2004
DOI: 10.1074/jbc.m310799200
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Zn2+-stimulated Endocytosis of the mZIP4 Zinc Transporter Regulates Its Location at the Plasma Membrane

Abstract: Zinc is an essential nutrient for all organisms. Its requirement in humans is illustrated dramatically by the genetic disorder acrodermatitis enteropathica (AE). AE is caused by the reduced uptake of dietary zinc by enterocytes, and the ensuing systemic zinc deficiency leads to dermatological lesions and immune and reproductive dysfunction. The gene responsible for AE, SLC39A4, encodes a member of the ZIP family of metal transporters, hZIP4. The mouse ZIP4 protein, mZIP4, stimulates zinc uptake in cultured cel… Show more

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Cited by 142 publications
(148 citation statements)
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“…As was found previously for mZip4 (23), increased surface levels of mZip1-HA and mZip3-HA under zinc deficiency could be the result of decreased rates of endocytosis. To test this hypothesis, we examined antibody internalization in zinc-replete and deficient cells as described in Fig.…”
Section: Mzip1-ha and Mzip3-ha Distribution Is Altered By Zinc Statussupporting
confidence: 54%
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“…As was found previously for mZip4 (23), increased surface levels of mZip1-HA and mZip3-HA under zinc deficiency could be the result of decreased rates of endocytosis. To test this hypothesis, we examined antibody internalization in zinc-replete and deficient cells as described in Fig.…”
Section: Mzip1-ha and Mzip3-ha Distribution Is Altered By Zinc Statussupporting
confidence: 54%
“…Cells were transferred to ice to prevent further endocytosis, washed three times with ice-cold PBS, and surface-bound antibodies were removed by five washes with ice-cold acidic buffer (100 mM glycine, 20 mM magnesium acetate, 50 mM potassium chloride, pH 2.2). This treatment is sufficient to remove all detectable surface-bound antibodies (16,23). After two additional washes with ice-cold PBS, the cells were collected, lysed, and analyzed for anti-HA antibodies by immunoblotting as described above.…”
Section: Methodsmentioning
confidence: 99%
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