Zn(II)–curcumin protects against oxidative stress, deleterious changes in sperm parameters and histological alterations in a male mouse model of cyclophosphamide-induced reproductive damage

Lü, Wenping; X, Mei; Wang, Yu; Zheng, Yanping; Xue, Yunfei; Xu, Donghui

doi:10.1016/j.etap.2014.12.014

Cited by 52 publications

(36 citation statements)

References 54 publications

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“…[222324] The consistent findings of the present study and other research on the sperm motility and viability may be explained by the cyclophosphamide antioxidant property and decreased serum levels of luteinizing hormone, follicle stimulating hormone, and testosterone.…”

Section: Discussionsupporting

confidence: 88%

“…[19] Other studies also indicated that use of cyclophosphamide low doses in the long-term can decrease the weights of body and reproductive organs in male rats, cause atrophy in certain organs such as testicles and epididymis, and hence affect fertility rate. [151920212223]…”

Section: Discussionmentioning

confidence: 99%

“…[1922232425] The sperm cells capability of moving is considered a decisive and important factor for fertility and can ensure the process of insemination. The sperm motility is likely to decline when free radicals and the final products of lipids peroxidation increase in the culture medium.…”

Section: Discussionmentioning

confidence: 99%

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The effects of Vitamin C on sperm quality parameters in laboratory rats following long-term exposure to cyclophosphamide

Shabanian

Farahbod

Mahmoud

et al. 2017

J Adv Pharm Technol Res

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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The effects of Vitamin C on sperm quality parameters in laboratory rats following long-term exposure to cyclophosphamide

Shabanian

Farahbod

Mahmoud

et al. 2017

J Adv Pharm Technol Res

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“…The drugs dosage was obtained from the previous studies (Lu et al, 2015;Obay, Taşdemir, Tümer, Bilgin, & Atmaca, 2008). Animals were prepared from the animals' house of Tabriz Medical University and were kept under standard conditions (temperature 22-24°C with the light/dark cycle of 12 hrs).…”

Section: Animals and Study Designmentioning

confidence: 99%

“…Studies on animals show that treatment of male mice with CP results in damage to DNA, testis weight loss, oligospermia, and histological and biochemical changes in the testis and epididymis (Lu et al, 2015;Manda & Bhatia, 2003). However, based on the results of numerous studies, the administration of CP can impair the balance of free radicals in tissues and thus results in biochemical and physiological disorders caused by oxidative stress Lu et al, 2015). On the other hand, it is reported that the sensitivity of the post-meiotic cells to CP specifically is greater than other sexual cells (Hales et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide

et al. 2017

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Cyclophosphamide is a drug used for chemotherapy and as an immune-suppressive in the organ transplantation. Despite its many clinical implications in the treatment of cancers, this drug has toxic effects on the reproductive system. This study aimed to evaluate the effect of ghrelin against the damages caused by cyclophosphamide. In this experimental study, 40 male mice were randomly divided into four groups: (i) control; (ii) cyclophosphamide; (iii) cyclophosphamide + ghrelin; and (iv) ghrelin. Cyclophosphamide (100 mg/kg body weight), once a week, and ghrelin (80 μg/kg body weight), daily, were administered intraperitoneally for 5 weeks. After 5 weeks, the epididymides were removed and the lipid peroxidation, total antioxidant capacity and sperm parameters were examined. The fertility rate was evaluated by performance in vitro fertilisation. In the mice exposed to cyclophosphamide, the number of spermatozoa and viability, as well as total antioxidant capacity, decreased significantly (p < .05). The increase in the abnormal sperm and MDA levels was observed (p < .05). In addition, the fertility rate decreased in this group, while the use of ghrelin significantly improved the above disorders in the treatment group (p < .05). The findings of this study showed that ghrelin attenuates negative effects caused by cyclophosphamide in the sperm parameters and enhances the fertility.

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Huangqi‐Guizhi‐Wuwutang protects against oligospermia in mice by promoting the proliferation of spermatogenic stem cells: A comprehensive study using HPLC‐Q‐TOF/MS and experimental pharmacology

Zhao,

Wu,

et al. 2024

Biomedical Chromatography

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The classical traditional Chinese medicine formula Huangqi‐Guizhi‐Wuwutang (HGW) has been shown to enhance sperm production. However, the bioactive components and comprehensive mechanisms underlying the therapeutic effects remain unclear. The present study investigates the potential active ingredients and underlying mechanisms of HGW against spermatogenesis dysfunction. The chemical components of HGW were analyzed by mass spectrometry. And then the “components‐targets‐pathway‐disease” network was constructed using network pharmacology research methods, which aimed to identify the key active components and potential targets of HGW in treating oligospermia. Experimental validation was finally conducted in animal model. The male‐specific pathogen‐free Kunming mice were divided into five groups: Sham group, Model group, and HGW groups (8, 16, and 32 g/kg of HGW by gavage for 35 days). Chemical profile and network pharmacology results revealed that potential bioactive compounds were dihydrocinnacasside, isomucronulatol, and 6‐gingerol, and the mechanism of which was enriched in regulating spermatogenic stem cells (SSCs), endocrine function, and apoptosis. The administration of HGW significantly improved oligospermia in mice. HGW significantly upregulated the expression of marker proteins in SSCs and the potential targets within the testis simultaneously. Our data indicates that HGW enhances the proliferation of SSCs, and HGW can be a promising therapeutic candidate for oligospermia.

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Zn(II)–curcumin protects against oxidative stress, deleterious changes in sperm parameters and histological alterations in a male mouse model of cyclophosphamide-induced reproductive damage

Cited by 52 publications

References 54 publications

The effects of Vitamin C on sperm quality parameters in laboratory rats following long-term exposure to cyclophosphamide

The effects of Vitamin C on sperm quality parameters in laboratory rats following long-term exposure to cyclophosphamide

Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide

Huangqi‐Guizhi‐Wuwutang protects against oligospermia in mice by promoting the proliferation of spermatogenic stem cells: A comprehensive study using HPLC‐Q‐TOF/MS and experimental pharmacology

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