Zn and Cu Content in Human Cancellous Bone

Lappalainen, R; Knuuttila, Matti; Lammi, Seppo; Alhava, Esko; Olkkonen, H.

doi:10.3109/17453678208992178

Cited by 38 publications

(14 citation statements)

References 25 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6a). This is in agreement with prior investigations of Lappalainen et al, who showed that Ca is not a significant factor for explaining the Zn concentrations in bone [82]. Therefore Zn is suggested to be under homeostatic control.…”

Section: Discussionsupporting

confidence: 93%

Spatial distribution of the trace elements zinc, strontium and lead in human bone tissue

Pemmer

Roschger

Wastl

et al. 2013

Bone

156

111

View full text Add to dashboard Cite

Trace elements are chemical elements in minute quantities, which are known to accumulate in the bone. Cortical and trabecular bones consist of bone structural units (BSUs) such as osteons and bone packets of different mineral content and are separated by cement lines. Previous studies investigating trace elements in bone lacked resolution and therefore very little is known about the local concentration of zinc (Zn), strontium (Sr) and lead (Pb) in BSUs of human bone. We used synchrotron radiation induced micro X-ray fluorescence analysis (SR μ-XRF) in combination with quantitative backscattered electron imaging (qBEI) to determine the distribution and accumulation of Zn, Sr, and Pb in human bone tissue.Fourteen human bone samples (10 femoral necks and 4 femoral heads) from individuals with osteoporotic femoral neck fractures as well as from healthy individuals were analyzed. Fluorescence intensity maps were matched with BE images and correlated with calcium (Ca) content. We found that Zn and Pb had significantly increased levels in the cement lines of all samples compared to the surrounding mineralized bone matrix. Pb and Sr levels were found to be correlated with the degree of mineralization. Interestingly, Zn intensities had no correlation with Ca levels. We have shown for the first time that there is a differential accumulation of the trace elements Zn, Pb and Sr in BSUs of human bone indicating different mechanisms of accumulation.

show abstract

Section: Discussionsupporting

confidence: 93%

Spatial distribution of the trace elements zinc, strontium and lead in human bone tissue

Pemmer

Roschger

Wastl

et al. 2013

Bone

156

111

View full text Add to dashboard Cite

show abstract

“…The role of zinc and copper in chronic inflammatory diseases is of interest because they are co-factors of important enzymes involved in collagen and bone metabolism [1,2], immune system function [3,4] and antioxidant protection [5].…”

Section: Introductionmentioning

confidence: 99%

Serum zinc and copper in active rheumatoid arthritis: Correlation with interleukin 1? and tumour necrosis factor ?

et al. 1998

View full text Add to dashboard Cite

Serum zinc and copper levels and serum interleukin 1 beta (IL1 beta) and tumour necrosis factor alpha (TNF alpha) levels were evaluated in 57 female patients with active rheumatoid arthritis (RA) to investigate a possible role of IL1 beta and TNF alpha on zinc and copper homeostasis in RA. Serum zinc levels were significantly lower and serum copper levels significantly higher in RA patients when compared with osteoarthritis or asymmetrical psoriatic oligoarthritis patients and with normal controls. No differences were observed in serum IgM rheumatoid factor positive and serum IgM rheumatoid factor negative patients as regards serum zinc and copper concentration. In RA patients the erythrocyte sedimentation rate and acute-phase proteins correlated negatively with serum zinc and positively with serum copper. IL1 beta and TNF alpha were found to correlate negatively with zinc and positively with copper in RA patients. Lower levels of zinc may be due to an accumulation of zinc-containing proteins in the liver and in the inflamed joints in RA. Elevated serum copper levels seem to be linked to the increased synthesis of ceruloplasmin by the liver.

show abstract

“…Zn also supports metabolism and growth of bone, increases bone density, and inhibits bone loss [37, 38]. Zinc, also involved in bonding with organic structure [26]. Our study shows that the deficiency of zinc was found in the osteoporosis bone.…”

Section: Discussionmentioning

confidence: 56%

“…Copper makes a crosslink with collagen. Copper was antagonist for zinc in bone, which means that increasing copper induces decreasing zinc level [26]. Copper deficiency decreases osteoblast activity and induces osteoporosis [27].…”

Section: Discussionmentioning

confidence: 99%

Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry

Noor

Sumitro

Hidayat

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

Clinical research indicates that negative calcium balance is associated with low bone mass, rapid bone loss, and high fracture rates. However, some studies revealed that not only calcium is involved in bone strengthening as risk factor of fracture osteoporosis. Thus, in this report, the difference of metallic and nonmetallic elements in osteoporosis and normal bones was studied by high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS). The influence of these elements on bone metabolic processes is also discussed. Inclusion criteria of bone samples consist of postmenopausal woman, trabecular bone fracture, normal and osteoporosis BMD value, and no history of previous disease. The results showed that the concentration of B, Al, S, V, Co, Mo, Te, Ba, La, Ni, As, and Ca/P ratio is higher in osteoporosis than normal. These atomic minerals have negative role to imbalance between bone resorption and bone formation activity. Conversely, concentrations of Na, Mg, P, K, Ca, Cr, Pd, Ag, Mn, Fe, Cu, Zn, Rb, Sr, Pb, and Se are lower in osteoporosis than in normal bones. Among these atoms, known to have important roles in bone structure, we found involvement of atomic mineral and calcium which are considerable to contribute to osteoporotic phenomena.

show abstract

Zn and Cu Content in Human Cancellous Bone

Cited by 38 publications

References 25 publications

Spatial distribution of the trace elements zinc, strontium and lead in human bone tissue

Spatial distribution of the trace elements zinc, strontium and lead in human bone tissue

Serum zinc and copper in active rheumatoid arthritis: Correlation with interleukin 1? and tumour necrosis factor ?

Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry

Contact Info

Product

Resources

About