ZnO/Ag nanorods as a prominent SERS substrate contributed by synergistic charge transfer effect for simultaneous detection of oral antidiabetic drugs pioglitazone and phenformin

Liu, Chunyan; Xu, Xiaohui; Wang, Changding; Qiu, Guoyu; Ye, Weichun; Li, Yumin; Wang, Degui

doi:10.1016/j.snb.2019.127634

Cited by 75 publications

(38 citation statements)

References 45 publications

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“…Due to its promptness, high sensitivity and molecular specificity, SERS is particularly useful for drug detection. In recent years, the technique has been applied for the detection and quantification of antibiotics [9,14] and other pharmaceutical drugs [15,16] and also for screening illicit drugs [17,18]. SERS can also provide real-time in vivo monitoring of therapeutic drugs [19,20].…”

Section: Introductionmentioning

confidence: 99%

Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

et al. 2020

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Surface-enhanced Raman scattering (SERS) is a widely used technique for drug detection due to high sensitivity and molecular specificity. The applicability and selectivity of SERS in the detection of specific drug molecules can be improved by gathering information on the specific interactions occurring between the molecule and the metal surface. In this work, multilayer gold-silver bimetallic nanorods (Au@Ag@AuNRs) have been prepared and used as platforms for SERS detection of specific drugs (namely promethazine, piroxicam, furosemide and diclofenac). The analysis of SERS spectra provided accurate information on the molecular location upon binding and gave some insight into molecule-surface interactions and selectivity in drug detection through SERS.

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Section: Introductionmentioning

confidence: 99%

Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

et al. 2020

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“…As the photoreduction time increases to 40 min and 50 min, the SERS peak intensity of CPZ drops owing to the following causes: (1) the large deposition amount of Au NPs on the TiC surface leads to high particle aggregation, which hinders the interaction of CPZ molecules with the TiC; (2) the bigger Au NPs on the TiC surface relatively reduce the synergistic effect of TiC and Au NPs, as evidenced from the FESEM image in Fig. 2E [30]. The above experimental results clearly confirm that only an appropriate amount of Au NPs on the TiC surface can produce the maximum SERS enhancement effect.…”

Section: Sers Performance Of Different Tic/au-nps Sers Substratesmentioning

confidence: 99%

A photochemical approach to anchor Au NPs on MXene as a prominent SERS substrate for ultrasensitive detection of chlorpromazine

2021

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As a novel two-dimensional (2D) material, metal carbide (MXene) has been identified as a hotspot research topic in the field of surface-enhanced Raman spectroscopy (SERS). Herein, we report the increment of SERS activity of titanium carbide (TiC) by incorporation of gold nanoparticles (Au NPs) by a facile photoreduction process for the detection of antipsychotic drug. TiC anchored with Au NPs produce a remarkable SERS enhancement by the synergistic action of chemical and electromagnetic mechanisms. The hotspots are formed in the nanometer-scale gaps between Au NPs on the TiC surface for the effective interaction with probe molecules. The proposed TiC/Au-NPs SERS substrate was employed for the detection of chlorpromazine (CPZ) with the wide linear range of 10 −1 -10 −10 M and the ultra-low limit of detection of 3.92 × 10 −11 M. Besides, the SERS effect of the optimized TiC/Au-NPs for the 532 nm excitation exhibits the enhancement factor in the order of 10 9 with the relative standard deviation of < 13% for the uniformity and < 8.80% for the reproducibility. To ensure the practical feasibility of the proposed TiC/Au-NPs SERS substrate, the spike and recovery method was used for the detection of CPZ in human biological fluids like urine and saliva. This work can open up a new approach to improve the SERS activity of MXene-based SERS substrate for practical applications, especially the determination of antipsychotic drugs in environmental pollution management.

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“…Besides, graphene only absorbed 2.3% of light energy and minimized the loss of SERS signals from novel metal. In addition to graphene, one of the popular methods of improving the stability of substrate is to modify novel metal with semiconductor materials, such as TiO 2 [139], Al 2 O 3 [140], ZnO [141], SiO 2 [142], Cu 2 O [143], and ZrO 2 [144]. This method not only can keep nanoparticles from agglomeration, but also avoid the analyte or other interference directly contacting or polluting noble metal.…”

Section: How To Choose Suitable Substrate For Sers Detection Of Pesticidesmentioning

confidence: 99%

Rapid field trace detection of pesticide residue in food based on surface-enhanced Raman spectroscopy

Liang

Wen-wen

et al. 2021

Microchim Acta

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Surface-enhanced Raman spectroscopy is an alternative detection tool for monitoring food security. However, there is still a lack of a conclusion of SERS detection with respect to pesticides and real sample analysis, and the summary of intelligent algorithms in SERS is also a blank. In this review, a comprehensive report of pesticides detection using SERS technology is given. The SERS detection characteristics of different types of pesticides and the influence of substrate on inspection are discussed and compared by the typical ways of classification. The key points, including the progress in real sample analysis and Raman data processing methods with intelligent algorithm, are highlighted. Lastly, major challenges and future research trends of SERS analysis of pesticide residue are also addressed. SERS has been proven to be a powerful technique for rapid test of residue pesticides in complex food matrices, but there still is a tremendous development space for future research.

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ZnO/Ag nanorods as a prominent SERS substrate contributed by synergistic charge transfer effect for simultaneous detection of oral antidiabetic drugs pioglitazone and phenformin

Cited by 75 publications

References 45 publications

Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

A photochemical approach to anchor Au NPs on MXene as a prominent SERS substrate for ultrasensitive detection of chlorpromazine

Rapid field trace detection of pesticide residue in food based on surface-enhanced Raman spectroscopy

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