Zmiany w stężeniu greliny, CCK, GLP-1 i ekspresji receptorów aktywowanych przez proliferatory peroksysomów w szczurzym modelu anoreksji wywołanej przez hipoksję

Duraisamy, Arul J.; Bayen, Susovan; Saini, Supriya; Sharma, Alpesh K.; Vats, Praveen; Singh, Shashi Bala

doi:10.5603/ep.2015.0043

Cited by 17 publications

(5 citation statements)

References 30 publications

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“…Some studies revealed that changes in ghrelin and CCK were supposedly responsible for anorexia at high altitude, [ 28 , 29 ] whereas others were identified decreased or unaffected satiety hormones during hypoxic exposure. [ 30 , 31 ] The current results indicated a decrease in CCK levels in the LLTL but not the LHTL group, thereby indicating a reduced satiety after LLTL intervention. Based on the background that leptin and insulin are elevated in obesity and differently affected by hypoxia and aerobic exercise, [ 32 – 34 ] we may speculate that the effect of aerobic exercise and hypoxia on leptin and insulin regulation is benign and the changes are accompanied by weight loss.…”

Section: Discussionmentioning

confidence: 55%

“Living High-Training Low” improved weight loss and glucagon-like peptide-1 level in a 4-week weight loss program in adolescents with obesity

et al. 2018

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Background:“Living High-Training Low” (LHTL) is effective for the improvement of athletic ability; however, little is known about the effect of LHTL on obese individuals. The present study determined whether LHTL would have favorable influence on body composition, rebalance the appetite hormones, and explore the underlying mechanism.Methods:Adolescents with obesity [body mass index (BMI) >30 kg/m2] were randomly assigned to “Living Low-Training Low” (LLTL, n = 19) group that slept in a normobaric normoxia condition and the LHTL (n = 16) group slept in a normobaric hypoxia room (14.7% PO2 ∼2700 m). Both groups underwent the same aerobic exercise training program. Morphological, blood lipids, and appetite hormones were measured and assessed.Results:After the intervention, the body composition improved in both groups, whereas reductions in body weight (BW), BMI, and lean body mass increased significantly in the LHTL group (all, P < .05). In the LLTL group, cholecystokinin (CCK) decreased remarkably (P < .05) and CCK changes were positively associated with changes in BW (r = 0.585, P = .011) and BMI (r = 0.587, P = .010). However, in the LHTL group, changes in plasma glucagon-like peptide-1 (GLP-1) and interleukin-6 (IL-6) levels, positively correlated with each other (r = 0.708, P = .015) but negatively with BW changes (r = −0.608, P = .027 and r = −0.518, P = .048, respectively).Conclusion:The results indicated that LHTL could induce more weight loss safely and efficiently as compared to LLTL and increase the plasma GLP-1 levels that may be mediated by IL-6 to rebalance the appetite. Thus, an efficient method to treat obesity and prevent weight regain by appetite rebalance in hypoxia condition was established.

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Section: Discussionmentioning

confidence: 55%

“Living High-Training Low” improved weight loss and glucagon-like peptide-1 level in a 4-week weight loss program in adolescents with obesity

et al. 2018

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“…Woolcott in their study showed that living at high altitude (1,500–3,500 m) is associated with a lower likelihood of having diabetes than living between 0 and 499 m in the same way those living at high altitude were 25% less likely to be obese ( Woolcott et al, 2014 ). Several hypothesis have been raised about weight loss at high altitude, including those briefly discussed above (increased resting metabolic rate), as well as the possible role of endocrine molecules such as neuropeptide Y (NPY), ghrelin, galanin, cholecystokinin (CCK), and interleukin-6 (IL-6) stimulating weight loss ( Duraisamy et al, 2015 ). In addition, the negative energy balance in hypoxia seems to be largely due to a reduction in energy intake due to lack of appetite and probably due to a reduced carbohydrate and lipids intake ( Díaz-Gutiérrez et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Stroke-Related Mortality at Different Altitudes: A 17-Year Nationwide Population-Based Analysis From Ecuador

et al. 2021

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Introduction: Worldwide, more than 5.7% of the population reside above 1,500 m of elevation. It has been hypothesized that acute short-term hypoxia exposure could increase the risk of developing a stroke. Studies assessing the effect of altitude on stroke have provided conflicting results, some analyses suggest that long-term chronic exposure could be associated with reduced mortality and lower stroke incidence rates.Methods: An ecological analysis of all stroke hospital admissions, mortality rates, and disability-adjusted life years in Ecuador was performed from 2001 to 2017. The cases and population at risk were categorized in low (<1,500 m), moderate (1,500–2,500 m), high (2,500–3,500 m), and very high altitude (3,500–5,500 m) according to the place of residence. The derived crude and direct standardized age-sex adjusted mortality and hospital admission rates were calculated.Results: A total of 38,201 deaths and 75,893 stroke-related hospital admissions were reported. High altitude populations (HAP) had lower stroke mortality in men [OR: 0.91 (0.88–0.95)] and women [OR: 0.83 (0.79–0.86)]. In addition, HAP had a significant lower risk of getting admitted to the hospital when compared with the low altitude group in men [OR: 0.55 (CI 95% 0.54–0.56)] and women [OR: 0.65 (CI 95% 0.64–0.66)].Conclusion: This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has a stronger effect between 2,000 and 3,500 m.

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“…Considering the critical role of GLP-1 in energy metabolism and inflammation, we investigated the underlying mechanisms of GLP-1 suppression in the HTH environment. High relative humidity reduces the ambient oxygen concentration in the air, and hypoxia inhibits GLP-1 production in vivo 8 . We wondered whether the increase in gut hypoxia caused GLP-1 suppression.…”

Section: Resultsmentioning

confidence: 99%

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

Chen,

Hu,

Tang

et al. 2024

Commun Biol

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High temperature and humidity in the environment are known to be associated with discomfort and disease, yet the underlying mechanisms remain unclear. We observed a decrease in plasma glucagon-like peptide-1 levels in response to high-temperature and humidity conditions. Through 16S rRNA gene sequencing, alterations in the gut microbiota composition were identified following exposure to high temperature and humidity conditions. Notably, changes in the gut microbiota have been implicated in bile acid synthesis. Further analysis revealed a decrease in lithocholic acid levels in high-temperature and humidity conditions. Subsequent in vitro experiments demonstrated that lithocholic acid increases glucagon-like peptide-1 secretion in NCI-H716 cells. Proteomic analysis indicated upregulation of farnesoid X receptor expression in the ileum. In vitro experiments revealed that the combination of lithocholic acid with farnesoid X receptor inhibitors resulted in a significant increase in GLP-1 levels compared to lithocholic acid alone. In this study, we elucidate the mechanism by which reduced lithocholic acid suppresses glucagon-like peptide 1 via farnesoid X receptor activation under high-temperature and humidity condition.

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Zmiany w stężeniu greliny, CCK, GLP-1 i ekspresji receptorów aktywowanych przez proliferatory peroksysomów w szczurzym modelu anoreksji wywołanej przez hipoksję

Cited by 17 publications

References 30 publications

“Living High-Training Low” improved weight loss and glucagon-like peptide-1 level in a 4-week weight loss program in adolescents with obesity

“Living High-Training Low” improved weight loss and glucagon-like peptide-1 level in a 4-week weight loss program in adolescents with obesity

Stroke-Related Mortality at Different Altitudes: A 17-Year Nationwide Population-Based Analysis From Ecuador

High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice

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