ZnO/Cu2O heterojunction integrated fiber-optic biosensor for remote detection of cysteine

Wen, Xingyue; Chang, Xinyu; Li, Aohua; Yang, Xinghua; Tian, Fang; Liu, Zhihai; Copner, Nigel; Teng, Pingping; Yuan, Libo

doi:10.1016/j.bios.2022.115021

Cited by 14 publications

(3 citation statements)

References 31 publications

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“…Fiber-optic biosensor structures mainly have light sources, optical fibers, bio sensitive elements and signal detection systems; among these, the biosensitive elements are the key components of the sensors, and the commonly-used biosensitive elements mainly include antigens, antibodies, enzymes and nucleic acids [108]. The biochemical information generated modulates the physical characteristics of the transmitted light in the fiber, such as light intensity, light amplitude, phase, and so on, by selectively interacting with specific biosensitive elements (i.e., specific binding to antigen or receptor ligand; complementary base pairing of nucleic acid molecules; specificity of enzyme action to substrate).…”

Section: Fiber-based Biosensorsmentioning

confidence: 99%

Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas

Wang

Zhang

et al. 2023

Molecules

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Gliomas are the most common primary central nervous system tumors, with a high mortality rate. Early and accurate diagnosis of gliomas is critical for successful treatment. Biosensors are significant in the detection of molecular biomarkers because they are simple to use, portable, and capable of real-time analysis. This review discusses several important molecular biomarkers as well as various biosensors designed for glioma diagnosis, such as electrochemical biosensors and optical biosensors. We present our perspectives on the existing challenges and hope that this review can promote the improvement of biosensors.

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Section: Fiber-based Biosensorsmentioning

confidence: 99%

Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas

Wang

Zhang

et al. 2023

Molecules

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“…However, in the reported OF-PEC biosensors, the conductive and photocatalytic layers on the treated OF surface are often prepared by using methods like magnetron sputtering or chemical bath deposition. However, these techniques can be associated with drawbacks such as the requirement for expensive instruments, complex operations, and time-consuming processes. − This limits the scalability and practicality of OF-PEC biosensors, particularly in terms of their cost and manufacturing efficiency. Therefore, there is a need for alternative approaches that can simplify the fabrication process and make it more accessible for widespread use.…”

Section: Introductionmentioning

confidence: 99%

SILAR Growth of ZnO NSs/CdS QDs on the Optical Fiber-Based Opto-Electrode with Guided In Situ Light and Its Application for the “Signal-On” Detection of Inflammatory Cytokine

Zou,

Wu,

Zhou

et al. 2024

Anal. Chem.

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In this study, a novel integrated photoelectrochemical (PEC) sensor platform was proposed, utilizing an optical fiber (OF) as the working electrode for guided in situ light. A CdS quantum dots (QDs)/ZnO nanosheets (NSs) n-n heterojunction was quickly and easily constructed on the OF surface by successive ionic layer adsorption and reaction (SILAR). Au nanoparticles (NPs)@dsDNA as a capturing probe were modified on the CdS QDs/ZnO NSs@OF (CZ@OF). Due to the energy transfer between Au NPs@dsDNA and CdS QDs, the resultant optoelectrode has a lower background near zero, enabling the "signalon" detection of biomarkers (interleukin-6 (IL-6) as a model). The OF-PEC biosensor demonstrated a wide linear range from 1 to 100 pg mL −1 with a regression coefficient (R 2 ) of 0.9958 and an impressive detection limit (LOD) of 0.19 pg mL −1 . More significantly, the proposed OF-PEC can be successfully used for the detection of IL-6 in serum samples from patients with pulmonary arterial hypertension, and it showed consistency and is more sensitive to trace concentrations compared to BD FACSCanto II flow cytometry used at the hospital. This holds significance for an early disease diagnosis. Therefore, the proposed OF-PEC not only achieves integration of the light source and sensing interface but also enables sensitive and accurate "signal-on" detection of IL-6. Furthermore, due to the flexibility and remote detection capabilities of OF, the application of OF-PEC is expected to be expanded more widely. This approach opens up possibilities for advances in PEC sensing.

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“…In addition, Cu 2 O is utilized as a signal antibody tag to burst the signal. p-type Cu 2 O with a suitable bandgap of ∼1.9 eV has a high absorption coefficient in the visible region, , which can compete with the substrate material, and its formation of spatial bit resistance can further suppress the signal, thus improving the sensitivity of the sensor. Finally, Carcinogen antigen 15–3 (CA15–3) was used as a model for the construction of the photoelectrochemical sensor, and the test results showed that the sensor has good performance.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Perylene Diimide (PDI) Nanowire Sensitized In₂O₃@MgIn₂S₄ S-Scheme Heterojunction as Photoelectrochemical Biosensing Platform for the Detection of CA15–3

Hao,

Zhu,

Dong

et al. 2024

Anal. Chem.

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Inorganic/organic heterojunctions show promising applications as high-performance sensing platforms for photoelectrochemical (PEC) immunosensors. This work reports constructing a PEC biosensor for CA15−3 based on a self-assembled perylene diimide (PDI) nanowire sensitized In 2 O 3 @MgIn 2 S 4 S-scheme heterojunction platform. P-type semiconductor Cu 2 O nanoparticles were designed as a signal burst source and were used as immunoassay labels. The carboxyl group on selfassembled PDI nanowires eliminates the step of additional surface functionalization for covalent immobilization of the capture elements. The π−π stacking of PDI enhances electron generation efficiency, while the carboxylic acid groups on PDI promote electron transfer. The performance of the constructed sensor was validated using CA15−3 as a model. The experimental results showed that the sensor based on In 2 O 3 @MgIn 2 S 4 /PDI has excellent selectivity, stability, and reproducibility, and can sensitively detect CA15−3 in the range of 0.001−100 U•mL −1 with the detection limit of 0.00056 U•mL −1 . The sensor has a broad application prospect. It is hoped that this research work based on the unique advantages of the organic compound PDI will inspire other researchers to design light-responsive materials and promote the development of the field of photoelectrochemical sensing.

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ZnO/Cu2O heterojunction integrated fiber-optic biosensor for remote detection of cysteine

Cited by 14 publications

References 31 publications

Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas

Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas

SILAR Growth of ZnO NSs/CdS QDs on the Optical Fiber-Based Opto-Electrode with Guided In Situ Light and Its Application for the “Signal-On” Detection of Inflammatory Cytokine

Self-Assembled Perylene Diimide (PDI) Nanowire Sensitized In₂O₃@MgIn₂S₄ S-Scheme Heterojunction as Photoelectrochemical Biosensing Platform for the Detection of CA15–3

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ZnO/Cu2O heterojunction integrated fiber-optic biosensor for remote detection of cysteine

Cited by 14 publications

References 31 publications

Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas

Molecular Biomarkers and Recent Liquid Biopsy Testing Progress: A Review of the Application of Biosensors for the Diagnosis of Gliomas

SILAR Growth of ZnO NSs/CdS QDs on the Optical Fiber-Based Opto-Electrode with Guided In Situ Light and Its Application for the “Signal-On” Detection of Inflammatory Cytokine

Self-Assembled Perylene Diimide (PDI) Nanowire Sensitized In2O3@MgIn2S4 S-Scheme Heterojunction as Photoelectrochemical Biosensing Platform for the Detection of CA15–3

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Self-Assembled Perylene Diimide (PDI) Nanowire Sensitized In₂O₃@MgIn₂S₄ S-Scheme Heterojunction as Photoelectrochemical Biosensing Platform for the Detection of CA15–3