ZnO Nanorod FET Biosensors With Enhanced Sensing Performance: Design Issues for Rational Geometry Selection

Chakraborty, Bidesh; Mondal, Debasis; RoyChaudhuri, C.

doi:10.1109/jsen.2020.3005617

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…Sample has been heated at 70 °C to vaporize the remaining solvent. In the second stage, following earlier reported process, ZnO nanorods have been grown on the seeded area 39 . 50 mM Zn(NO 3 ) 2 ,6H 2 O has been added in 50 ml DI water and stirred for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Label free, electric field mediated ultrasensitive electrochemical point-of-care device for CEA detection

Chakraborty

Das

Mandal

et al. 2021

Sci Rep

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Developing point-of-care (PoC) diagnostic platforms for carcinoembryonic antigen detection is essential. However, thefew implementations of transferring the signal amplification strategies in electrochemical sensing on paper-based platforms are not satisfactory in terms of detection limit (LOD). In the quest for pushing down LOD, majority of the research has been targeted towards development of improved nanostructured substrates for entrapping more analyte molecules and augmenting the electron transfer rate to the working electrode. But, such approaches have reached saturation. This paper focuses on enhancing the mass transport of the analyte towards the sensor surface through the application of an electric field, in graphene-ZnO nanorods heterostructure. These hybrid nanostructures have been deposited on flexible polyethylene terephthalate substrates with screen printed electrodes for PoC application. The ZnO nanorods have been functionalized with aptamers and the working sensor has been integrated with smartphone interfaced indigenously developed low cost potentiostat. The performance of the system, requiring only 50 µl analyte has been evaluated using electrochemical impedance spectroscopy and validated against commercially available ELISA kit. Limit of detection of 1 fg/ml in human serum with 6.5% coefficient of variation has been demonstrated, which is more than three orders of magnitude lower than the existing attempts on PoC device.

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Section: Methodsmentioning

confidence: 99%

Label free, electric field mediated ultrasensitive electrochemical point-of-care device for CEA detection

Chakraborty

Das

Mandal

et al. 2021

Sci Rep

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“…It has low cost, is abundant, non-toxic, compatible with intercellular material, and possesses a large direct bandgap of 3.37 eV, contributing to high I ON /I OFF ratios [131]. In this way, ZnO NW (or nanorod (NR), as they are more commonly known) has gained a lot of attention as a semiconductor material for developing FET-based immunosensors [7,133]. One of the distinctions of ZnO NRs is their use to build FET in a non-planar configuration.…”

Section: Nanowires-silicon and Beyondmentioning

confidence: 99%

“…The main reason for that is the complexity of the operation principles and mechanisms of a biosensor. The first biosensor was introduced by the seminal work of Clark and Lyons in 1962 [2], and since then, a number of devices have been developed employing various materials for different applications [3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Addressing the Theoretical and Experimental Aspects of Low-Dimensional-Materials-Based FET Immunosensors: A Review

et al. 2021

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Electrochemical immunosensors (EI) have been widely investigated in the last several years. Among them, immunosensors based on low-dimensional materials (LDM) stand out, as they could provide a substantial gain in fabricating point-of-care devices, paving the way for fast, precise, and sensitive diagnosis of numerous severe illnesses. The high surface area available in LDMs makes it possible to immobilize a high density of bioreceptors, improving the sensitivity in biorecognition events between antibodies and antigens. If on the one hand, many works present promising results in using LDMs as a sensing material in EIs, on the other hand, very few of them discuss the fundamental interactions involved at the interfaces. Understanding the fundamental Chemistry and Physics of the interactions between the surface of LDMs and the bioreceptors, and how the operating conditions and biorecognition events affect those interactions, is vital when proposing new devices. Here, we present a review of recent works on EIs, focusing on devices that use LDMs (1D and 2D) as the sensing substrate. To do so, we highlight both experimental and theoretical aspects, bringing to light the fundamental aspects of the main interactions occurring at the interfaces and the operating mechanisms in which the detections are based.

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“…Second, BioFETs arrangements have multi-scale nature i.e., the biomolecules are on the angstrom scale while the device can reach to micrometer range. Moreover, FETs can also be designed as ZnO nanorods which have shown a remarkable performance in terms of stability 21 , that made it a great candidate to be used for the detection of Prostate Specific Antigen (PSA) 22 and Hepatitis B surface antigen 23 . Another interesting application using ZnO was reported by Chakraborty’s team, they employed the ZnO to create a thin film transistor (TFT) to detect Hepatitis B surface antigen the sensor was used to measure and enhance the reliability of bio-targets detection 24 .…”

Section: Introductionmentioning

confidence: 99%

The design of a point of care FET biosensor to detect and screen COVID-19

Wasfi

Awwad

2023

Sci Rep

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Graphene field effect transistor (FET) biosensors have attracted huge attention in the point-of-care and accurate detection. With the recent spread of the new emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the need for rapid, and accurate detection & screening tools is arising. Employing these easy-to-handle sensors can offer cheap, rapid, and accurate detection. Herein, we propose the design of a reduced graphene oxide (rGO) FET biosensor for the detection of SARS-CoV-2. The main objective of this work is to detect the SARS-CoV-2 spike protein antigen on spot selectively and rapidly. The sensor consists of rGO channel, a pair of golden electrodes, and a gate underneath the channel. The channel is functionalized with COVID-19 spike protein antibodies to achieve selectivity, and with metal nanoparticles (MNPs) such as copper and silver to enhance the bio-sensing performance. The designed sensor successfully detects the SARS-CoV-2 spike protein and shows singular electrical behavior for detection. The semi-empirical modeling approach combined with none-equilibrium Green’s function were used to study the electronic transport properties of the rGO-FET biosensor before and after the addition of the target molecules. The sensor’s selectivity is also tested against other viruses. This study provides a promising guide for future practical fabrication.

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ZnO Nanorod FET Biosensors With Enhanced Sensing Performance: Design Issues for Rational Geometry Selection

Cited by 7 publications

References 38 publications

Label free, electric field mediated ultrasensitive electrochemical point-of-care device for CEA detection

Label free, electric field mediated ultrasensitive electrochemical point-of-care device for CEA detection

Addressing the Theoretical and Experimental Aspects of Low-Dimensional-Materials-Based FET Immunosensors: A Review

The design of a point of care FET biosensor to detect and screen COVID-19

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