Zn(OAc)2/podand catalyzed ring opening of epoxides by aromatic amines under solvent-free conditions

Abstract

A highly regioselective ring opening of epoxides with aromatic amines in the presence of a catalytic amount of Zn(OAc) 2 and a recently synthesized podand under solvent-free conditions is described. The yields of the amino alcohols are uniformly good and the recovered catalyst could be used in new attempts without any purification.

An Efficient Method for the Ring Opening of Epoxides with Aromatic Amines by Sb(III) Chloride under Microwave Irradiation

“…The structures of all pure products were confirmed by IR, 1 H NMR and compared with data obtained from authentic amino alcohols. [8][9][10][11]15,16 1 H NMR and compared with authentic samples. 9,11,15,16 b Isolated yields.…”

“…Recently, the use of catalysts to carry out these reactions under mild conditions has been developed. [4][5][6][7][8][9][10][11] However, there are still some limitations with these methods including the failure of deactivated aromatic amines and some sterically hindered aromatic amines to open the epoxides, the need for an excess of reagent, reactions at reflux temperatures and sluggish reactions. Therefore, it is desirable to develop improved catalysts for the activation of epoxides, which render them to be more susceptible to nucleophilic attack under mild conditions.…”