Zirconium-Based Metal–Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Wang, Hung Li; Yeh, Hsin Chih; Li, Bin Han; Lin, Chia Her; Hsiao, Ta-Chih; Tsai, De‐Hao

doi:10.1021/acsanm.9b00834

Cited by 37 publications

(34 citation statements)

References 31 publications

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“…The stability of MOF is relatively weak under a variety of conditions, including low pH which can lead to the protonation of the imidazole ligand ( Li et al, 2017 ) or rigid carboxylate ligands, various ions (MgCl 2 or NaCl-containing Tris-HCl buffer ( Zhang et al, 2014b ), PO 4 3− ( Wang et al, 2019a )) due to the anion exchange ( Velasquez-Hernandez et al, 2019 ), which leads to the break of the coordination bond and the destruction of the MOF structure, further limiting its sensing applications. Now, only a limited MOF has good water stability ( Qiu et al, 2019 ): (1) the metal carboxylate frameworks composed of high-valence metal ions (such as Cr 3+ , Fe 3+ , and Zr 4+ ) which provide high coordination number and charge density, including MIL-101(Cr), MIL-100 (Fe), UiO-66(Zr), and PCN family; (2) the metal azolate frameworks composed of soft nitrogen-donor ligands (such as imidazolates, tetrazolates, triazolates, and pyrazolates).…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“…In addition, Pt modified electrodes have also been widely explored for the detection of hydrogen, and other gases like oxygen and ammonia in recent years. [5][6][7][8] MOFs are a new class of functional porous materials with inorganic and organic species arranged in a regular pattern [9][10][11][12] . The inorganic component in MOFs is usually a metal or metal oxide node, and the organic part is a multidentate ligand such as a benzene carboxylic acid.…”

Section: Introductionmentioning

confidence: 99%

Electrodeposited Metal Organic Framework toward Excellent Hydrogen Sensing in an Ionic Liquid

Azhar

Hussain

Tadé

et al. 2020

ACS Appl. Nano Mater.

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The synthesis of thin films of metal organic frameworks (MOFs) is a rapidly growing area owing to the use of these highly functional nanomaterials for various applications. In this study, a thin layer of a typical MOF, copper benzene tricarboxylate (HKUST-1), was synthesized by electrodeposition on a glassy carbon (GC) electrode using a potential-step chronoamperometric technique at room temperature. Various characterization techniques including Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) were used to verify the successful deposition of the MOF film and its structure. The electrodeposited MOF crystals showed cuboctahedral morphology with macropores. The MOF-modified electrode was applied for hydrogen gas sensing in a room temperature ionic liquid (RTIL) for the first time.A four-fold increase in current was observed compared to a precious metal surface, i.e. platinum, and the electrode exhibited significant catalytic activity compared to the bare GC electrode, making it a very promising low cost material for hydrogen gas sensing applications.

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“…To increase the biological functionality and biocompatibility functionalization of MOFs with biomolecules such as nucleobases, saccharides, peptides, and amino acids have been employed as the organic ligands to prepare bio-MOFs. Zirconium-based MOF was prepared as a nanocarrier for the controlled release of ibuprofen in an acidic phosphate buffer solution [ 226 ]. Horcajada and collaborators reported the use of a series of non-toxic porous iron (III)-based nanoMOFs [ 227 ], i.e., MIL-53, MIL-88A, MIL-88Bt, MIL-89, MIL-100 and MIL-101-NH 2 , as carriers of antineoplastic and retroviral drugs, including busulfan, azidothymidine triphosphate, doxorubicin or cidofovir, ibuprofen, etc.…”

Section: Various Metallic Nanocarriers In Drug Delivery Systemsmentioning

confidence: 99%

Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems

2022

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Over the past few years, nanotechnology has been attracting considerable research attention because of their outstanding mechanical, electromagnetic and optical properties. Nanotechnology is an interdisciplinary field comprising nanomaterials, nanoelectronics, and nanobiotechnology, as three areas which extensively overlap. The application of metal nanoparticles (MNPs) has drawn much attention offering significant advances, especially in the field of medicine by increasing the therapeutic index of drugs through site specificity preventing multidrug resistance and delivering therapeutic agents efficiently. Apart from drug delivery, some other applications of MNPs in medicine are also well known such as in vivo and in vitro diagnostics and production of enhanced biocompatible materials and nutraceuticals. The use of metallic nanoparticles for drug delivery systems has significant advantages, such as increased stability and half-life of drug carrier in circulation, required biodistribution, and passive or active targeting into the required target site. Green synthesis of MNPs is an emerging area in the field of bionanotechnology and provides economic and environmental benefits as an alternative to chemical and physical methods. Therefore, this review aims to provide up-to-date insights on the current challenges and perspectives of MNPs in drug delivery systems. The present review was mainly focused on the greener methods of metallic nanocarrier preparations and its surface modifications, applications of different MNPs like silver, gold, platinum, palladium, copper, zinc oxide, metal sulfide and nanometal organic frameworks in drug delivery systems.

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Zirconium-Based Metal–Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Cited by 37 publications

References 31 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Electrodeposited Metal Organic Framework toward Excellent Hydrogen Sensing in an Ionic Liquid

Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems

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