ZnO/CNT@Fe
            <sub>3</sub>
            O
            <sub>4</sub>
            induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Yousefi, Amir‐Mohammad; Safaroghli‐Azar, Ava; Fakhroueian, Zahra; Bashash, Davood

doi:10.1080/21691401.2020.1748885

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…Our recent study also reported that ZnO/RGO NCs show greater anticancer efficacy against cancer cells . The anticancer activity of ZnO-based NCs was found to be mediated through oxidative stress and apoptosis pathways. − …”

Section: Introductionmentioning

confidence: 87%

Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis

et al. 2022

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ZnO nanoparticles (NPs) have attracted great attention in cancer therapy because of their novel and tailorable physicochemical features. Pure ZnO NPs, molybdenum (Mo)-doped ZnO NPs, and Mo-ZnO/reduced graphene oxide nanocomposites (Mo-ZnO/RGO NCs) were prepared using a facile, inexpensive, and eco-friendly approach using date palm ( Phoenix dactylifera L.) fruit extract. Anticancer efficacy of green synthesized NPs/NCs was examined in two different cancer cells. The potential mechanism of the anticancer activity of green synthesized NPs/NCs was explored through oxidative stress and apoptosis. The syntheses of pure ZnO NPs, Mo-ZnO NPs, and Mo-ZnO/RGO NCs were confirmed by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and photoluminescence (PL). Dynamic light scattering (DLS) study indicated the excellent colloidal stability of green prepared samples. Mo-ZnO/RGO NCs exhibited threefold higher anticancer activity in human colon (HCT116) and breast (MCF7) cancer cells as compared to pure ZnO NPs. The anticancer activity of Mo-ZnO/RGO NCs was mediated through reactive oxygen species, p53, and the caspase-3 pathway. Moreover, cytocompatibility of Mo-ZnO/RGO NCs in human normal colon epithelial (NCM460) and normal breast epithelial cells (MCF10A) was much better than those of pure ZnO NPs. Altogether, green stabilized Mo-ZnO/RGO NCs exhibited enhanced anticancer performance and improved cytocompatibility because of green mediated good synergism between ZnO, Mo, and RGO. This study suggested the high nutritional value fruit-based facile preparation of ZnO-based nanocomposites for cancer therapy.

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Section: Introductionmentioning

confidence: 87%

Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis

et al. 2022

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“…Mesoporous silica nanoparticles (MSNs), featured with biochemical similarity with cell membranes, can both achieve anticancer and anti-angiogenesis purposes based on ROS [ 122 ]. Likewise, ZnO/CNT@FeO [ 123 ] and SASP/ZnO nanoparticles [ 124 ] can also increase ROS levels and facilitate cancer cell death. Though these studies are less reported about the detailed mechanisms, we hypothesis they must be closely related to the ROS-ncRNAs axis from above description.…”

Section: Therapeutic Implications Based On the Ros-ncrnas Axis In Cancermentioning

confidence: 99%

The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role

Zuo

Zhang

et al. 2022

Mol Cancer

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Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven by ROS require an aberrant redox homeostasis, that activates onco-signaling and avoids ROS-induced programmed death by orchestrating antioxidant systems. These processes are revealed to closely associate with noncoding RNAs (ncRNAs). On the basis of the available evidence, ncRNAs have been widely identified as multifarious modulators with the involvement of several key redox sensing pathways, such as NF-κB and Nrf2 signaling, therefore potentially becoming effective targets for cancer therapy. Furthermore, the vast majority of ncRNAs with property of easy detected in fluid samples (e.g., blood and urine) facilitate clinicians to monitor redox homeostasis, indicating a novel method for cancer diagnosis. Herein, focusing on carcinoma initiation, metastasis and chemoradiotherapy resistance, we aimed to discuss the ncRNAs-ROS network involved in cancer progression, and the potential clinical application as biomarkers and therapeutic targets.

