ZnO microparticle‐loaded chitosan/poly(vinyl alcohol)/acacia gum nanosphere‐based nanocomposite thin film wound dressings for accelerated wound healing

Abstract

The present study deals with the development of novel ZnO microparticle‐loaded chitosan/poly(vinyl alcohol)/acacia gum nanosphere‐based nanocomposite thin films through electrospraying and evaluation of their potential use in wound healing applications for skin. ZnO microparticles were synthesized and used as bioactive agents. Morphology, size distribution, structure, and dispersion of the synthesized ZnO microparticles were analyzed by scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy (TEM). ZnO microparticles were incorporated into the ternary nanocomposite films by electrospraying technique. Thermogravimetric analyses reveal that incorporation of ZnO microparticles into the nanocomposite structure improves the thermal stability. Mechanical analyses show that tensile strength reaches to the maximum value of 12.75 MPa with 0.6 wt % ZnO content. SEM and TEM micrographs demonstrate that the nanocomposite films consist of nanospheres with nanocapsular structures whose sizes are mostly between 250 and 550 nm. Viability tests established prevailing cellular performance of the fibroblasts on 0.6 wt % ZnO microparticle‐loaded nanocomposite films with a viability percentage of 160% compared to the control group. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48445.

Electrospun polylactic acid/sulfadiazine sodium/proteinase nanofibers and their applications in treating frostbite

“…Some articles have also proved that electrospun polylactic acid material also has a certain antibacterial effect. 47,48 There are few reports on the preparation of nano materials containing sulfadiazine sodium by electros pun fibers. In this study, the effects of different components of proteinase K/polylactic acid electros spun fibers containing sulfadiazine sodium on the release effect of drugs were evaluated, and the physical and angiogenic properties of sulfadiazine loaded nano fibers were characterized.…”

Improved mechanical, optical, and electrical properties of chitosan films with the synergistic reinforcing effect of carbon nanotubes and reduced graphene oxide for potential optoelectronic applications

“…Oriented rGO could improve TS and EB values in composite films. That could improve the dispersion and strong interaction of CSM and rGO, which lead to interfacial stress transfer for particleincorporated polymer composites and produces a stress concentration center [90,91].…”

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

“…For each substance, its intravenous targeting effect and controlled-release effects as well as its subcutaneous or intramuscular sustained-release, needs to be considered [161,165]. An example of the usage of nanospheres in wound dressing is ZnO-loaded chitosan/poly(vinyl alcohol)/acacia gum nanosphere-based nanocomposite thin films obtained through electrospraying [166]. Another interesting concept of dressing combining antimicrobial and regenerative properties was proposed by Müller et al The authors designed three-dimensional (3D) electrospun poly(D,L-lactide) (PLA) fibermats into which nanospheres, formed from amorphous calcium polyphosphate (polyP) nanoparticles (NP) and encapsulated retinol ('retinol/aCa-polyP-NS'nanospheres (NS)), had been incorporated [167].…”