Zn-Coordinated Lipid Nanocapsules with High Physical Stability and Water-Responsive Morphological Change

Ding, Wuxiao; Aoyagi, Masaru; Masuda, Mitsutoshi; Kogiso, Masaki

doi:10.5650/jos.ess16132

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…Please note that the nanotubes transformed from nanovesicles in ethanol lack coordinated water (Figure S2). In our previous report, nanovesicles also transformed into nanotubes by the coordination with two water molecules when dispersed in an ethanol–water mixture (1:1 of volume ratio). Therefore, in the present case of ethanol, transformation of nanovesicles into nanotubes shall occur in a different mechanism other than the coordination with water.…”

Section: Resultsmentioning

confidence: 84%

“…Although those morphologies were confirmed in the dry state, those morphologies have high stability composed of solid bilayer membranes, and they shall also exist in the ethanol dispersions. 35,36,38 On the basis of the results of M-GG and P-GG (Figures 4 and 5), nanovesicles can be considered as semistable intermediate structures while nanotubes as the thermodynamically stable structures. Among the three lipids, M-GG was the most suitable one for the selective preparation of nanovesicles in ethanol at 20 °C, L-GG with a higher solubility and quick formation of complexes preferred the direct formation of nanotubes, and P-GG with a lower solubility could restrain the formation of complexes and gave a mixture of nanovesicles and nanotubes.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Supramolecular coordination has been a well-known methodology for the fabrication of stable nanocapsules such as molecular cages, ,, metal-coordinated nanotubes, − and rare metal-containing nanovesicles. − We previously reported biocompatible lipid nanovesicles that contain solid bilayer membranes via the supramolecular coordination of a zinc ion with glycylglycine lipid (M-GG in Figure ). The solid bilayer membranes and metal coordination conferred the nanovesicles with high physical stability in a dry state. Interestingly, the nanovesicles showed a morphological change into nanotubes when redispersed in water, enabling their potential applications in drug formulation and related fields.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Formation Process of Zn(II)-Coordinated Nanovesicles

et al. 2017

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Mixing a glycylglycine lipid and zinc acetate has been reported to form novel supramolecular Zn(II)-coordinated nanovesicles in ethanol. In this study, we investigate in detail the formation of nanovesicles by using three lipids at different temperatures and discuss their formation process. The original lipids show extremely low solubilities and appear as plate structures in ethanol. Within a small window of lipid solubility, the formation of lipid-Zn(II) complexes occurs mainly on the solid surfaces of plate structures. Controlling of the lipid solubility by temperature affects the kinetics of complex formation and the subsequent transformation of the complexes into nanovesicles and nanotubes. An improved method of two-step control of temperature is developed for preparing all the three kinds of nanovesicles. We provide new insights into the formation process of nanovesicles based on several control experiments. A tetrahedral lipid-cobalt(II) complex similarly produces nanovesicles, whereas an octahedral complex gives sheet structures. Mixing of zinc acetate with a β-alanyl-β-alanine lipid can only give sheet structures, which lack a polyglycine II hydrogen-bond network and induce no morphological changes. We conclude that the formation of the lipid-Zn(II) complexes on solid plate structures, tetrahedral geometry, and polyglycine II hydrogen-bond network in the complexes shall work cooperatively for the formation of Zn(II)-coordinated nanovesicles.

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Section: Resultsmentioning

confidence: 84%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and Formation Process of Zn(II)-Coordinated Nanovesicles

et al. 2017

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“…5b). 19,20 Fig. 5d shows the transmission electron microscopy image of as-prepared nanovesicles mixed with 5 wt% polyoxyethylene sorbitan monolaurate (Tween 20).…”

Section: Resultsmentioning

confidence: 99%

Humidity control in a closed system utilizing conducting polymers

et al. 2018

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“…This nanocapsule can encapsulate molecules such as methylene blue inside its hollow space, if the molecules were dissolved in ethanol in advance. We briefly reported this result in the rapid paper [13]. In this paper, we present recent development of mass production method and detailed characters about the organic nanocapsule.…”

Section: Introductionmentioning

confidence: 94%

Mass-Producible Organic Nanocapsule with Water-Responsive Releasing Ability

Kogiso

Ding

Masuda

2018

MSF

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An organic nanocapsule was obtained by mixing zinc acetate powder into a peptide lipid dispersion in ethanol. The nanocapsule was mass-produced at a scale of over 100 g L–1 within 1 h. Fourier transform infrared spectroscopy and scanning electron microscopy revealed that a zinc-peptide lipid complex was formed within 15 min, which subsequently transformed into a nanocapsule as a result of changes in the hydrogen bonding networks between the peptides. A variety of organic dyes could be encapsulated by simply adding them during the nanocapsule formation. We also confirmed their high stabilities in organic solvents, water-responsive morphological change, and resulting guest release. The water-responsive nanocapsule is expected to be useful in a variety of fields.

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Zn-Coordinated Lipid Nanocapsules with High Physical Stability and Water-Responsive Morphological Change

Cited by 9 publications

References 30 publications

Preparation and Formation Process of Zn(II)-Coordinated Nanovesicles

Preparation and Formation Process of Zn(II)-Coordinated Nanovesicles

Humidity control in a closed system utilizing conducting polymers

Mass-Producible Organic Nanocapsule with Water-Responsive Releasing Ability

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