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“…Based on unique properties such as minimal side effects and high specificity, magnetic iron oxide (Fe 3 O 4 ) NPs and ZnO NPs are assumed as the most attractive metal NPs and have attracted particular interest in scientific and medical communities [35,36]. Given the challenges with TKI treatment in CML patients [25], and based on significant antileukemic effects of a single agent of ZnO/CNT@Fe 3 O 4 nanocomposite against BCR/ABL-harboring CMLderived K562 cells [37], we investigated both the probable effect of this agent on Imatinib cytotoxicity and its underlying molecular mechanisms in CML cells. The results of the present study showed that simultaneous treatment with Imatinib and our synthesized ZnO/CNT@Fe 3 O 4 nanocomposite, which its successful formation was confirmed using TEM, Zeta potential measurement, DLS analysis, FTIR analysis, UV spectroscopy, and XRD, was indeed more effective in the reduction of both viability and metabolic activity in K562 cells as compared with Imatinib alone.…”

Section: Discussionmentioning

confidence: 99%

Application of ZnO/CNT@Fe₃O₄ nanocomposite in amplifying the anti-leukemic effects of Imatinib: a novel strategy to adjuvant therapy in chronic myeloid leukemia

Yousefi

Safaroghli‐Azar

Pourbagheri‐Sigaroodi

et al. 2021

Biomed. Mater.

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The advent of tyrosine kinase inhibitors in the therapeutic protocols of chronic myeloid leukemia (CML) was a revolution in the treatment strategies that guaranteed the achievement of complete remission for patients. However, due to different mutations bypassing the efficacy of Imatinib, novel and more effective treatments are indeed required for the treatment of CML. Our study declared that the combination of synthesized ZnO/CNT@Fe3O4 nanocomposite with Imatinib decreased survival of CML-derived K562 cells, probably through inducing reactive oxygen species-mediated apoptosis. We also found improved cytotoxicity in the presence of a well known autophagy inhibitor, indicating that the apoptotic effect of this treatment is enhanced via autophagy suppression. Investigating the molecular mechanisms for the growth-suppressive effect of ZnO/CNT@Fe3O4-plus-Imatinib suggested that up-regulation of SIRT1 ceased cell cycle progression by increasing the expression of p21 and p27 cyclin-dependent kinase inhibitors. Notably, we reported here for the first time that either direct or indirect suppression of c-Myc results in enhanced anti-leukemic efficacy, suggesting that overexpression of c-Myc plays a contributory role in attenuating the efficacy of ZnO/CNT@Fe3O4—Imatinib in K562 cells. Given the promising effect of ZnO/CNT@Fe3O4 in potentiating the anti-cancer effects of Imatinib in K562 cells, our study suggested that nanocomposite could be used as a tool for combined-strategy treatment. However, further in vivo experiments are needed to provide clues for the safety and efficacy of this nanocomposite.

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ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Abstract: Bashash (2020) ZnO/CNT@Fe 3 O 4 induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment, Artificial Cells,

Cited by 13 publications

References 34 publications

Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis

Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis

The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role

Application of ZnO/CNT@Fe₃O₄ nanocomposite in amplifying the anti-leukemic effects of Imatinib: a novel strategy to adjuvant therapy in chronic myeloid leukemia

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ZnO/CNT@Fe 3 O 4 induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Abstract: Bashash (2020) ZnO/CNT@Fe 3 O 4 induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment, Artificial Cells,

Cited by 13 publications

References 34 publications

Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis

Enhanced Anticancer Performance of Eco-Friendly-Prepared Mo-ZnO/RGO Nanocomposites: Role of Oxidative Stress and Apoptosis

The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role

Application of ZnO/CNT@Fe3O4 nanocomposite in amplifying the anti-leukemic effects of Imatinib: a novel strategy to adjuvant therapy in chronic myeloid leukemia

Contact Info

Product

Resources

About

ZnO/CNT@Fe ₃ O ₄ induces ROS-mediated apoptosis in chronic myeloid leukemia (CML) cells: an emerging prospective for nanoparticles in leukemia treatment

Application of ZnO/CNT@Fe₃O₄ nanocomposite in amplifying the anti-leukemic effects of Imatinib: a novel strategy to adjuvant therapy in chronic myeloid leukemia