ZnO nanostructures: A promising frontier in immunosensor development

Brasiunas, Benediktas; Popov, Anton; Lisyte, Viktorija; Kausaite-Minkstimiene, Asta; Ramanaviciene, Almira

doi:10.1016/j.bios.2023.115848

Cited by 11 publications

(1 citation statement)

References 142 publications

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“…Additionally, ZnO nanostructures can be synthesized in large amounts using the hydrothermal method, which is a cost-effective and straightforward process [ 35 , 36 ]. Due to their high surface area-to-volume ratio, ZnO NRs are particularly advantageous for chemical/biological sensors, offering great promise as highly sensitive and stable sensors [ 35 , 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

An Electroanalytical Enzymeless α-Fe2O3-ZnO Hybrid Nanostructure-Based Sensor for Sensitive Quantification of Nitrite Ions

Ahmad,

Abdullah,

Rehman

et al. 2024

Nanomaterials

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Nitrite monitoring serves as a fundamental practice for protecting public health, preserving environmental quality, ensuring food safety, maintaining industrial safety standards, and optimizing agricultural practices. Although many nitrite sensing methods have been recently developed, the quantification of nitrite remains challenging due to sensitivity and selectivity limitations. In this context, we present the fabrication of enzymeless iron oxide nanoparticle-modified zinc oxide nanorod (α-Fe2O3-ZnO NR) hybrid nanostructure-based nitrite sensor fabrication. The α-Fe2O3-ZnO NR hybrid nanostructure was synthesized using a two-step hydrothermal method and characterized in detail utilizing x-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). These analyses confirm the successful synthesis of an α-Fe2O3-ZnO NR hybrid nanostructure, highlighting its morphology, purity, crystallinity, and elemental constituents. The α-Fe2O3-ZnO NR hybrid nanostructure was used to modify the SPCE (screen-printed carbon electrode) for enzymeless nitrite sensor fabrication. The voltammetric methods (i.e., cyclic voltammetry (CV) and differential pulse voltammetry (DPV)) were employed to explore the electrochemical characteristics of α-Fe2O3-ZnO NR/SPCE sensors for nitrite. Upon examination of the sensor’s electrochemical behavior across a range of nitrite concentrations (0 to 500 µM), it is evident that the α-Fe2O3-ZnO NR hybrid nanostructure shows an increased response with increasing nitrite concentration. The sensor demonstrates a linear response to nitrite concentrations up to 400 µM, a remarkable sensitivity of 18.10 µA µM−1 cm−2, and a notably low detection threshold of 0.16 µM. Furthermore, its exceptional selectivity, stability, and reproducibility make it an ideal tool for accurately measuring nitrite levels in serum, yielding reliable outcomes. This advancement heralds a significant step forward in the field of environmental monitoring, offering a potent solution for the precise assessment of nitrite pollution.

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Section: Introductionmentioning

confidence: 99%

An Electroanalytical Enzymeless α-Fe2O3-ZnO Hybrid Nanostructure-Based Sensor for Sensitive Quantification of Nitrite Ions

Ahmad,

Abdullah,

Rehman

et al. 2024

Nanomaterials

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Photoelectrochemical Immunoassay of Alpha‐Fetoprotein Based on Au Nanoparticles‐Decorated ZnO Microrods

Xu,

Wang,

Chen

et al. 2024

Electroanalysis

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Herein a split‐type photoelectrochemical (PEC) immunosensor based on in situ grown gold nanoparticles (Au NPs) on the surface of ZnO microrods (ZnO MRs) was devised for the detection of alpha‐fetoprotein (AFP) by employing dopamine (DA)‐loaded liposomes as the signal amplification strategy. Specifically, as the level of AFP rises, a proportional number of sandwich‐type immunocomplexes form in the well of the microplate, which can introduce a corresponding amount of DA‐encapsulated liposomes at the same time. Encapsulated DA molecules will be released with the stimulation of Triton X‐100, thereby resulting in the marked enhancement of the PEC signal. Under optimized conditions, the proposed PEC immunosensing platform displays specific photocurrent responses toward AFP in a broad dynamic working range of 0.05 −50 ng mL−1, achieving an impressively low limit of detection (LOD) of 18.7 pg mL−1. Furthermore, this methodology not only displays high specificity, and satisfactory storage stability but also ensures acceptable accuracy and practicality for the analytical applications of human serum samples.

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AIEgens-based luminescent metal-organic frameworks as novel electrochemiluminescence emitters Integrated with co-reaction amplification strategy for CA15-3 detection

Li,

Hao,

Zhang

et al. 2024

Chemical Engineering Journal

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ZnO nanostructures: A promising frontier in immunosensor development

Cited by 11 publications

References 142 publications

An Electroanalytical Enzymeless α-Fe2O3-ZnO Hybrid Nanostructure-Based Sensor for Sensitive Quantification of Nitrite Ions

An Electroanalytical Enzymeless α-Fe2O3-ZnO Hybrid Nanostructure-Based Sensor for Sensitive Quantification of Nitrite Ions

Photoelectrochemical Immunoassay of Alpha‐Fetoprotein Based on Au Nanoparticles‐Decorated ZnO Microrods

AIEgens-based luminescent metal-organic frameworks as novel electrochemiluminescence emitters Integrated with co-reaction amplification strategy for CA15-3 detection

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