Zn(II) detection in biological samples with a smart sensory polymer

Guembe-García, Marta; Vallejos, Saúl; Carreira-Barral, Israel; Ibeas, Saturnino; García, Félix C.; Santaolalla-García, Victoria; Moradillo-Renuncio, Natalia; García, José Miguel

doi:10.1016/j.reactfunctpolym.2020.104685

Cited by 7 publications

(5 citation statements)

References 61 publications

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“…Polymer science can be the effective solution to overcome some of fluorogenic peptide substrates drawbacks: 1) Regarding stability, VP was selected as the main monomer for the polymer synthesis, because the derived co-polymers are highly hydrophilic, non-fluorescent 26 , and have previously demonstrated protective effects toward sensitive chemical groups without the need of including spacers 27 – 35 ; 2) regarding water solubility, we have previously described the preparation of polymers in 100% aqueous media in several publications 36 – 39 . These polymers contain a small proportion of receptor monomers originally water-insoluble (mol% < 1%).…”

Section: Introductionmentioning

confidence: 99%

The role of polymeric chains as a protective environment for improving the stability and efficiency of fluorogenic peptide substrates

Arnáiz

Guembe-García

Delgado‐Pinar

et al. 2022

Sci Rep

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We have faced the preparation of fully water-soluble fluorescent peptide substrate with long-term environmental stability (in solution more than 35 weeks) and, accordingly, with stable results in the use of this probe in determining the activity of enzymes. We have achieved this goal by preparing a co-polymer of the commercial N-vinyl-2-pyrrolidone (99.5% mol) and a fluorescent substrate for trypsin activity determination having a vinylic group (0.5%). The activity of trypsin has been measured in water solutions of this polymer over time, contrasted against the activity of both the commercial substrate Z-L-Arg-7-amido-4-methylcoumarin hydrochloride and its monomeric derivative, prepared ad-hoc. Initially, the activity of the sensory polymer was 74.53 ± 1.72 nmol/min/mg of enzyme, while that of the commercial substrate was 20.44 ± 0.65 nmol/min/mg of enzyme, the former maintained stable along weeks and the latter with a deep decay to zero in three weeks. The ‘protection’ effect exerted by the polymer chain has been studied by solvation studies by UV–Vis spectroscopy, steady-state & time resolved fluorescence, thermogravimetry and isothermal titration calorimetry.

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Section: Introductionmentioning

confidence: 99%

The role of polymeric chains as a protective environment for improving the stability and efficiency of fluorogenic peptide substrates

Arnáiz

Guembe-García

Delgado‐Pinar

et al. 2022

Sci Rep

Self Cite

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“…Peroxide is used to oxidize the conductive polymer in the last stage. 90,91 When a polymer is electrochemically oxidized in the presence of Na+, its conductivity decreases. The effect is most likely owing to the greater inductive activity of macrocyclic oxygens.…”

Section: Conducting Polymersmentioning

confidence: 99%

Review—Recent Progress, Challenges, and Trends in Polymer-Based Wearable Sensors

Saxena,

Shukla

2024

J. Electrochem. Soc.

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Wearable sensors offer a non-invasive, continuous, and personalized approach to monitor various physiological and environmental parameters. Among the various materials used in the fabrication of wearable sensors, polymers have gained significant attention due to their versatile properties, low cost, and ease of integration. We present a comprehensive review of recent advances and challenges in the development of polymer-based wearable sensors. We begin by highlighting the key characteristics of wearable sensors, emphasizing their potential applications and advantages. Subsequently, we delve into the various types of polymers employed for sensor fabrication, such as conductive polymers, elastomers, and hydrogels. The unique properties of each polymer and its suitability for specific sensing applications are discussed in detail. We also address the challenges faced in the development of polymer-based wearable sensors and describes the mechanism of action in these kinds of wearable sensor-capable smart polymer systems. Contact lens-based, textile-based, patch-based, and tattoo-like designs are taken into consideration. Additionally, we paper discuss the performance of polymer-based sensors in real-world scenarios, highlighting their accuracy, sensitivity, and reliability when applied to healthcare monitoring, motion tracking, and environmental sensing. In conclusion, we provide valuable insights into the current state of polymer-based wearable sensors, their fabrication techniques, challenges, and potential applications

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“…The reaction of the reduced enzyme and oxygen in the solution phase produces GOxFAD and H 2 O 2 . In the last step, the conductive polymer is oxidized by peroxide [ 59 , 60 ]. The conductivity of the polymer reduces when it is electrochemically oxidized in the presence of Na + .…”

Section: Synthetic Polymer-based Sensorsmentioning

confidence: 99%

Recent Progress, Challenges, and Trends in Polymer-Based Sensors: A Review

et al. 2022

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Polymers are long-chain, highly molecular weight molecules containing large numbers of repeating units within their backbone derived from the product of polymerization of monomeric units. The materials exhibit unique properties based on the types of bonds that exist within their structures. Among these, some behave as rubbers because of their excellent bending ability, lightweight nature, and shape memory. Moreover, their tunable chemical, structural, and electrical properties make them promising candidates for their use as sensing materials. Polymer-based sensors are highly utilized in the current scenario in the public health sector and environment control due to their rapid detection, small size, high sensitivity, and suitability in atmospheric conditions. Therefore, the aim of this review article is to highlight the current progress in polymer-based sensors. More importantly, this review provides general trends and challenges in sensor technology based on polymer materials.

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Zn(II) detection in biological samples with a smart sensory polymer

Cited by 7 publications

References 61 publications

The role of polymeric chains as a protective environment for improving the stability and efficiency of fluorogenic peptide substrates

The role of polymeric chains as a protective environment for improving the stability and efficiency of fluorogenic peptide substrates

Review—Recent Progress, Challenges, and Trends in Polymer-Based Wearable Sensors

Recent Progress, Challenges, and Trends in Polymer-Based Sensors: A Review

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