ZnO:V Nanoparticles with Enhanced Antimicrobial Activities

Alaya, L.; Saeedi, Ahmad M.; Alsaigh, Ahmad A.; M, Almalki; Alonizan, N.; Hjiri, M.

doi:10.3390/jcs7050190

Cited by 8 publications

(2 citation statements)

References 48 publications

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“…However, excess production of ROS can also be observed due to the radiation and metabolism of drugs or xenobiotics [ 40 ], which is beyond the enzymes capacity to neutralize. A major effect of ROS is lipid peroxidation, which damages the phospholipid-rich bacterial cell membranes leading to cell leakage and death [ 42 , 43 ]. Bacterial cells incorporate linoleic acids and phospholipids in their membrane, which during lipid peroxidation, results in the formation of lipid hydroperoxide, which is further converted to aldehydes including MDA in the presence of oxidation products [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Biogenic Metal Oxide Nanoparticles and Their Synergistic Effect on Clinical Pathogens

Francis

Jayakumar

Gokhale

2023

IJMS

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The rising prevalence of antibiotic-resistance is currently a grave issue; hence, novel antimicrobial agents are being explored and developed to address infections resulting from multiple drug-resistant pathogens. Biogenic CuO, ZnO, and WO3 nanoparticles can be considered as such agents. Clinical isolates of E. coli, S. aureus, methicillin-resistant S. aureus (MRSA), and Candida albicans from oral and vaginal samples were treated with single and combination metal nanoparticles incubated under dark and light conditions to understand the synergistic effect of the nanoparticles and their photocatalytic antimicrobial activity. Biogenic CuO and ZnO nanoparticles exhibited significant antimicrobial effects under dark incubation which did not alter on photoactivation. However, photoactivated WO3 nanoparticles significantly reduced the number of viable cells by 75% for all the test organisms, thus proving to be a promising antimicrobial agent. Combinations of CuO, ZnO, and WO3 nanoparticles demonstrated synergistic action as a significant increase in their antimicrobial property (>90%) was observed compared to the action of single elemental nanoparticles. The mechanism of the antimicrobial action of metal nanoparticles both in combination and in isolation was assessed with respect to lipid peroxidation due to ROS (reactive oxygen species) generation by measuring malondialdehyde (MDA) production, and the damage to cell integrity using live/dead staining and quantitating with the use of flow cytometry and fluorescence microscopy.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Biogenic Metal Oxide Nanoparticles and Their Synergistic Effect on Clinical Pathogens

Francis

Jayakumar

Gokhale

2023

IJMS

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“…Zinc oxide is an n-type semiconductor with high binding energy [38]. ZnO nanoparticles can interact with water to form ROS [39]. The ROS can destroy cell membranes, proteins, and DNA through oxidation and eventually cause bacterial inactivation.…”

Section: Biological Properties Of Modified Coatingsmentioning

confidence: 99%

Antibacterial Calcium Phosphate Coatings with Zinc Oxide Nanoparticles

Chebodaeva,

Sedelnikova,

Khimich

et al. 2023

Coatings

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Porous calcium phosphate coatings (C-P) with ZnO nanoparticles were obtained via the micro-arc oxidation method on a titanium substrate. ZnO nanoparticles were added to the C-P coatings to change the zeta potential and improve the coatings’ bioactivity and antibacterial properties. The samples with coatings were studied via scanning electron microscopy (SEM), X-ray diffraction, energy dispersive microanalysis, potentiodynamic polarization, and zeta potential measurement. The coatings modified with ZnO nanoparticles showed improved physical, electrochemical, and electrical properties, compared to the initial unmodified coatings. Modification with ZnO nanoparticles contributed to an increase in zeta potential from −60 mV to −53 mV. Functionalization of the coatings with ZnO nanoparticles allowed us to increase the anticorrosion characteristics by about 30%. The biological studies showed that the coatings had no cytotoxic effect on L929 fibroblast cells. The antibacterial activity of the coating rose by 99% after the addition of ZnO nanoparticles against the bacterium Staphylococcus aureus.

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Analyzing antimicrobial activity of ZnO/FTO, Sn–Cu‐doped ZnO/FTO thin films: Production and characterizations

Kara,

Hafedh,

Alhusseinawi

et al. 2024

Microscopy Res & Technique

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In the developing field of nanotechnology, ZnO (zinc oxide) based semiconductor samples have emerged as the foremost choice due to their immense potential for advancing the development of cutting‐edge nanodevices. Due to its excellent chemical stability, low cost, and non‐toxicity to biological systems, it is also utilized in various investigations. In this study, the successive ionic layer adsorption and reaction (SILAR) method was used to generate FTO (fluorine‐doped tin oxide)/ZnO, and tin (Sn)–copper (Cu)‐doped ZnO thin films at varying concentrations on FTO substrates. After being stacked 40 times in varying concentrations on the FTO substrate, FTO/ZnO thin films and Sn–Cu‐doped thin films were annealed at 300°C. Using Scanning Electron Microscopy (SEM) Energy Dispersive Spectroscopy‐(EDS), the agar diffusion test, and the viability cell counting method, the minimum inhibitory concentration, structural properties, surface morphology, antibacterial properties, bacterial adhesion, and survival organism count of FTO/ZnO thin films and Sn–Cu‐doped thin films were investigated. Both doped and FTO/ZnO films with varying Sn–Cu concentrations expanded harmonically on the FTO substrate, according to the SEM‐EDS investigation. The doping concentration affected their morphological properties, causing changes depending on the doping level. Antibacterial activity was observed in the powder metals, but no antibacterial activity was found in the thin film form. The highest adhesion rate of bacterial organisms on the produced samples was observed when the FTO/ZnO/Sn–Cu doping rate was 1%. In addition, the lowest adhesion rate was observed when the FTO/ZnO/Sn–Cu additive ratio was 3%.Research Highlights ZnO based semiconductors highlight significant potential in advancing nanodevice technology due to their chemical stability, cost‐effectiveness, and biocompatibility. Employing the SILAR method, the study innovatively fabricates FTO/ZnO and Sn–Cu‐doped ZnO thin films on FTO substrates, exploring a novel approach in semiconductor manufacturing. Post annealing at 300°C, the research examines the structural and surface morphological changes in the films, contributing to the understanding of semiconductor behavior under varying conditions. The study delves into the antibacterial properties of ZnO thin films, offering insights into the potential biomedical applications of these materials. SEM‐EDS analysis reveals that doping concentrations crucially influence the morphological properties of ZnO thin films, shedding light on the optimization of semiconductor performance. Findings indicate a specific doping rate (1% Sn–Cu) enhances bacterial adhesion, while a 3% additive ratio minimizes it, suggesting implications for biomedical device engineering and antibacterial surface design.

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ZnO:V Nanoparticles with Enhanced Antimicrobial Activities

Cited by 8 publications

References 48 publications

Antimicrobial Activity of Biogenic Metal Oxide Nanoparticles and Their Synergistic Effect on Clinical Pathogens

Antimicrobial Activity of Biogenic Metal Oxide Nanoparticles and Their Synergistic Effect on Clinical Pathogens

Antibacterial Calcium Phosphate Coatings with Zinc Oxide Nanoparticles

Analyzing antimicrobial activity of ZnO/FTO, Sn–Cu‐doped ZnO/FTO thin films: Production and characterizations

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