Zn–Sr-sintered true bone ceramics enhance bone repair and regeneration

Hu, Yingkun; Wang, Yi; Feng, Qin-Yu; Chen, Tianhong; Hao, Zhuowen; Zhang, Shuwei; Cai, Lin; Guo, Xiaodong; Li, Jing‐Feng

doi:10.1039/d3bm00030c

Cited by 10 publications

(8 citation statements)

References 41 publications

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“…It has been demonstrated that the presence of Zn enhances osteogenic differentiation, bone formation, and mineralization. Additionally, according to the literature, zinc stimulates the formation and mineralization of osteoblastic bone by activating aminoacyl‐tRNA synthetase, 40 which is the rate‐limiting enzyme in the protein synthesis translation process within cells, and directly stimulates cellular protein synthesis. Further, zinc particles have significant antibacterial potential.…”

Section: Resultsmentioning

confidence: 99%

Engineering antibacterial shrinkage‐free trinary PLGA‐based GBR membrane for bone regeneration

Doost,

Shokrolahi,

Shokrollahi

et al. 2024

Polymers for Advanced Techs

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The purpose of this study was preparation of a multilayer electrospun poly (lactic‐co‐glycolic acid) (PLGA)‐based guided bone regeneration (GBR) membrane with controlled shrinkage behavior and alveolar bone regeneration property. First, PLGA copolymer, and zinc‐doped hydroxyapatite (Zn‐HAp) particles were prepared and characterized using fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), proton nuclear magnetic resonance, and X‐ray diffraction analysis. Since the electrospun PLGA scaffolds showed about 80% shrinkage at physiological conditions (phosphate‐buffered saline, 37°C), the effect of factors such as fiber‐alignment, and additives including natural polymers such as gelatin and chitosan, and Zn‐HAp particles; as well as solution preparation method was investigated on the shrinkage ratio. The results showed that it is possible to eliminate the shrinkage of the scaffold in the physiological environment through appropriate design of a tri‐layer PLGA‐CHI/PLGA‐Gel/PLGA‐Gel‐ZnHAp membrane. The designed tri‐layer membrane demonstrated a bubble point smaller than 7 μm, and improved mechanical properties compared with the individual sub‐layer scaffolds. Additionally, it exhibited enhanced antibacterial activity when compared with a similar three‐layer membrane in which HAp was used instead of Zn‐HAp. This observation suggests a synergistic antibacterial effect resulting from the presence of both zinc ions in Zn‐HAp and chitosan . Osteogenic differentiation of adipose‐derived mesenchymal stem cells cultured on the optimal multilayer composite scaffold, was investigated using alkaline phosphatase and Alizarin red staining assays, and the results suggested that the scaffold could support osteogenic differentiation of the stem cells. The designed membrane was implanted in critical size (1 cm) mandibular defects in dogs, and bone regeneration was monitored by computed tomography. Defects treated with the GBR membrane, and the control group showed 69.31% and 44.63%, newly mineralized tissue, respectively, after 8 weeks post implantation. Based on our results, the engineered 3‐layer scaffold is a promising candidate as a GBR membrane for periodontal applications.

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Section: Resultsmentioning

confidence: 99%

Engineering antibacterial shrinkage‐free trinary PLGA‐based GBR membrane for bone regeneration

Doost,

Shokrolahi,

Shokrollahi

et al. 2024

Polymers for Advanced Techs

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“…Zn–Sr sintered TCP exhibited good osteogenic and antibacterial properties in vitro , as well as good osteointegration and bone growth in vivo . 196 TCP doped with Zn, Si, and Sr elements exhibited better angiogenic ability. 118 Therefore, Zn incorporation is a promising method to improve osteogenic, antibacterial, angiogenic, immunomodulatory, and mechanical properties of TCP.…”

Section: Application Of Zinc-based Biomaterials In Bone Repair and Re...mentioning

confidence: 95%

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Wen,

Wang,

Pei

et al. 2023

J. Mater. Chem. B

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“…While excessive strontium can induce apoptosis, 121,122 it is typically incorporated in low concentrations as an osteoinductive element, often synergistically with other ions like zinc, silver, and magnesium, to bolster angiogenesis and osteogenesis. [123][124][125] F I G U R E 5 (A) Representative H&E images of the bone defect 7, 14, and 28 days after applying GBR membranes (Col, Col-MgO200, and Col-MgO500). The asterisks represent membranes, WB stands for Woven Bone.…”

Section: Strontiummentioning

confidence: 99%

Ion incorporation into bone grafting materials

Zhao,

Ni,

Wei

et al. 2023

Periodontology 2000

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The use of biomaterials in regenerative medicine has expanded to treat various disorders caused by trauma or disease in orthopedics and dentistry. However, the treatment of large and complex bone defects presents a challenge, leading to a pressing need for optimized biomaterials for bone repair. Recent advances in chemical sciences have enabled the incorporation of therapeutic ions into bone grafts to enhance their performance. These ions, such as strontium (for bone regeneration/osteoporosis), copper (for angiogenesis), boron (for bone growth), iron (for chemotaxis), cobalt (for B12 synthesis), lithium (for osteogenesis/cementogenesis), silver (for antibacterial resistance), and magnesium (for bone and cartilage regeneration), among others (e.g., zinc, sodium, and silica), have been studied extensively. This review aims to provide a comprehensive overview of current knowledge and recent developments in ion incorporation into biomaterials for bone and periodontal tissue repair. It also discusses recently developed biomaterials from a basic design and clinical application perspective. Additionally, the review highlights the importance of precise ion introduction into biomaterials to address existing limitations and challenges in combination therapies. Future prospects and opportunities for the development and optimization of biomaterials for bone tissue engineering are emphasized.

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Zn–Sr-sintered true bone ceramics enhance bone repair and regeneration

Abstract: Bone defects are one of the toughest challenges faced by orthopedic surgeons worldwide, especially at critical sizes, which are caused by severe trauma, malignancy, or congenital disease. The ideal bone...

Cited by 10 publications

References 41 publications

Engineering antibacterial shrinkage‐free trinary PLGA‐based GBR membrane for bone regeneration

Engineering antibacterial shrinkage‐free trinary PLGA‐based GBR membrane for bone regeneration

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Ion incorporation into bone grafting materials

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