In 2010, the fundamentals of piezo-phototronics were introduced. By applying stress, a piezo potential is formed in a non-central symmetrical crystal due to ion polarisation. Due to the co-existence of semiconductor and piezoelectricity characteristics, piezo potential induced in the crystal is of significant impact on charge transfer at the junction/interface. The phototronic product uses the piezo capability to manage carrier formation, separation, transportation, and recombination to improve the performance of optoelectronic devices such as photon detectors, solar cells and LED. Today, most of the unique applications in this field can be found in sensing, human-computer interfacing, actuating nanorobotics by effectively integrating piezo-phototronic devices and piezotronic with silicon-based CMOS technology. This chapter gives an insight into the fundamentals of piezo-phototronics.