ZnO nanoparticles-graphene oxide-reduced graphene oxide thin films assembled layer-by-layer through non-electrostatic interactions

Gross, Marcos A.; Mello, Alexandre; Paterno, Leonardo G.

doi:10.1088/2053-1591/ab320d

Cited by 4 publications

(6 citation statements)

References 46 publications

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“…Nanosheet-like structures of GOC and anchored ZnO nanoparticles were identified by TEM (Figure A,B) and SEM (Figure A,B). In particular, the SEM image of GOC-ZnO (Figure B) clearly shows that the ZnO nanoparticles exhibit an ellipsoidal shape, which is typically reached by ultrasound-assisted synthesis . The presence of ZnO anchored to GOC was confirmed further by EDS analysis (Figure S2).…”

Section: Resultsmentioning

confidence: 99%

“…ZnO nanoparticles were synthesized according to the method reported elsewhere . Briefly, an ethanolic solution of Zn(OAc) 2 ·2H 2 O (5 mmol; 1.10 g) was placed in a small borosilicate glass and submitted to horn sonication (135 W; duty cycle: 1 s on, 1 s off), while an ethanolic solution of LiOH·H 2 O (7 mmol; 0.29 g) was added dropwise.…”

Section: Methodsmentioning

confidence: 99%

“…Graphene oxide (GO) was produced by chemical oxidation and subsequent ultrasonic exfoliation of graphitic oxide, as reported elsewhere . Carboxylated graphene oxide (GOC) was obtained according to the method described by Zhang et al The entire process was carried out with a horn sonicator (Sonitech Branson, model Sonifier 450).…”

Section: Methodsmentioning

confidence: 99%

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Graphene Oxide/Zinc Oxide Nanocomposite Displaying Selective Toxicity to Glioblastoma Cell Lines

Jovito

Paterno

Sales

et al. 2021

ACS Appl. Bio Mater.

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Glioblastoma is considered the most aggressive and prevalent type of glioma. Resistance mechanisms, side effects, and the blood–brain barrier are factors that make its treatment difficult, requiring the development of alternative therapeutic strategies. Herein, we propose a nanocomposite composed of carboxylated graphene oxide nanosheets decorated with zinc oxide nanoparticles and post-functionalized with Pluronic (GOC-ZnO-P) for chemotherapy against U87MG and U138MG human glioblastoma cell lines. The GOC-ZnO-P formulation is fairly stable in the physiological medium (DMEM-FBS) and demonstrates selectivity toward tumor cell lines, even though it is less cytotoxic than free ZnO. Whereas the photothermal activity of the nanocomposite has a negligible cytotoxic effect, images obtained by scanning and transmission electron microscopies reveal that it induces changes in adhesion points and roughness of the tumor cell membrane, and it is uptaken through vesicles and capable of accumulating in the nucleus, a process that can induce cell death by apoptosis, as verified by flow cytometry. In summary, the GOC phase serves as an inert platform for transporting ZnO, which maintains its selectivity for tumor cells and does not interfere with the mechanisms for inducing apoptotic pathways. Therefore, the GOC-ZnO-P nanocomposite offers a strategy for glioblastoma treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Graphene Oxide/Zinc Oxide Nanocomposite Displaying Selective Toxicity to Glioblastoma Cell Lines

Jovito

Paterno

Sales

et al. 2021

ACS Appl. Bio Mater.

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“…GO aqueous dispersion samples were obtained after pulsed ultrasonic exfoliation (Branson 450, Ti tip, 150 W, 1 s/1 s on/off, 1 h) of graphitic oxide. Graphitic oxide was prepared using the Hummers method, and ethanolic ZnONP suspensions were prepared by the sol–gel method, as described by Gross and Mello . The concentrations, determined by gravimetry, of GO (water dispersion) and ZnONP (ethanol dispersion) suspensions used were 1.88 and 8.55 g L −1 , respectively.…”

Section: Methodsmentioning

confidence: 99%

“…GO/RGO nanocomposite films containing various metal oxide nanoparticles can display superior electrical properties and be used for an even larger variety of applications. The introduction of metal oxide nanoparticles, such as zinc oxide (ZnONPs), aluminum‐doped zinc oxide, and various mixed ferrites (MFe 2 O 4 , M = Co, Zn, Cu, Ni, Mn, and so on), into the GO/RGO matrix has been explored for manufacturing supercapacitors, pollutant sensors, lithium‐ion battery electrodes, and luminescent materials . This wide variety of devices is possible because GO/RGO has a high chemical affinity and numerous adsorption sites available to interact with metal oxide nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Laser Reduction of Graphene Oxide/Zinc Oxide Nanoparticle Nanocomposites as a One‐Step Process for Supercapacitor Fabrication

Júnior

Cardoso

Paterno

et al. 2020

Physica Status Solidi (a)

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Herein, the laser reduction of graphene oxide (GO) and zinc oxide nanoparticle (ZnONP) nanocomposite films is proposed as a one‐step process for supercapacitor fabrication. The films, deposited by casting onto a flexible poly(ethylene terephthalate) (PET) substrate coated with indium‐doped tin oxide (ITO), are subjected to laser irradiation (5 mW, 405 nm) to reduce the GO phase and produce laser‐reduced GO (LRGO). Scanning electron microscopy/energy dispersion spectroscopy (SEM–EDS), micro‐Raman spectroscopy, and current versus voltage (I × V) analyses show a partial reduction of GO to LRGO, forming several conductor‐insulating (LRGO/GO) microporous interfaces, and thereby favoring the formation of a supercapacitor structure. Moreover, the topmost LRGO film layer is extensively reduced, making it sufficiently conducting to work as the counter electrode as well. However, the reduction process is less effective when ZnONPs are introduced into the GO matrix because ZnONPs get clustered and scatter the incident laser before reaching the GO phase. The capacitive behavior, assessed by cyclic voltammetry and galvanostatic charge–discharge measurements, reveals the following specific capacitances: 2.68 F g−1 (GO/LRGO) and 1.44 F g−1 (GO/LRGO/ZnONP). The method proposed herein is advantageous because it produces the microcapacitor structures and LRGO counter electrode in a single laser reduction step.

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Sensing Materials: Functionalized Advanced Carbon-Based Nanomaterials

Barros¹,

Braunger²,

Oliveira³

et al. 2023

Encyclopedia of Sensors and Biosensors

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ZnO nanoparticles-graphene oxide-reduced graphene oxide thin films assembled layer-by-layer through non-electrostatic interactions

Cited by 4 publications

References 46 publications

Graphene Oxide/Zinc Oxide Nanocomposite Displaying Selective Toxicity to Glioblastoma Cell Lines

Graphene Oxide/Zinc Oxide Nanocomposite Displaying Selective Toxicity to Glioblastoma Cell Lines

Laser Reduction of Graphene Oxide/Zinc Oxide Nanoparticle Nanocomposites as a One‐Step Process for Supercapacitor Fabrication

Sensing Materials: Functionalized Advanced Carbon-Based Nanomaterials

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