Zingiberene exerts chemopreventive activity against 7,12‐dimethylbenz(a)anthracene‐induced breast cancer in Sprague‐Dawley rats

Abstract

Breast cancer is the primary cause of cancer-related death in females, wherein increased mortality of breast cancer patients is recorded worldwide. Zingiberene is a monocyclic sesquiterpene from the ginger plant and has many pharmacological benefits. In this exploration, we assessed the anticancer actions of Zingiberene against the 7,12-dimethylbenz(a)anthracene (DMBA)-stimulated mammary carcinogenesis in rats and MDA-MB-231 cells. Breast cancer was induced in the Female Sprague-Dawley rats through the 25 mg/kg of DMBA in 0.5 ml of corn oil and then treated with 20 and 40 mg/kg of Zingiberene, respectively. The body weight of animals and tumor volume was measured. Hematological parameters, transaminases, lipid profile, lipid peroxidation, and antioxidants status were scrutinized using standard techniques. The estrogen receptor-α and inflammatory markers were inspected by using respective assay kits. Histological damage scores were determined. In vitro experiments were conducted to scrutinize Zingiberene's effect on cell viability and apoptotic cell death in MDA-MB-231 cells. Zingiberene substantially modulated the DMBA-stimulated physiological and hematological changes and decreased the transaminases, and lipid peroxidation in the DMBAstimulated animals. Zingiberene also elevated the antioxidant level and suppressed the inflammatory markers. Histological study revealed the protective effects of Zingiberene. The viability of MDA-MB-231 cells was noticeably diminished by the Zingiberene, thus inducing apoptotic cell death. Overall, our findings reliably proved the anticancer potential of Zingiberene against the DMBA-stimulated mammary tumorigenesis, and it could be a promising chemotherapeutic agent.

Zingiberene attenuates paclitaxel-induced ototoxicity by strengthening cochlear antioxidant defense system in vivo

“…Our study aimed to determine whether ZBN, a powerful antioxidant, would have an otoprotective effect against PCX-induced ototoxicity. ZBN is a major component of Zingiber officinale and is a monocyclic sesquiterpene with essential medicinal properties including antioxidant [14], antibacterial [32], and antiviral [33], antiulcer [34], and anticancer [16,[35][36][37]. ZBN effectively decreased angiogenesis and inflammatory response, according to a recent study [38].…”

Redox-Sensitive Poly(lactic-co-glycolic acid) Nanoparticles of Palbociclib: Development, Ultrasound/Photoacoustic Imaging, and Smart Breast Cancer Therapy

“…Next, a volume was calculated for each coronal slice using the software. Photoacoustic imaging with OxyHemo-Mode was utilized to assess the hypoxic volumes, and power Doppler was used for accessing the tumor vascularity. , …”

Research Trend and Detailed Insights into the Molecular Mechanisms of Food Bioactive Compounds against Cancer: A Comprehensive Review with Special Emphasis on Probiotics

“…This observation indicated the importance of the compound’s natural form, hinting that other natural components in ginger or any natural product may play essential roles in their overall activity [ 140 ]. Several phenolic compounds such as 6-gingerol, 6-shagol, zingerone, and 6-paradol have shown oncolytic effects in various experimental models [ 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 ]. Ginger extract inhibits breast tumor growth through the blockade of the G2/M phase.…”

“…Another study showed a significant reduction in breast tumor growth in the orthotopic model of mice due to treatment with zerumbone, a cyclic sesquiterpene in ginger [ 152 ]. Seshadri et al found that zingiberene, a constituent of ginger, inhibited the 7,12-dimethylbenz(a)anthracene-induced breast cancer growth in Sprague–Dawley rats [ 151 ]. Zerumbone and 6-shogaol treatment arrested the growth of prostate cancer cells (DU-145) in the G1 phase.…”