Zn2+ regulates human oxalate metabolism by manipulating oxalate decarboxylase to treat calcium oxalate stones

Glyoxal in Foods: Formation, Metabolism, Health Hazards, and Its Control Strategies

“…Oxalate is not easily oxidized and broken down in the body, and most of the oxalic acid will be excreted through the urine and a small portion of oxalic acid will meet calcium and zinc to produce calcium oxalate and zinc oxalate crystals, which will make urinary system stones. 53 Moreover, glyoxal can be converted to glycolaldehyde through the coordinated action of aldo-ketoreductase and NADPH, and glycolaldehyde can be further converted to ethylene glycol. A portion of the ethylene glycol is excreted in the urine, while the remainder is oxidatively metabolized in the liver by the enzyme ethanol dehydrogenase to oxalate, which is subsequently excreted in the urine.…”

“…Subsequently, glyoxalase II in the kidney catalyzed the hydrolysis of S -hydroxyacetylglutathione to glycolate, which will be further oxidized or reduced to form oxalate. Oxalate is not easily oxidized and broken down in the body, and most of the oxalic acid will be excreted through the urine and a small portion of oxalic acid will meet calcium and zinc to produce calcium oxalate and zinc oxalate crystals, which will make urinary system stones . Moreover, glyoxal can be converted to glycolaldehyde through the coordinated action of aldo-ketoreductase and NADPH, and glycolaldehyde can be further converted to ethylene glycol.…”

Recent Advances of Oxalate Decarboxylase: Biochemical Characteristics, Catalysis Mechanisms, and Gene Expression and Regulation

“…70,71 Wu et al found that Zn 2+ regulates human oxalate metabolism by manipulating oxalate decarboxylase to treat calcium oxalate stones and promoting Lactobacillus in the intestinal flora. 72 More interesting is that Human Embryonic Kidney 293 (HEK293) cells expressing OXDC are capable of degrading oxalate protect cells from oxidative damage and serve as a therapeutic option for prevention of CaOx stone disease. 73 5.2.…”

“…Lactic acid bacteria that heterologously express OXDC may be used as potential probiotics for degrading intestinal oxalate to prevent calcium oxalate (CaOx) stone (Figure ). − For example, Paul and his colleagues developed food-grade probiotic L. plantarum secreting OXDC using mobile genetic element Ll.LtrB and chromosomal integration, which is capable of degrading intestinal oxalate and preventing CaOx stone formation in experimental rats. , Wu et al found that Zn 2+ regulates human oxalate metabolism by manipulating oxalate decarboxylase to treat calcium oxalate stones and promoting Lactobacillus in the intestinal flora . More interesting is that Human Embryonic Kidney 293 (HEK293) cells expressing OXDC are capable of degrading oxalate protect cells from oxidative damage and serve as a therapeutic option for prevention of CaOx stone disease …”

Navigating the Evolving Landscape of Primary Hyperoxaluria: Traditional Management Defied by the Rise of Novel Molecular Drugs

“…Based on this evidence, Agnieszka et al applied Lac therapy in two PH1 patients with distinct conditions (patient 1 in the anuric ESRD stage with systemic oxalosis and patient 2 with normal renal function), achieving a decrease in POx to below the target value, indicating Lac's potential therapeutic value for PH patients [72]. Wu et al's 2023 study demonstrated that zinc gluconate could markedly augment the abundance of oxalate-metabolizing bacteria in humans, thereby alleviating symptoms in a CaOx kidney stone rat model [73]. The relevant studies in this domain have provided novel insights and directions for future therapeutic research on PHs.…”