assays to determine ENT’s scavenging activity on hypochlorous acid (HOCl), peroxynitrite (ONOO−), and hydrogen peroxide (H2O2), and the chelating effect on Fe(II) were used. H2O2-induced cell death in HUVECs was determined with the MTT assay.ResultsENT (10 and 20 μM) scavenged 60% and 83% of DPPH activity, respectively. These percentages were greater than those resulting from using the same concentrations of vitamin C and vitamin E. ENT’s HOCl-scavenging activity was concentration-dependent and 8 to 20 times stronger than those of vitamin C and vitamin E. ENT’s ONOO−-scavenging activity was 8% to 30% stronger than that of vitamin C. However, ENT, vitamin C, and vitamin E were not able to directly scavenge H2O2, and did not show any chelating effect on Fe(II). Importantly ENT, but not vitamin C or vitamin E, inhibited H2O2-induced cell death in HUVECs.ConclusionsENT is an antioxidant that can scavenge toxic HOCl and ONOO− species and inhibit oxidative stress-induced cell death more effectively than vitamin C and vitamin E. ENT may have new clinical applications as an antioxidant in the treatment of ROS-induced diseases including cardiovascular disease, cancer, and neurodegenerative diseases.

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“…The TOS assay was calibrated using H 2 O 2 , and the results are presented as µM H 2 O 2 equivalent per liter. The automated TAC and TOS assays were performed using commercially available kits (n = 5) (Rel Assay, Gaziantep, Turkey) [21,22].…”

Section: Tac and Tos Analysismentioning

confidence: 99%

Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer’s Disease

et al. 2021

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So far, there is no effective disease-modifying therapies for Alzheimer’s Disease (AD) in clinical practice. In this context, glycine-L-proline-L-glutamate (GPE) and its analogs may open the way for developing a novel molecule for treating neurodegenerative disorders, including AD. In turn, this study was aimed to investigate the neuroprotective potentials exerted by three novel GPE peptidomimetics (GPE1, GPE2, and GPE3) using an in vitro AD model. Anti-Alzheimer potentials were determined using a wide array of techniques, such as measurements of mitochondrial viability (MTT) and lactate dehydrogenase (LDH) release assays, determination of acetylcholinesterase (AChE), α-secretase and β-secretase activities, comparisons of total antioxidant capacity (TAC) and total oxidative status (TOS) levels, flow cytometric and microscopic detection of apoptotic and necrotic neuronal death, and investigating gene expression responses via PCR arrays involving 64 critical genes related to 10 different pathways. Our analysis showed that GPE peptidomimetics modulate oxidative stress, ACh depletion, α-secretase inactivation, apoptotic, and necrotic cell death. In vitro results suggested that treatments with novel GPE analogs might be promising therapeutic agents for treatment and/or or prevention of AD.

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Zingiberene attenuates hydrogen peroxide-induced toxicity in neuronal cells

Cited by 20 publications

References 50 publications

Ginger and Turmeric Essential Oils for Weed Control and Food Crop Protection

Ginger and Turmeric Essential Oils for Weed Control and Food Crop Protection

Entacapone is an Antioxidant More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-Induced Cell Death

Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer’s Disease

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