ZnO nanopellets have selective anticancer activity

Krishna, Prashanth Gopala; Ananthaswamy, Prashanth Paduvarahalli; Yadavalli, Tejabhiram; Mutta, Nagabhushana Bhangi; Ananda, S.; Yogisha, S

doi:10.1016/j.msec.2016.02.039

Cited by 57 publications

(10 citation statements)

References 33 publications

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“…According to Saraswathi et al (2017) the region between 400 and 600 cm − 1 is attributed to Zn-O group. The similar results were presented by Krishna et al (2016). The authors have reported that the transmittance band at 445 cm − 1 corresponded to the Zn–O bonding and confirmed the presence of ZnO particles.…”

Section: Resultssupporting

confidence: 91%

“…Wang et al (2015) indicated that ZnO NPs have significant dose-dependent cytotoxic effect on human pulmonary adenocarcinoma cells LTEP-a-2. The study of Krishna et al (2016) demonstrated the high anticancer activity of ZnO nanoparticles against prostate and breast cancer cell lines. Krishna et al (2017) showed the anticancer activity of ZnO nanoparticles performed on two human cancer cell lines DU-145 (human prostate cell line) and Calu-6 (human pulmonary adenocarcinoma).…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

Dobrucka

Długaszewska

Kaczmarek

2017

Biomed Microdevices

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The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. The antimicrobial activity of ZnO nanoparticles synthesized using the Ch. majus extract was tested against standard strains of bacteria (Staphylococcus aureus NCTC 4163, Pseudomonas aeruginosa NCTC 6749, Escherichia coli ATCC 25922), yeast (Candida albicans ATCC 10231), filamentous fungi (molds: Aspergillus niger ATCC 16404, dermatophytes: Trichophyton rubrum ATCC 28188), clinical strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) and yeast (Candida albicans). The study showed that zinc oxide nanoparticles were excellent antimicrobial agents. What is more, biologically synthesized ZnO nanoparticles demonstrate high efficiency in treatment of human non-small cell lung cancer A549.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

Dobrucka

Długaszewska

Kaczmarek

2017

Biomed Microdevices

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“…ZnO nanoparticles manifested a promising cytotoxic effect against several cancer cell types; like PC-3, HCT116, A549 and MDA-MB-231 46. Despite the amazing anticancer activity of ZnO-NPs in different cancer cell types, there are very limited studies performed in vivo .…”

Section: Discussionmentioning

confidence: 99%

<p>Apoptosis and oxidative stress as relevant mechanisms of antitumor activity and genotoxicity of ZnO-NPs alone and in combination with N-acetyl cysteine in tumor-bearing mice</p>

El-Shorbagy

Eissa

Sabet

et al. 2019

IJN

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Background: Several in vitro studies have revealed that zinc oxide nanoparticles (ZnO-NPs) were able to target cancerous cells selectively with minimal damage to healthy cells. Purpose: In the current study, we aimed to evaluate the antitumor activity of ZnO-NPs in Ehrlich solid carcinoma (ESC) bearing mice by measuring their effect on the expression levels of P53, Bax and Bcl2 genes as indicators of apoptotic induction in tumor tissues. Also, we assessed the potential ameliorative or potentiation effect of 100 mg/kg N-acetyl cysteine (NAC) in combination with ZnO-NPs. Materials and methods: ESC bearing mice were gavaged with three different doses of ZnO-NPs (50, 300 and 500 mg/kg body weight) alone or in combination with NAC for seven consecutive days. In addition to measuring the tumor size, pathological changes, zinc content, oxidative stress biomarkers and DNA damage in ESC, normal muscle, liver and kidney tissues were assessed. Results: Data revealed a significant reduction in tumor size with a significant increase in p53 and Bax and decrease in Bcl2 expression levels in the tissues of ZnO-NPs treated ESC bearing mice. Moreover, a significant elevation of MDA accompanied with a significant reduction of CAT and GST. Also, a marked increase in all comet assay parameters was detected in ZnO-NPs treated groups. On the other hand, the combined treatment with ZnO-NPs and NAC significantly reduced reactive oxygen species production and DNA damage in liver and kidney tissues in all ZnO-NPs treated groups. Conclusion: ZnO-NPs exhibited a promising anticancer efficacy in ESC, this could serve as a foundation for developing new cancer therapeutics. Meanwhile, the combined treatment with ZnO-NPs and NAC could act as a protective method for the healthy normal tissue against ZnO-NPs toxicity, without affecting its antitumor activity.

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“…Zinc oxide, as a versatile nanomaterial, has been proved suitable for biotechnological applications by plenty of studies. − There are also several works dealing with enzyme immobilization on ZnO nanoparticles, , while these structures are on the list of the U.S. Food and Drug Administration (21CFRI82.8991) as safe (GRAS). β-Glucosidases (E.C 3.2.1.21) are well-characterized biological catalysts .…”

Section: Introductionmentioning

confidence: 99%

Development of a ZnO Nanowire Continuous Flow Microreactor with β-Glucosidase Activity: Characterization and Application for the Glycosylation of Natural Products

Gkantzou

Govatsi

Chatzikonstantinou

et al. 2021

ACS Sustainable Chem. Eng.

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Microreactor technology is being increasingly utilized in the field of biocatalysis, offering cost-effectiveness and environmental sustainability. On the other hand, enzyme immobilization on nanomaterials can provide biocatalytic systems with the operational stability demands of an intensified bioprocess. Combining the methodology for ZnO nanowire growth on glass surfaces with enzyme immobilization techniques, we developed a novel continuous-flow microbioreactor system, with β-glucosidase activity. Morphological, spectroscopic, and biocatalytic characterization of the developed enzyme microreactor is presented. The immobilized enzyme exhibited almost 100% remaining hydrolytic activity after 1000 cycles of continuous use and more than 70% residual activity after 24 h of exposure to different organic solvents. The system productivity was enhanced up to 10 times compared to the free enzyme form and 30 times compared to the batch immobilized system. Compared to previous studies in batch reactor systems, the enzyme microbioreactor exhibited a productivity enhancement of 315 and 12 times, respectively, for the continuous glycosylation of the natural compounds perillyl alcohol and tyrosol toward the synthesis of their bioactive glycosylated derivatives. The entire arrangement seems to provide a proper microenvironment for enzyme stabilization, under the scope to broaden the biocatalyst’s potentiality.

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ZnO nanopellets have selective anticancer activity

Cited by 57 publications

References 33 publications

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

<p>Apoptosis and oxidative stress as relevant mechanisms of antitumor activity and genotoxicity of ZnO-NPs alone and in combination with N-acetyl cysteine in tumor-bearing mice</p>

Development of a ZnO Nanowire Continuous Flow Microreactor with β-Glucosidase Activity: Characterization and Application for the Glycosylation of Natural Products

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